ID   OSTF1_XENLA             Reviewed;         214 AA.
AC   Q7ZYG4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Osteoclast-stimulating factor 1;
GN   Name=ostf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC       cascade which results in the secretion of factor(s) enhancing
CC       osteoclast formation and activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC043796; AAH43796.1; -; mRNA.
DR   RefSeq; NP_001080411.1; NM_001086942.1.
DR   AlphaFoldDB; Q7ZYG4; -.
DR   SMR; Q7ZYG4; -.
DR   DNASU; 380103; -.
DR   GeneID; 380103; -.
DR   KEGG; xla:380103; -.
DR   CTD; 380103; -.
DR   Xenbase; XB-GENE-1018483; ostf1.L.
DR   OMA; YVDENTE; -.
DR   OrthoDB; 1453481at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 380103; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat; SH3 domain.
FT   CHAIN           1..214
FT                   /note="Osteoclast-stimulating factor 1"
FT                   /id="PRO_0000238960"
FT   DOMAIN          12..71
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REPEAT          72..101
FT                   /note="ANK 1"
FT   REPEAT          105..135
FT                   /note="ANK 2"
FT   REPEAT          139..168
FT                   /note="ANK 3"
SQ   SEQUENCE   214 AA;  23705 MW;  BB4114D4480D9CDE CRC64;
     MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDILY IADMSDTNWW KGTCKGKTGL
     IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLENRVGVN GLDKAGSTAL YWGCHGGHKD
     VVDMLLAQPN IELNQQNKLG DTALHAAAWK GYADIVELLL VKGARTDLRN NEKKLALDMA
     TNAQCASLLK KKQAQGIVRT SSNADEYLDD EDSD