ID   OSTN_MACFA              Reviewed;         133 AA.
AC   G7NYP9;
DT   15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Osteocrin {ECO:0000250|UniProtKB:P61364};
DE   Contains:
DE     RecName: Full=Processed Osteocrin {ECO:0000250|UniProtKB:P61364};
DE   Flags: Precursor;
GN   Name=OSTN; ORFNames=EGM_11211 {ECO:0000312|EMBL:EHH51768.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000312|Proteomes:UP000009130};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [2]
RP   INDUCTION.
RX   PubMed=27830782; DOI=10.1038/nature20111;
RA   Ataman B., Boulting G.L., Harmin D.A., Yang M.G., Baker-Salisbury M.,
RA   Yap E.L., Malik A.N., Mei K., Rubin A.A., Spiegel I., Durresi E.,
RA   Sharma N., Hu L.S., Pletikos M., Griffith E.C., Partlow J.N., Stevens C.R.,
RA   Adli M., Chahrour M., Sestan N., Walsh C.A., Berezovskii V.K.,
RA   Livingstone M.S., Greenberg M.E.;
RT   "Evolution of Osteocrin as an activity-regulated factor in the primate
RT   brain.";
RL   Nature 539:242-247(2016).
CC   -!- FUNCTION: Hormone that acts as a regulator of dendritic growth in the
CC       developing cerebral cortex in response to sensory experience. Induced
CC       in the brain following membrane depolarization and inhibits dendritic
CC       branching in neurons of the developing cortex (By similarity). Probably
CC       acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby
CC       preventing binding between NPR3/NPR-C and natriuretic peptides, leading
CC       to increase cGMP production (By similarity).
CC       {ECO:0000250|UniProtKB:P61364, ECO:0000250|UniProtKB:P61366}.
CC   -!- SUBUNIT: Interacts with NPR3. {ECO:0000250|UniProtKB:P61364}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P61366}.
CC   -!- INDUCTION: Expression is induced by neuronal activity in the developing
CC       cerebral cortex: expression is driven by the presence of a enhancer
CC       sequence only present in primates that binds the MEF2 transcription
CC       factors (PubMed:27830782). {ECO:0000269|PubMed:27830782}.
CC   -!- SIMILARITY: Belongs to the Osteocrin family. {ECO:0000305}.
CC   -!- CAUTION: This protein-coding gene has been repurposed in primates, with
CC       the presence of a new enhancer sequence that drives expression in brain
CC       in response to sensory experience, leading to restrict dendritic growth
CC       in the developing cortex (PubMed:27830782).
CC       {ECO:0000269|PubMed:27830782}.
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DR   EMBL; CM001277; EHH51768.1; -; Genomic_DNA.
DR   RefSeq; XP_005545460.1; XM_005545403.2.
DR   AlphaFoldDB; G7NYP9; -.
DR   STRING; 9541.XP_005545460.1; -.
DR   Ensembl; ENSMFAT00000029154; ENSMFAP00000000980; ENSMFAG00000054957.
DR   GeneID; 102131583; -.
DR   KEGG; mcf:102131583; -.
DR   CTD; 344901; -.
DR   VEuPathDB; HostDB:ENSMFAG00000000060; -.
DR   eggNOG; ENOG502S2R3; Eukaryota.
DR   GeneTree; ENSGT00390000001750; -.
DR   OMA; AIFLMQW; -.
DR   OrthoDB; 1512795at2759; -.
DR   Proteomes; UP000009130; Chromosome 2.
DR   Proteomes; UP000233100; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0003416; P:endochondral bone growth; IEA:Ensembl.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1903860; P:negative regulation of dendrite extension; ISS:UniProtKB.
DR   GO; GO:0046325; P:negative regulation of glucose import; IEA:Ensembl.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR   InterPro; IPR021088; Osteocrin.
DR   PANTHER; PTHR35353; PTHR35353; 1.
DR   Pfam; PF11037; Musclin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Developmental protein;
KW   Differentiation; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..133
FT                   /note="Osteocrin"
FT                   /evidence="ECO:0000250|UniProtKB:P61364"
FT                   /id="PRO_0000439032"
FT   PEPTIDE         83..132
FT                   /note="Processed Osteocrin"
FT                   /evidence="ECO:0000250|UniProtKB:P61364"
FT                   /id="PRO_0000439033"
FT   MOD_RES         132
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  14749 MW;  391BD7BDB0C65E15 CRC64;
     MLDWRLASAH FILAVTLTLW NSGKVLSVDV TTTEAFDSGV IDVQSTPTVR EEKSATDLTA
     KLLLLDELVS LENDVIETKK KRSFSGFGSP LDRLSAGSVD HKGKQRKVVD HPKRRFGIPM
     DRIGRNRLSN SRG