OTO1_YEAST
ID OTO1_YEAST Reviewed; 57 AA.
AC A0A8D9PH56;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2022, sequence version 1.
DT 03-AUG-2022, entry version 2.
DE RecName: Full=Uncharacterized protein OTO1 {ECO:0000305};
DE AltName: Full=ORFan toxic when overexpressed protein 1 {ECO:0000303|PubMed:25781884};
GN Name=OTO1 {ECO:0000303|PubMed:25781884};
GN OrderedLocusNames=YGR227C-A {ECO:0000312|SGD:S000303806};
GN ORFNames=sORF2 {ECO:0000303|PubMed:25781884};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=25781884; DOI=10.1371/journal.pone.0120678;
RA Makanae K., Kintaka R., Ishikawa K., Moriya H.;
RT "Small toxic protein encoded on chromosome VII of Saccharomyces
RT cerevisiae.";
RL PLoS ONE 10:e0120678-e0120678(2015).
CC -!- FUNCTION: Proetin of unknown function whose overexpression causes
CC growth inhibition. Overexpression increases the expression of
CC ergosterol synthesis genes. {ECO:0000269|PubMed:25781884}.
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DR EMBL; BK006941; DAF84567.1; -; Genomic_DNA.
DR SGD; S000303806; OTO1.
DR Proteomes; UP000002311; Chromosome VII.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..57
FT /note="Uncharacterized protein OTO1"
FT /id="PRO_0000455987"
SQ SEQUENCE 57 AA; 6660 MW; 09C238F7F4C1F707 CRC64;
MNVRGNQCIM SIRVFLKAGE SSLSFAIKWL KRFEATTKKN QYIQNGWPLK DGNKKRK
