ID   OTCC_STRPY              Reviewed;         107 AA.
AC   P0C0C9; P16964;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Ornithine carbamoyltransferase, catabolic;
DE            Short=OTCase;
DE            EC=2.1.3.3;
DE   Flags: Fragment;
GN   Name=arcB;
OS   Streptococcus pyogenes.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 21060 / Su / DSM 2072;
RA   Kanaoka M., Kawanaka C., Negoro T., Fukita Y., Taya K., Agui H.;
RT   "Cloning and expression of the antitumor glycoprotein gene of Streptococcus
RT   pyogenes Su in Escherichia coli.";
RL   Agric. Biol. Chem. 51:2641-2648(1987).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline +
CC         phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743,
CC         ChEBI:CHEBI:58228; EC=2.1.3.3;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. OTCase family. {ECO:0000305}.
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DR   EMBL; D13790; BAA02940.1; -; Genomic_DNA.
DR   PIR; PE0009; PE0009.
DR   AlphaFoldDB; P0C0C9; -.
DR   SMR; P0C0C9; -.
DR   eggNOG; COG0078; Bacteria.
DR   UniPathway; UPA00254; UER00365.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.1370; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002292; Orn/put_carbamltrans.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00102; OTCASE.
DR   SUPFAM; SSF53671; SSF53671; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Transferase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..>107
FT                   /note="Ornithine carbamoyltransferase, catabolic"
FT                   /id="PRO_0000113037"
FT   BINDING         57..61
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /evidence="ECO:0000250"
FT   BINDING         84
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /evidence="ECO:0000250"
FT   SITE            32
FT                   /note="Important for structural integrity"
FT                   /evidence="ECO:0000250"
FT   NON_TER         107
SQ   SEQUENCE   107 AA;  12079 MW;  B6CC2FF49D77D330 CRC64;
     MTQVFQGRSF LAEKDFTRAE LEYLIDFSAH LKDLKKRGVP HHYLEGKNIA LLFEKTSTRT
     RAAFTTAAID LGAHPEYLGA NDIQLGKKES TEDTAKVLGR MFDGIEF