ID   A2MG_XYLFA              Reviewed;        1641 AA.
AC   Q9PDX7;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Alpha-2-macroglobulin {ECO:0000250|UniProtKB:P76578};
DE   Flags: Precursor;
GN   OrderedLocusNames=XF_1252;
OS   Xylella fastidiosa (strain 9a5c).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=160492;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9a5c;
RX   PubMed=10910347; DOI=10.1038/35018003;
RA   Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M.,
RA   Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S.,
RA   Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S.,
RA   Bueno M.R.P., Camargo A.A., Camargo L.E.A., Carraro D.M., Carrer H.,
RA   Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M.,
RA   Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H.,
RA   Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A., Fraga J.S.,
RA   Franca S.C., Franco M.C., Frohme M., Furlan L.R., Garnier M., Goldman G.H.,
RA   Goldman M.H.S., Gomes S.L., Gruber A., Ho P.L., Hoheisel J.D.,
RA   Junqueira M.L., Kemper E.L., Kitajima J.P., Krieger J.E., Kuramae E.E.,
RA   Laigret F., Lambais M.R., Leite L.C.C., Lemos E.G.M., Lemos M.V.F.,
RA   Lopes S.A., Lopes C.R., Machado J.A., Machado M.A., Madeira A.M.B.N.,
RA   Madeira H.M.F., Marino C.L., Marques M.V., Martins E.A.L., Martins E.M.F.,
RA   Matsukuma A.Y., Menck C.F.M., Miracca E.C., Miyaki C.Y.,
RA   Monteiro-Vitorello C.B., Moon D.H., Nagai M.A., Nascimento A.L.T.O.,
RA   Netto L.E.S., Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A.,
RA   de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A., Peixoto B.R.,
RA   Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B., Quaggio R.B.,
RA   Roberto P.G., Rodrigues V., de Rosa A.J.M., de Rosa V.E. Jr., de Sa R.G.,
RA   Santelli R.V., Sawasaki H.E., da Silva A.C.R., da Silva A.M.,
RA   da Silva F.R., Silva W.A. Jr., da Silveira J.F., Silvestri M.L.Z.,
RA   Siqueira W.J., de Souza A.A., de Souza A.P., Terenzi M.F., Truffi D.,
RA   Tsai S.M., Tsuhako M.H., Vallada H., Van Sluys M.A., Verjovski-Almeida S.,
RA   Vettore A.L., Zago M.A., Zatz M., Meidanis J., Setubal J.C.;
RT   "The genome sequence of the plant pathogen Xylella fastidiosa.";
RL   Nature 406:151-159(2000).
CC   -!- FUNCTION: Protects the bacterial cell from host peptidases.
CC       {ECO:0000250|UniProtKB:P76578}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE003849; AAF84061.1; -; Genomic_DNA.
DR   PIR; D82704; D82704.
DR   RefSeq; WP_010893758.1; NC_002488.3.
DR   AlphaFoldDB; Q9PDX7; -.
DR   SMR; Q9PDX7; -.
DR   STRING; 160492.XF_1252; -.
DR   MEROPS; I39.008; -.
DR   EnsemblBacteria; AAF84061; AAF84061; XF_1252.
DR   KEGG; xfa:XF_1252; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_000965_1_0_6; -.
DR   OMA; LDRYPYG; -.
DR   Proteomes; UP000000812; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR040639; A2MG_MG1.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR041203; Bact_A2M_MG5.
DR   InterPro; IPR041462; Bact_A2M_MG6.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17970; bMG1; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF17972; bMG5; 1.
DR   Pfam; PF17962; bMG6; 1.
DR   Pfam; PF01835; MG2; 1.
