ID   OSTR4_STRCA             Reviewed;          42 AA.
AC   P85116;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Ostricacin-4;
DE   AltName: Full=Beta-defensin 8;
DE   Flags: Fragment;
OS   Struthio camelus (Common ostrich).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Blood {ECO:0000269|PubMed:16459058};
RX   PubMed=16459058; DOI=10.1016/j.ijantimicag.2005.10.013;
RA   Sugiarto H., Yu P.-L.;
RT   "Identification of three novel ostricacins: an update on the phylogenetic
RT   perspective of beta-defensins.";
RL   Int. J. Antimicrob. Agents 27:229-235(2006).
CC   -!- FUNCTION: Has antibacterial activity against the Gram-positive
CC       bacterium S.aureus 1056 MRSA (MIC=11.48 ug/ml) and the Gram-negative
CC       bacterium E.coli O157:H7 (MIC=12.03 ug/ml). Does not have antifungal
CC       activity against the yeast C.albicans 3153A.
CC       {ECO:0000269|PubMed:16459058}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=4752.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16459058};
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000255}.
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DR   AlphaFoldDB; P85116; -.
DR   SMR; P85116; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   PEPTIDE         1..>42
FT                   /note="Ostricacin-4"
FT                   /evidence="ECO:0000269|PubMed:16459058"
FT                   /id="PRO_0000284753"
FT   DISULFID        8..36
FT                   /evidence="ECO:0000250|UniProtKB:P83430"
FT   DISULFID        15..30
FT                   /evidence="ECO:0000250|UniProtKB:P83430"
FT   DISULFID        20..37
FT                   /evidence="ECO:0000250|UniProtKB:P83430"
FT   NON_TER         42
FT                   /evidence="ECO:0000303|PubMed:16459058"
SQ   SEQUENCE   42 AA;  4755 MW;  C599A29D7D7C4667 CRC64;
     LPVNEAQCRQ VGGYCGLRIC NFPSRFLGLC TRNHPCCSRV WV