OTOG_HUMAN
ID OTOG_HUMAN Reviewed; 2925 AA.
AC Q6ZRI0; A8MTX6; A8MUJ0; B7WPC4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Otogelin;
DE Flags: Precursor;
GN Name=OTOG; Synonyms=OTGN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP VARIANT DFNB18B LEU-2116.
RX PubMed=23122587; DOI=10.1016/j.ajhg.2012.09.012;
RA Schraders M., Ruiz-Palmero L., Kalay E., Oostrik J., del Castillo F.J.,
RA Sezgin O., Beynon A.J., Strom T.M., Pennings R.J., Seco C.Z., Oonk A.M.,
RA Kunst H.P., Dominguez-Ruiz M., Garcia-Arumi A.M., del Campo M.,
RA Villamar M., Hoefsloot L.H., Moreno F., Admiraal R.J., del Castillo I.,
RA Kremer H.;
RT "Mutations of the gene encoding otogelin are a cause of autosomal-recessive
RT nonsyndromic moderate hearing impairment.";
RL Am. J. Hum. Genet. 91:883-889(2012).
RN [4]
RP VARIANT VAL-1089.
RX PubMed=26733463; DOI=10.1136/jmedgenet-2015-103620;
RA Watson C.M., Crinnion L.A., Murphy H., Newbould M., Harrison S.M.,
RA Lascelles C., Antanaviciute A., Carr I.M., Sheridan E., Bonthron D.T.,
RA Smith A.;
RT "Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal
RT akinesia.";
RL J. Med. Genet. 53:264-269(2016).
CC -!- FUNCTION: Glycoprotein specific to acellular membranes of the inner
CC ear. May be required for the anchoring of the otoconial membranes and
CC cupulae to the underlying neuroepithelia in the vestibule. May be
CC involved in the organization and/or stabilization of the fibrillar
CC network that compose the tectorial membrane in the cochlea. May play a
CC role in mechanotransduction processes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:O55225}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O55225}; Extracellular side
CC {ECO:0000250|UniProtKB:O55225}. Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O55225}. Note=Found in fiber-like structures
CC during the maturation process of the tectorial membrane.
CC {ECO:0000250|UniProtKB:O55225}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZRI0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZRI0-2; Sequence=VSP_029709, VSP_029710, VSP_029711,
CC VSP_029712, VSP_029713, VSP_029714;
CC -!- PTM: N-glycosylated. Not O-glycosylated. {ECO:0000250}.
CC -!- DISEASE: Deafness, autosomal recessive, 18B (DFNB18B) [MIM:614945]: A
CC form of non-syndromic deafness characterized by a moderate hearing
CC impairment, which can be associated with vestibular dysfunction, and a
CC flat to shallow 'U' or slightly downsloping shaped audiograms.
CC {ECO:0000269|PubMed:23122587}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the otogelin family. {ECO:0000305}.
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DR EMBL; AK128214; BAC87330.1; -; mRNA.
DR EMBL; AC124799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS76390.1; -. [Q6ZRI0-1]
DR RefSeq; NP_001264198.1; NM_001277269.1. [Q6ZRI0-1]
DR SMR; Q6ZRI0; -.
DR BioGRID; 131110; 1.
DR STRING; 9606.ENSP00000382323; -.
DR CarbonylDB; Q6ZRI0; -.
DR GlyGen; Q6ZRI0; 5 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q6ZRI0; -.
DR PhosphoSitePlus; Q6ZRI0; -.
DR BioMuta; OTOG; -.
DR DMDM; 215274227; -.
DR MassIVE; Q6ZRI0; -.
DR PaxDb; Q6ZRI0; -.
DR PeptideAtlas; Q6ZRI0; -.
DR PRIDE; Q6ZRI0; -.
DR Antibodypedia; 77421; 8 antibodies from 2 providers.
DR DNASU; 340990; -.
DR Ensembl; ENST00000399391.7; ENSP00000382323.2; ENSG00000188162.12. [Q6ZRI0-1]
DR GeneID; 340990; -.
DR KEGG; hsa:340990; -.
DR UCSC; uc001mnh.1; human. [Q6ZRI0-1]
DR CTD; 340990; -.
DR DisGeNET; 340990; -.
DR GeneCards; OTOG; -.
DR HGNC; HGNC:8516; OTOG.
DR HPA; ENSG00000188162; Tissue enhanced (pituitary).
DR MalaCards; OTOG; -.
DR MIM; 604487; gene.
DR MIM; 614945; phenotype.
DR neXtProt; NX_Q6ZRI0; -.
DR OpenTargets; ENSG00000188162; -.
DR Orphanet; 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR VEuPathDB; HostDB:ENSG00000188162; -.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000157490; -.
DR HOGENOM; CLU_248357_0_0_1; -.
