OTOGL_HUMAN
ID OTOGL_HUMAN Reviewed; 2353 AA.
AC Q3ZCN5; F8W0C3; Q495U8; Q8N8G5; Q8NC28;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 6.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Otogelin-like protein;
DE Flags: Precursor;
GN Name=OTOGL; Synonyms=C12orf64;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1936-2353.
RC TISSUE=Placenta, and Vascular endothelial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1959-2353.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INVOLVEMENT IN DFNB84B, VARIANT ARG-1387, AND TISSUE SPECIFICITY.
RX PubMed=23122586; DOI=10.1016/j.ajhg.2012.09.011;
RA Yariz K.O., Duman D., Seco C.Z., Dallman J., Huang M., Peters T.A.,
RA Sirmaci A., Lu N., Schraders M., Skromne I., Oostrik J., Diaz-Horta O.,
RA Young J.I., Tokgoz-Yilmaz S., Konukseven O., Shahin H., Hetterschijt L.,
RA Kanaan M., Oonk A.M., Edwards Y.J., Li H., Atalay S., Blanton S.,
RA Desmidt A.A., Liu X.Z., Pennings R.J., Lu Z., Chen Z.Y., Kremer H.,
RA Tekin M.;
RT "Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause
RT moderate sensorineural hearing loss.";
RL Am. J. Hum. Genet. 91:872-882(2012).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] PHE-2297.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC Q3ZCN5; P42858: HTT; NbExp=3; IntAct=EBI-25954043, EBI-466029;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in fetal inner ear and
CC heart. Low levels in fetal skeletal muscle, kidney, spleen and colon.
CC Not detected in fetal liver, lung, brain, nor in fetal stomach. In
CC adult tissues, highest levels in brain, kidney, heart and retina.
CC Relatively low levels in lung, spleen and duodenum. Not detected in
CC adult skeletal muscle, liver, nor testis.
CC {ECO:0000269|PubMed:23122586}.
CC -!- DISEASE: Deafness, autosomal recessive, 84B (DFNB84B) [MIM:614944]: A
CC form of non-syndromic deafness characterized by congenital, non-
CC progressive, sensorineural, symmetric hearing loss. Vestibular
CC hypofunction is rarely observed. {ECO:0000269|PubMed:23122586}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the otogelin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI01018.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI01019.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04877.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC11376.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC078817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC083812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK075060; BAC11376.1; ALT_INIT; mRNA.
DR EMBL; AK096852; BAC04877.1; ALT_INIT; mRNA.
DR EMBL; BC101017; AAI01018.3; ALT_INIT; mRNA.
DR EMBL; BC101018; AAI01019.2; ALT_INIT; mRNA.
DR AlphaFoldDB; Q3ZCN5; -.
DR IntAct; Q3ZCN5; 1.
DR STRING; 9606.ENSP00000400895; -.
DR GlyGen; Q3ZCN5; 8 sites.
DR iPTMnet; Q3ZCN5; -.
DR PhosphoSitePlus; Q3ZCN5; -.
DR BioMuta; OTOGL; -.
DR DMDM; 449081296; -.
DR jPOST; Q3ZCN5; -.
DR MassIVE; Q3ZCN5; -.
DR PaxDb; Q3ZCN5; -.
DR PeptideAtlas; Q3ZCN5; -.
DR PRIDE; Q3ZCN5; -.
DR TopDownProteomics; Q3ZCN5; -.
DR Antibodypedia; 51688; 15 antibodies from 8 providers.
DR Ensembl; ENST00000547103.7; ENSP00000447211.2; ENSG00000165899.12.
DR MANE-Select; ENST00000547103.7; ENSP00000447211.2; NM_001378609.3; NP_001365538.2.
DR UCSC; uc058rih.1; human.
DR GeneCards; OTOGL; -.
DR HGNC; HGNC:26901; OTOGL.
DR HPA; ENSG00000165899; Tissue enhanced (heart muscle, kidney).
DR MalaCards; OTOGL; -.
DR MIM; 614925; gene.
DR MIM; 614944; phenotype.
DR neXtProt; NX_Q3ZCN5; -.
DR OpenTargets; ENSG00000165899; -.
DR Orphanet; 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR VEuPathDB; HostDB:ENSG00000165899; -.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160698; -.
DR HOGENOM; CLU_000076_0_0_1; -.
