OTOGL_MOUSE
ID OTOGL_MOUSE Reviewed; 2325 AA.
AC F7A4A7; D3JEN5;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Otogelin-like protein;
DE Flags: Precursor;
GN Name=Otogl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cochlea;
RX PubMed=20472657; DOI=10.1136/jmg.2009.075697;
RA Shahin H., Rahil M., Abu Rayan A., Avraham K.B., King M.C., Kanaan M.,
RA Walsh T.;
RT "Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human
RT hearing loss DFNB84.";
RL J. Med. Genet. 47:643-645(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=23122586; DOI=10.1016/j.ajhg.2012.09.011;
RA Yariz K.O., Duman D., Seco C.Z., Dallman J., Huang M., Peters T.A.,
RA Sirmaci A., Lu N., Schraders M., Skromne I., Oostrik J., Diaz-Horta O.,
RA Young J.I., Tokgoz-Yilmaz S., Konukseven O., Shahin H., Hetterschijt L.,
RA Kanaan M., Oonk A.M., Edwards Y.J., Li H., Atalay S., Blanton S.,
RA Desmidt A.A., Liu X.Z., Pennings R.J., Lu Z., Chen Z.Y., Kremer H.,
RA Tekin M.;
RT "Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause
RT moderate sensorineural hearing loss.";
RL Am. J. Hum. Genet. 91:872-882(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F7A4A7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F7A4A7-2; Sequence=VSP_045177;
CC -!- DEVELOPMENTAL STAGE: At 17.5 dpc, primarily detected in the spiral
CC prominence and the Claudius cells and weakly in hair cells (at protein
CC level). Also detected in the lumen surface of interdental cells in the
CC proximity of Reissner's membrane and at the base of nascent tectorial
CC membrane (at protein level). Similar expression pattern in P0 cochlea,
CC with additional detection in some supporting cells (at protein level).
CC At the same stage, in saccule, weakly expressed in hair cells and more
CC prominently in the saccular roof (at protein level). By P6, expression
CC becomes more restricted. Mainly detected in the outer hair cells,
CC Deiter's cells and Claudius cells (at protein level). In the tectorial
CC membrane, localized to the base. In the saccule, detected at high
CC levels in the saccule roof with little change in the hair cells (at
CC protein level). {ECO:0000269|PubMed:23122586}.
CC -!- SIMILARITY: Belongs to the otogelin family. {ECO:0000305}.
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DR EMBL; GU140005; ADC39942.1; -; mRNA.
DR EMBL; AC113439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC123948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56747.1; -. [F7A4A7-1]
DR RefSeq; NP_001171038.1; NM_001177567.1. [F7A4A7-1]
DR AlphaFoldDB; F7A4A7; -.
DR SMR; F7A4A7; -.
DR BioGRID; 554738; 1.
DR STRING; 10090.ENSMUSP00000129467; -.
DR GlyGen; F7A4A7; 7 sites.
DR PhosphoSitePlus; F7A4A7; -.
DR PaxDb; F7A4A7; -.
DR PRIDE; F7A4A7; -.
DR Antibodypedia; 51688; 15 antibodies from 8 providers.
DR DNASU; 628870; -.
DR Ensembl; ENSMUST00000165341; ENSMUSP00000129467; ENSMUSG00000091455. [F7A4A7-1]
DR GeneID; 628870; -.
DR KEGG; mmu:628870; -.
DR UCSC; uc011xnc.1; mouse. [F7A4A7-1]
DR CTD; 283310; -.
DR MGI; MGI:3647600; Otogl.
DR VEuPathDB; HostDB:ENSMUSG00000091455; -.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160698; -.
DR HOGENOM; CLU_000076_0_0_1; -.
DR InParanoid; F7A4A7; -.
DR OMA; EAPPCDN; -.
DR OrthoDB; 12226at2759; -.
DR PhylomeDB; F7A4A7; -.
DR TreeFam; TF330609; -.
DR BioGRID-ORCS; 628870; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Otogl; mouse.
DR PRO; PR:F7A4A7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; F7A4A7; protein.
DR Bgee; ENSMUSG00000091455; Expressed in cochlear duct of membranous labyrinth and 10 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR InterPro; IPR007934; AbfB_ABD.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR030110; Otogl.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF225; PTHR11339:SF225; 1.
DR Pfam; PF05270; AbfB; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; SSF110221; 1.
