ID   ASCL2_BOVIN             Reviewed;         193 AA.
AC   Q2EGB9; Q2PJC0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Achaete-scute homolog 2;
DE   AltName: Full=Mash2;
GN   Name=ASCL2; Synonyms=MASH2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16503349; DOI=10.1016/j.placenta.2005.12.001;
RA   Arnold D.R., Lefebvre R., Smith L.C.;
RT   "Characterization of the placenta specific bovine mammalian achaete scute-
RT   like homologue 2 (Mash2) gene.";
RL   Placenta 27:1124-1131(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: AS-C proteins are involved in the determination of the
CC       neuronal precursors in the peripheral nervous system and the central
CC       nervous system. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Part of a complex composed at least of ASCL2, EMSY, HCFC1,
CC       HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this
CC       complex may have a histone H3-specific methyltransferase activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta.
CC       {ECO:0000269|PubMed:16503349}.
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DR   EMBL; DQ333219; ABC49786.1; -; mRNA.
DR   EMBL; DQ381723; ABD39719.1; -; Genomic_DNA.
DR   EMBL; BC116068; AAI16069.1; -; mRNA.
DR   RefSeq; NP_001035697.1; NM_001040607.1.
DR   AlphaFoldDB; Q2EGB9; -.
DR   SMR; Q2EGB9; -.
DR   STRING; 9913.ENSBTAP00000038051; -.
DR   PaxDb; Q2EGB9; -.
DR   Ensembl; ENSBTAT00000038236; ENSBTAP00000038051; ENSBTAG00000026769.
DR   GeneID; 664650; -.
DR   KEGG; bta:664650; -.
DR   CTD; 430; -.
DR   VEuPathDB; HostDB:ENSBTAG00000026769; -.
DR   VGNC; VGNC:26207; ASCL2.
DR   eggNOG; KOG4029; Eukaryota.
DR   GeneTree; ENSGT00940000163041; -.
DR   HOGENOM; CLU_063523_2_0_1; -.
DR   InParanoid; Q2EGB9; -.
DR   OMA; ACPRESC; -.
DR   OrthoDB; 1131543at2759; -.
DR   TreeFam; TF322889; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000026769; Expressed in conceptus and 58 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0070888; F:E-box binding; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0007423; P:sensory organ development; IBA:GO_Central.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR   GO; GO:0060708; P:spongiotrophoblast differentiation; IEA:Ensembl.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR015660; MASH1/Ascl1a-like.
DR   PANTHER; PTHR13935; PTHR13935; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..193
FT                   /note="Achaete-scute homolog 2"
FT                   /id="PRO_0000247316"
FT   DOMAIN          50..102
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        20
FT                   /note="C -> S (in Ref. 1; ABC49786)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   193 AA;  20264 MW;  CFA624E5CCE336D2 CRC64;
     MDSRALPRPA PPAPGVPGCC AARRRPESPE LLRCSRRRRP GAVDPGSGAA AVARRNERER
     NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRAALAGGL
     LAPAVRHPLP RAPSGTPATA ASPSCASSSP GRGHSSEPGS PRSAYSSDDS GCEGALSPAE
     RELLDFSSWL GGY