DR InParanoid; Q3ZCN5; -.
DR TreeFam; TF330609; -.
DR PathwayCommons; Q3ZCN5; -.
DR Reactome; R-HSA-9662361; Sensory processing of sound by outer hair cells of the cochlea.
DR SignaLink; Q3ZCN5; -.
DR ChiTaRS; OTOGL; human.
DR Pharos; Q3ZCN5; Tbio.
DR PRO; PR:Q3ZCN5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q3ZCN5; protein.
DR Bgee; ENSG00000165899; Expressed in right atrium auricular region and 99 other tissues.
DR ExpressionAtlas; Q3ZCN5; baseline and differential.
DR Genevisible; Q3ZCN5; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR InterPro; IPR007934; AbfB_ABD.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR030110; Otogl.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF225; PTHR11339:SF225; 1.
DR Pfam; PF05270; AbfB; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; SSF110221; 1.
DR SUPFAM; SSF57567; SSF57567; 4.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 1: Evidence at protein level;
KW Deafness; Disulfide bond; Glycoprotein; Non-syndromic deafness;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..2353
FT /note="Otogelin-like protein"
FT /id="PRO_0000316765"
FT DOMAIN 121..297
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 390..443
FT /note="TIL 1"
FT DOMAIN 481..654
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 745..800
FT /note="TIL 2"
FT DOMAIN 946..1115
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1534..1723
FT /note="VWFD 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 2261..2353
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 434
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 826
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 876
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1604
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 123..257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 145..296
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 483..618
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 505..653
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 527..535
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 948..1078
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 992..999
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1536..1683
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2261..2317
FT /evidence="ECO:0000250"
FT DISULFID 2282..2331
FT /evidence="ECO:0000250"
FT DISULFID 2293..2348
FT /evidence="ECO:0000250"
FT DISULFID 2297..2350
FT /evidence="ECO:0000250"
FT VARIANT 1387
FT /note="C -> R (in dbSNP:rs768182016)"
FT /evidence="ECO:0000269|PubMed:23122586"
FT /id="VAR_069040"
FT VARIANT 2297
FT /note="C -> F (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_038388"
FT CONFLICT 2083
FT /note="I -> V (in Ref. 3; AAI01018/AAI01019 and 2;
FT BAC04877)"
FT /evidence="ECO:0000305"
FT CONFLICT 2141
FT /note="A -> T (in Ref. 3; AAI01018/AAI01019 and 2;
FT BAC04877)"