DR SUPFAM; SSF57567; SSF57567; 5.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..2325
FT /note="Otogelin-like protein"
FT /id="PRO_0000421106"
FT DOMAIN 112..288
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 472..645
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 736..791
FT /note="TIL 1"
FT DOMAIN 937..1114
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1366..1418
FT /note="TIL 2"
FT DOMAIN 1506..1695
FT /note="VWFD 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 2233..2325
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT CARBOHYD 425
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 817
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 867
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1280
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1576
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..248
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 136..287
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 474..609
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 496..644
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 518..526
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 939..1069
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 961..1113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 983..990
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1508..1655
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1549..1571
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2233..2289
FT /evidence="ECO:0000250"
FT DISULFID 2254..2303
FT /evidence="ECO:0000250"
FT DISULFID 2265..2320
FT /evidence="ECO:0000250"
FT DISULFID 2269..2322
FT /evidence="ECO:0000250"
FT VAR_SEQ 2258..2325
FT /note="SSISVASCDGKCPSATIYNINVESHLRFCKCCRENGVRNVTVPLHCSGNGTE
FT VMYTLQEPIDCTCQWN -> RLVWHLVMGNARQLPYITSMLKVT (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:20472657"
FT /id="VSP_045177"
SQ SEQUENCE 2325 AA; 260929 MW; 9E446F218E3F091A CRC64;
MVPWRALSLP ILLVSLRGYV CASSVLSETS ESEFYENEQR RALLAVQFEA TSPRYFFHEA
INWGESKIKG SCPHECLNGA FCSKTGTCDC QIFQALGTRC QIVPNMGSGR DGICKTWGQY
HFETFDGIYY YFPGSCSYIF AKDCGNLEPQ YTVWVHNSPK CLGSVYSCYR SISLFFSNQE
EIRIYGHEIR KNGISLSLPQ TLGQVHLEKV ADYILVKTTF GFSLAWDGIS GIYLKLSEEH
RGKSCGLCAN YNGIQSDDFV ILQEDYTEDI AMFANSWLVL TPDDTKCVPT PSDFPNPCSS
GMPAFEAIFF KCQILLQFPF LSCHEYIDPY LYIASCVNDL CKTDDDETYC RAATEYARAC
SHAGFPIQDW RDDFPACTDK CDDSFVHRDC ISCCPPSCTF EKQCLGSNLH CLDGCYCADG
LIMDNGTCIS LESCPCSFHG LAYSVGSKIE QECTECVCVG GVWNCTEHDC PVQCSVVGDS
HFTTFDGRHY SFIGLCQYIL VKGTGKDRFT ITLQKAHCEQ NLGLVCLQSI TLILEDDFNK
QVTLSRGGQI VTSPNQGFTL NGIVEIQTLS SLFILLRTTF GLKILFAIDG ERIYIQLSSA
WKRRTLGLCG TFNGNIRDDF LSPSGMIEGT PQLHAHAWRV SSTCFAPVHV PMVDPCNINQ
QNIGYAAHCD VIHQELFAPC HVYVSPGLYY QLCRHDACKC GSPCLCNALA HYAYLCGQRG
VPIDFRAHIS FCAVVCQKGM LYHHCSSLCL RSCTSLSSPE QCKDDCAEGC NCPEGKFYEE
TLNFCVPIYH CRCHYRGSIY QPGELIPTPS GLCQCSNGTV KCDELATPST VHACPEGKEY
FDCRFPDPAL PAGGINCETT CANLAMNFTC APSSPCISGC VCAAGMAEHK GKCYVPESCP
CIWKDWEYSS GEVISTPCYT CVCRRGMFNC TYYPCPAVCT VYGDRHYHSF DGLEYDYISD
CQVFLIKSTD DSDISVISQN KKCFDNDIVC SKSVLISIGD TEIYLNDAPY KQKRSGFFLE
SRPEYQLWKA GFYIVIYFPE EDITILWDEK TTIHIKVGPQ WKNKLAGLCG NFDKCTSNDM
TTSNNIEVRN AQVFGDSWAL GQCEDLMEAL KPCEAHQNKF PYAKRECSIL YSDVFAPCRN
VIDVTSFAKN CHEDTCNCNL GGDCECLCTS VAAYAYKCCQ EGVPVHWRSP TVCALDCEYY
NQGLGEGPYM LASYGQSGLV LGANMTSRSV FSLPRSNNRG NLFFIFMITP GLFKEKTSSL
ALVSLESAER PNYFLYVHDN DTLSLKLWRA NSEFHQRATF FHHQGLWIPG YSAFELYSKK
GYFIVFMGSS VKASKYDDSE EFKQSSSFSI EEIQAVVPYR RMCEWRYEPC ATPCFKTCSD
PEALACTFLP PVEGCLPYCP KNMILDETTL KCVHPEDCIP LFPTEPALPP DITPSDMTPT
PGLECEPQQF DPVYNCSQYI CLNMEWTFYN WSLNCPKDLE MPDCGFRGWP VQVNTDICCP
EWECPCRCSM LSELSIITFD GNSAALSSMA SYILVRVPGE IVVVHIDKCS MNQNGHALKK
PASFGRISGL CFKKLNVTTS IHKILINRVV RKVDVDSIVV PLPFSSHELF IEDSGTMYVI
TTPAGLIIKW AHLTGIIDIH FGPQFNLSSY TEGLCGICND NPDDDLRMQN GTIITNMEDI
ELFIGSWEIE KSFEVTMRRP VRNCTEYDCS HCIELLNREG FIPCHDKVSP RDFCEKMWIN
YTYFWSYECD AISAYVALCN KFDICIQWRT PDYCPLSCPE GKEYQPCVRP CEARTCLNKW
FYGHSSCLNL REDCVCKNGT ILHRPDKTLC IPEQECVCTD REEHPRSAGE IWNGGIDECT
LYKCLEDGNI IPIEPVCEEE PSPICERTAE VVIGIVDKLT CCSKKVCGCD MSLCDRTIPP
CTNSQKLIVG YSALSCCPQY ECECDTVRCP DISTPVCRDD QFVLQVRQGE PCCFYPSCVC
KTCTEPTPQC TDGEFLTVNI NTTHLCCPQY YCVCEPDLCP PPSLECAKDM NLVKENVSGQ
CCPNWRCECN CETLVMPTCD VGEFAAIDQN FQTDCGCVQY LCEKDDVCVF QEVSVLNPGQ
SLIKYLEEEF CYIIECLDEK DNYTDFHTLN VTMVNCSKDC DAHQIYIPSS SDYDCCGTCK
NISCKFIMEN GTSVIYEEGS TWHYNCSTYE CVNTEEGATI LNYSMVCPPF NETECKLNEG
IVKLYNEGCC KICKREERIC QKVIIKSIIK KQDCVSQSSI SVASCDGKCP SATIYNINVE
SHLRFCKCCR ENGVRNVTVP LHCSGNGTEV MYTLQEPIDC TCQWN