DR   PIRSF; PIRSF038980; A2M_bac; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Protease inhibitor;
KW   Reference proteome; Signal; Thioester bond.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           32..1641
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_0000036246"
FT   LIPID           32
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           32
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CROSSLNK        1166..1169
FT                   /note="Isoglutamyl cysteine thioester (Cys-Gln)"
FT                   /evidence="ECO:0000250|UniProtKB:P76578"
SQ   SEQUENCE   1641 AA;  178922 MW;  DF20B9B107364DB3 CRC64;
     MRDRVAMMLR PLVRGWIPRA VLLLTVAFSF GCNRNHNGQL PQSSGEPVAV AKEPVKGFVL
     VRAYPDQHDG ELALALEFSQ PLAATQEFDT LVRLEQDSGN HDGGWSLSDD AKTLRYPYVE
     ADKHYTVLIS AGLLAATGSR LGKPRKEPVY TGELDPVVGF ASRGSILPAR GSRGVPVVSV
     NVPEVDVEFM RVREKALPAF LARYHKAGQR SSWELSNQGN SRKRLSELAD PVYVTRFVLD
     GKKNERALTY LPIQSIRELR EPGLYFAVMK PTGSFSDAFE TAFFSVSNIG LHTRAYKDKL
     FVHTASLRSG NPYKQVDLLV LDAKGETVLQ GATDDNGNAL LNYTLNAGHV LVSRNGRDIS
     ILPFNQPALD LSEFAVAGRE NPWFDVFAWS GRDLYRPGET LRISALLRDR DGKPVKPQPV
     FLRLKQPDGK TFRETRLQPA EQGYLEFTQK IPSDAPTGRW RVEFRTDPAS KEAVQGLAVR
     VEEFLPERMK LELSSAQPVL RAKAPFTLTA DAAYLYGAPA AGNRFTANLA VAVEQHPLDN
     MPGWFFGDAT LQLPRGAKET IDITLGADGH LVHDIVLPEE AKPVSPMAVV VSGSVYESGG
     RPVTRSLKRV LWPADALVGV RPLFDVASGA DANGMARFEL TRVGVDGKPQ SAKGLKATLV
     RELRDYHWRY SDGRWDYDFT RRFENKETRT VDISTSHTTT LALPVEWGDY RLEVFDPVTG
     LTMRYPFRAG WSWGDDNRGL DARPDKVKLA LDKTSYRAGD TLKVTITPPH PGKGLLLVES
     DKPLYVQAID ANPSTTLEIP VTADWERHDV YVTALVFRGG SASNNTTPAR AVGEVYVPMQ
     RKDRRVAVGL VVPKQMRPAQ SLPVTVSVPE LAGKQAHVTI SAVDAGILNI TGFPVPDAAA
     HFFAQRRLSV DAYDIYGRVI ESFEGGTGRL KFGGDMALPP LPQAKRPTAR SQTVDLFSGA
     VKLDAKGNAH IQLPVPDFNG ALRVSALVYS DTRYGQRDAE TVVRAPILAE ASMPRVMAPG
     DRSTVTVDVQ NFTGKQGKFA VKVEGVGPLA VAEAGRSVTL GIDGKTTLNF PLRALEGNSV
     AQVRVRVEGN GSKAERHYDL PVRAAWPQGL RTQAHVLNVL APIAFDPALA KGLMPDSVNA
     RLSVSALAPI PFASVLQGVF EYPYGCAEQT ASKGYAALWL DDATIKSLGI HGVTPAQRLE
     RLEGALGRLA SLQTMNGHFS MCGGNSDVNP VLTPYIAGFL LDAKDAGFAV SDAVLQKALN
     RLSEDLLSGA HLFYGNDQSE ALMFAHQAWS GYVLARVNRA PLGTLRTLYD NERGKAVSGL
     SLVHLGVALS LQGDRKRGEA AIEAGFAKSE GGRPEVFGDY GSVIRDNALM IALVRAHGLA
     KPAYEARVMA LGRDLEARRR SGWLWLSTQE QVALAQLGRA LLVDQKKQVS GTLYVGKQRE
     EIAASRLIGR SFDAAALARG VRFVPQGDVP LYASFEVAGI PRQAPVSDDS QLLVVRRWYT
     VDGKPWTPGP LKEGQALIVR VSVTSKQNMP DALLTDLLPA GLEIDNFNLG ETRQWADVTV
     DGIALSERAN AADIKHEEFR DDRYVAMLQL TGGRTANLFY LVRAVTPGTY KVPPSLVEDM
     YRPALRGTGR VAPATVTVVQ P