DR InParanoid; Q6ZRI0; -.
DR OrthoDB; 12226at2759; -.
DR PhylomeDB; Q6ZRI0; -.
DR TreeFam; TF300299; -.
DR PathwayCommons; Q6ZRI0; -.
DR Reactome; R-HSA-9662361; Sensory processing of sound by outer hair cells of the cochlea.
DR BioGRID-ORCS; 340990; 6 hits in 1021 CRISPR screens.
DR ChiTaRS; OTOG; human.
DR GenomeRNAi; 340990; -.
DR Pharos; Q6ZRI0; Tdark.
DR PRO; PR:Q6ZRI0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6ZRI0; protein.
DR Bgee; ENSG00000188162; Expressed in ventricular zone and 18 other tissues.
DR ExpressionAtlas; Q6ZRI0; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:InterPro.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR InterPro; IPR007934; AbfB_ABD.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR030105; Otogelin.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF228; PTHR11339:SF228; 1.
DR Pfam; PF05270; AbfB; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; SSF110221; 1.
DR SUPFAM; SSF57567; SSF57567; 4.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Deafness; Disease variant;
KW Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW Non-syndromic deafness; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..2925
FT /note="Otogelin"
FT /id="PRO_0000312148"
FT DOMAIN 102..139
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 150..322
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 512..688
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 780..844
FT /note="TIL"
FT /evidence="ECO:0000255"
FT DOMAIN 984..1152
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 2110..2289
FT /note="VWFD 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 2840..2925
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 39..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1693..1715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..1788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1643..1679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1693..1713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1749..1763
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 914
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1478
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1612
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..120
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 114..126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 128..138
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 152..285
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 199..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 514..652
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 536..687
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 558..566
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 986..1115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1030..1037
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2112..2249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2840..2889
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 2854..2903
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 2865..2920
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 2869..2922
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT VAR_SEQ 1..985
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029709"
FT VAR_SEQ 986..1014
FT /note="CTAYGDRHYRTFDGLPFDFVGACKVHLVK -> MFPARGVPLHLEGEGVFPW
FT GPGDVSLPYL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029710"
FT VAR_SEQ 1240..1249
FT /note="PYDCDFFNKV -> L (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029711"
FT VAR_SEQ 2434..2575
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029712"
FT VAR_SEQ 2644
FT /note="E -> G (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029713"
FT VAR_SEQ 2645..2925
