ID   OSTF1_PIG               Reviewed;         214 AA.
AC   Q8MJ49;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Osteoclast-stimulating factor 1;
GN   Name=OSTF1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RA   Guo J.H.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC       cascade which results in the secretion of factor(s) enhancing
CC       osteoclast formation and activity. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SRC and SMN1. Interacts with FASLG (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The SH3 domain mediates interaction with SMN1. {ECO:0000250}.
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DR   EMBL; AF523268; AAM82161.1; -; mRNA.
DR   RefSeq; NP_999170.1; NM_214005.1.
DR   AlphaFoldDB; Q8MJ49; -.
DR   SMR; Q8MJ49; -.
DR   STRING; 9823.ENSSSCP00000005664; -.
DR   PaxDb; Q8MJ49; -.
DR   PeptideAtlas; Q8MJ49; -.
DR   PRIDE; Q8MJ49; -.
DR   Ensembl; ENSSSCT00000042535; ENSSSCP00000040545; ENSSSCG00000005273.
DR   Ensembl; ENSSSCT00005046830; ENSSSCP00005028802; ENSSSCG00005029432.
DR   Ensembl; ENSSSCT00015045728; ENSSSCP00015018103; ENSSSCG00015033274.
DR   Ensembl; ENSSSCT00025045439; ENSSSCP00025019372; ENSSSCG00025033181.
DR   Ensembl; ENSSSCT00030066651; ENSSSCP00030030529; ENSSSCG00030047635.
DR   Ensembl; ENSSSCT00040049428; ENSSSCP00040020544; ENSSSCG00040036826.
DR   Ensembl; ENSSSCT00045048507; ENSSSCP00045033723; ENSSSCG00045028413.
DR   Ensembl; ENSSSCT00050105690; ENSSSCP00050046549; ENSSSCG00050076870.
DR   Ensembl; ENSSSCT00055049870; ENSSSCP00055039844; ENSSSCG00055025207.
DR   Ensembl; ENSSSCT00060021859; ENSSSCP00060009020; ENSSSCG00060016387.
DR   Ensembl; ENSSSCT00065103139; ENSSSCP00065045549; ENSSSCG00065074717.
DR   Ensembl; ENSSSCT00070057116; ENSSSCP00070048545; ENSSSCG00070028477.
DR   Ensembl; ENSSSCT00070057119; ENSSSCP00070048548; ENSSSCG00070028477.
DR   GeneID; 397066; -.
DR   KEGG; ssc:397066; -.
DR   CTD; 26578; -.
DR   VGNC; VGNC:91085; OSTF1.
DR   eggNOG; ENOG502QTZB; Eukaryota.
DR   GeneTree; ENSGT00920000149159; -.
DR   HOGENOM; CLU_092255_0_0_1; -.
DR   InParanoid; Q8MJ49; -.
DR   OMA; NMSWLRE; -.
DR   OrthoDB; 1453481at2759; -.
DR   TreeFam; TF314534; -.
DR   Reactome; R-SSC-6798695; Neutrophil degranulation.
DR   ChiTaRS; OSTF1; pig.
DR   Proteomes; UP000008227; Chromosome 1.
DR   Proteomes; UP000314985; Chromosome 1.
DR   Bgee; ENSSSCG00000005273; Expressed in spleen and 44 other tissues.
DR   ExpressionAtlas; Q8MJ49; baseline and differential.
DR   Genevisible; Q8MJ49; SS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ANK repeat; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Repeat; SH3 domain.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   CHAIN           2..214
FT                   /note="Osteoclast-stimulating factor 1"
FT                   /id="PRO_0000238955"
FT   DOMAIN          12..71
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REPEAT          72..101
FT                   /note="ANK 1"
FT   REPEAT          105..135
FT                   /note="ANK 2"
FT   REPEAT          139..168
FT                   /note="ANK 3"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   MOD_RES         200
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   MOD_RES         213
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
SQ   SEQUENCE   214 AA;  23740 MW;  EF9D43D511510D32 CRC64;
     MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW KGTSKGRTGL
     IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN GLDKAGSTAL YWACHGGHKD
     IVDMLFTQPN IELNQQNKLG DTALHAAAWK GYADIVQLLL AKGARTDLRN NEKKLALDMA
     TNAACASLLK KKQGTDAVRT LSNAEDYLDD EDSD