OTC_STAEP
ID OTC_STAEP Reviewed; 30 AA.
AC P0C0N0; P81682;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Ornithine carbamoyltransferase;
DE Short=OTCase;
DE EC=2.1.3.3;
DE Flags: Fragment;
GN Name=argF;
OS Staphylococcus epidermidis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1282;
RN [1]
RP PROTEIN SEQUENCE.
RC STRAIN=AB9;
RA Hussain M.S., Herrmann M., Chhatwal G.S., Peters G.;
RT "A 42 kDa protein with broad affinity to bind several plasma and ECM-
RT proteins in lithium chloride extract of Staphylococcus epidermidis is
RT ornithine carbamoyltransferase.";
RL Submitted (FEB-1999) to UniProtKB.
CC -!- FUNCTION: Has vitronectin and fibronectin-binding activity.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline +
CC phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743,
CC ChEBI:CHEBI:58228; EC=2.1.3.3;
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 1/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC superfamily. OTCase family. {ECO:0000305}.
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DR AlphaFoldDB; P0C0N0; -.
DR SMR; P0C0N0; -.
DR UniPathway; UPA00068; UER00112.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001968; F:fibronectin binding; IDA:CAFA.
DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IDA:CAFA.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
PE 1: Evidence at protein level;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm;
KW Direct protein sequencing; Transferase.
FT CHAIN 1..>30
FT /note="Ornithine carbamoyltransferase"
FT /id="PRO_0000113021"
FT NON_TER 30
SQ SEQUENCE 30 AA; 3629 MW; A78EEE64FCA87A7D CRC64;
MKNLRNRSFL TLLDFSRQEV EFLLTLSEDL