FT /evidence="ECO:0000305"
FT CONFLICT 2246
FT /note="N -> S (in Ref. 3; AAI01018/AAI01019 and 2;
FT BAC11376)"
FT /evidence="ECO:0000305"
FT CONFLICT 2274
FT /note="K -> E (in Ref. 2; BAC04877)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2353 AA; 264612 MW; 511F289FF1FD4DA4 CRC64;
MNIVRKLNLM IPWSIFLLHV LLFSLQEYIC ASSILMGTSK NGFNENRQKR ALLAAQFEAT
SPRYFFHDAI NWGESKIKGS CPYECLNGAF CSKTGTCDCQ IFQALGTRCQ IIPNMGNGRD
GICKTWGQYH FETFDGIYYY FPGNCSYIFA KDCGDLEPRY TVWVHNSPKC LGSVYSCYRS
ISLFFSNQEE IRIYGHEIKK NGISLTLPQT IGQIFIEKLA DYILVKTTFG FSLAWDGISG
IYLKLSEDHK GKSCGLCGNY NDIQSDDFII LQEDYTEDIA MFANSWSVQT PDDTKCVLTP
SDFPNPCSSG MPAFEAIFFK CQILLQFPFL SCHEYIDPYL YIASCVNDLC KTDDDETYCR
AATEYARACS HAGYPIQDWR DDFPACTDKC DDSFVHRDCI SCCPPTCTFE KQCLGSNLHC
LDGCYCPDGL VMDNGTCISL ENCPCGFHGL AYSVGSKIEQ ECTECVCVGG VWNCTEQDCP
VQCSVVGDSH FTTFDGRHYS FIGMCQYILV KGTGKDKFTI TLQKAPCEQN LGLVCLQSIT
LILEDDFNKQ VTLGRGGQIL TSPNQGFNLN GIVEIQTLSS LFILLKTTFG LKILFAIDGE
RIYIQLTSAW KRRTLGLCGT FNGNIRDDFL SPSGMIEGTP QLHANAWRVS STCFAPVHVP
VVDPCNINQQ NIGYAAHCDV IHQELFAPCH IYISPGLYYQ LCRHDACKCG SSCLCNALAH
YAYLCGQHGV PIDFRTQISF CAVVCQKGML YHHCSSFCLH SCISLSSPEQ CSDDCAEGCN
CPEGKFYEDT LNFCVPIFHC RCHYRGSVYQ PGELIPTPSG LCQCSNGTVK CDELATPSAV
HICPEGKEYF DCRFPDPELP AGGVNCETTC ANLAMNFTCT PSSPCISGCV CAPGMAEHRG
KCYVPESCPC IWKDWEYLSG EVIATPCYTC VCRRGMFNCT YYPCPAVCTI YGDRHYYSFD
GLEYDYISDC QVFLIKSADD SDISVIAQNK KCFDNDIVCS KSVLISVGDT EIYLNDTPYK
QKQSGFFLEN KSTYQLWKAG YYIVVYFPEK DITILWDRKT TIHIKVGPQW KNKLSGLCGN
FDKCTSNDMT TSNNLEVRNA RVFGDSWALG QCESPDETIK PCEAHQNKFP YAKKECSILY
SDIFASCRNV IDVTSFAKNC HEDTCNCNLG GDCECLCTSI AAYAYKCCQE GISIHWRSST
VCSLDCEYYN EGLGEGPYML ASYGQSGLVL GANMTSRSVF CLPRSSVHTS LFFYFMITPG
LFKEKVSSLA LVSLESAERP NYFLYVHDND TLSLELWEAN SAFHRRATFF HHQGLWIPGY
SAFELYSKKG FFIIFTDSSV KASKYDDSEE FKHSSSFSIE EIQAAVPYRK MCEWRYEPCA
TPCFKTCSDP EALACKFLPP VEGCLPYCPK NMILDEVTLK CVYPRDCIPV IPTEPTLMPP
AKPTVPMFTV WEMITPSDIT VFDMLTPTTG LECEPQKFDP VYDCSQYICL NMEWQLYNWS
LNCPKDVEMP DCGFRGRPVQ VNSDICCPEW ECPCRCSMLS ELSIITFDGN NAALYSMASY
ILVRIPGEII VAHIEKCSMN QNGNSLKKLA PSGRISGLCF KKLNVTTPIH KIIVNRLARK
VEVDSIVVPL PFSSQELSIE DSGSMYVITT PAGLIIKWSH LTGIIDIHFG FRFNLSSYTE
GLCGICNEDP DDDLRMQNGT IITNMEDIGL FIESWEIEKS FEVTMRRPVR NCTEHDCSQC
IDLLNRRIFI PCHDKVSPED FCEKMWINYT YFWNYECDAL SAYVALCNKF DICIQWRTPD
YCSLSCPEGK EYQPCVRPCE ARTCLNQWFY GHTSCLNLRE DCVCKVGTIL HRPHSAQCIP
EKECACTDSE DQPRTAGEIW NGGIDECTLY KCLENGSIIP IEPDCDEEPT PVCEREAEVV
MGIIDKWTCC SKEVCGCDTT LCETSIPTCT NSQKLIVGHS PLSCCPQYKC ECDPLKCPSI
STPECREDQF MIQVRQEEPC CFSPFCVCES CTKPVPLCHD GEFLTVDLNS THFCCPQYYC
VCEPNLCPMP LLNCAEDMNL VKENVSGQCC PTWHCECNCE NLIMPTCEVG EFTAIDHNFQ
SDCGCIQYLC EKDDVCVFQE VSVLNPGQSM IKYLEEDFCY AIECLEEKDN HTGFHTLNFT
LVNCSKKCDV HQVYTPSPSD YGCCGTCKNV SCKFHMENGT SVVYAVGSTW HYNCTTYECV
KTDEGAIILN YTMVCPPFNE TECKMNEGIV KLYNEGCCKI CKREERICQK VIIKSVIRKQ
DCMSQSPINV ASCDGKCPSA TIYNINIESH LRFCKCCREN GVRNLSVPLY CSGNGTEIMY
TLQEPIDCTC QWN