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029714"
FT VARIANT 375
FT /note="T -> S (in dbSNP:rs7130190)"
FT /id="VAR_037406"
FT VARIANT 391
FT /note="A -> D (in dbSNP:rs61611064)"
FT /id="VAR_061161"
FT VARIANT 659
FT /note="T -> M (in dbSNP:rs7112749)"
FT /id="VAR_037407"
FT VARIANT 692
FT /note="S -> P (in dbSNP:rs7106548)"
FT /id="VAR_037408"
FT VARIANT 919
FT /note="A -> T (in dbSNP:rs2355466)"
FT /id="VAR_037409"
FT VARIANT 1075
FT /note="R -> Q (in dbSNP:rs11024333)"
FT /id="VAR_037410"
FT VARIANT 1089
FT /note="I -> V (in dbSNP:rs56359117)"
FT /evidence="ECO:0000269|PubMed:26733463"
FT /id="VAR_084731"
FT VARIANT 1112
FT /note="A -> V (in dbSNP:rs7936324)"
FT /id="VAR_037411"
FT VARIANT 1129
FT /note="P -> L (in dbSNP:rs7936354)"
FT /id="VAR_037412"
FT VARIANT 1399
FT /note="A -> G (in dbSNP:rs4491195)"
FT /id="VAR_037413"
FT VARIANT 1646
FT /note="P -> L (in dbSNP:rs1256306888)"
FT /id="VAR_037414"
FT VARIANT 1832
FT /note="A -> V (in dbSNP:rs1003490)"
FT /id="VAR_037415"
FT VARIANT 1947
FT /note="T -> M (in dbSNP:rs7111528)"
FT /id="VAR_037416"
FT VARIANT 2006
FT /note="A -> V (in dbSNP:rs11024341)"
FT /id="VAR_047262"
FT VARIANT 2116
FT /note="P -> L (in DFNB18B; dbSNP:rs397514607)"
FT /evidence="ECO:0000269|PubMed:23122587"
FT /id="VAR_069250"
FT VARIANT 2750
FT /note="R -> Q (in dbSNP:rs12422210)"
FT /id="VAR_037417"
FT VARIANT 2909
FT /note="W -> S (in dbSNP:rs11024357)"
FT /id="VAR_037418"
FT CONFLICT 1375
FT /note="A -> P (in Ref. 1; BAC87330)"
FT /evidence="ECO:0000305"
FT CONFLICT 2121
FT /note="V -> A (in Ref. 1; BAC87330)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2925 AA; 314794 MW; D3555CAA3D9AE5FA CRC64;
MGVLASALCW LLCVWLPWGE QAAESLRVQR LGERVVDSGR SGARGMRNVK GMRNGPAQTR
VSSSSSHQEA TLAMGDKATV VGGQQAEAPD SVAMSSWERR LHRAKCAPSY LFSCFNGGEC
VHPAFCDCRR FNATGPRCQM VYNAGPERDS ICRAWGQHHV ETFDGLYYYL SGKGSYTLVG
RHEPEGQSFS IQVHNDPQCG SSPYTCSRAV SLFFVGEQEI HLAKEVTHGG MRVQLPHVMG
SARLQQLAGY VIVRHQSAFT LAWDGASAVY IKMSPELLGW THGLCGNNNA DPKDDLVTSS
GKLTDDVVEF VHSWQEQAPN QPPGPTTSSL PRPPCLQQNP GTMQGVYEQC EALLRPPFDA
CHAYVSPLPF TASCTSDLCQ SMGDVATWCR ALAEYARACA QAGRPLQGWR TQLRQCTVHC
KEKAFTYNEC IACCPASCHP RASCVDSEIA CVDGCYCPNG LIFEDGGCVA PAECPCEFHG
TLYPPGSVVK EDCNTCTCTS GKWECSTAVC PAECSVTGDI HFTTFDGRRY TFPATCQYIL
AKSRSSGTFT VTLQNAPCGL NQDGACVQSV SVILHQDPRR QVTLTQAGDV LLFDQYKIIP
PYTDDAFEIR RLSSVFLRVR TNVGVRVLYD REGLRLYLQV DQRWVEDTVG LCGTFNGNTQ
DDFLSPVGVP ESTPQLFGNS WKTLSACSPL VSGSPLDPCD VHLQAASYSV QACSVLTGEM
FAPCSAFLSP VPYFEQCRRD ACRCGQPCLC ATLAHYAHLC RRHGLPVDFR ARLPACALSC
EASKEYSPCV APCGRTCQDL ASPEACGVDG GDDLSRDECV EGCACPPDTY LDTQADLCVP
RNQCSCHFQG VDYPPGDSDI PSLGHCHCKD GVMSCDSRAP AAACPAGQVF VNCSDLHTDL
ELSRERTCEQ QLLNLSVSAR GPCLSGCACP QGLLRHGDAC FLPEECPCTW KGKEYFPGDQ
VMSPCHTCVC QRGSFQCTLH PCASTCTAYG DRHYRTFDGL PFDFVGACKV HLVKSTSDVS
FSVIVENVNC YSSGMICRKF ISINVGNSLI VFDDDSGNPS PESFLDDKQE VHTWRVGFFT
LVHFPQEHIT LLWDQRTTVH VQAGPQWQGQ LAGLCGNFDL KTINEMRTPE NLELTNPQEF
GSSWAAVECP DTLDPRDMCV LNPLREPFAK KECSILLSEV FEICHPVVDV TWFYSNCLTD
TCGCSQGGDC ECFCASVSAY AHQCCQHGVA VDWRTPRLCP YDCDFFNKVL GKGPYQLSSL
AAGGALVGMK AVGDDIVLVR TEDVAPADIV SFLLTAALYK AKAHDPDVVS LEAADRPNFF
LHVTANGSLE LAKWQGRDTF QQHASFLLHR GTRQAGLVAL ESLAKPSSFL YVSGAVLALR
LYEHTEVFRR GTLFRLLDAK PSGAAYPICE WRYDACASPC FQTCRDPRAA SCRDVPRVEG
CVPVCPTPQV LDEVTQRCVY LEDCVEPAVW VPTEALGNET LPPSQGLPTP SDEEPQLSQE
SPRTPTHRPA LTPAAPLTTA LNPPVTATEE PVVSPGPTQT TLQQPLELTA SQLPAGPTES
PASKGVTASL LAIPHTPESS SLPVALQTPT PGMVSGAMET TRVTVIFAGS PNITVSSRSP
PAPRFPLMTK AVTVRGHGSL PVRTTPPQPS LTASPSSRPV ASPGAISRSP TSSGSHKAVL
TPAVTKVISR TGVPQPTQAQ SASSPSTPLT VAGTAAEQVP VSPLATRSLE IVLSTEKGEA
GHSQPMGSPA SPQPHPLPSA PPRPAQHTTM ATRSPALPPE TPAAASLSTA TDGLAATPFM
SLESTRPSQL LSGLPPDTSL PLAKVGTSAP VATPGPKASV ITTPLQPQAT TLPAQTLSPV
LPFTPAAMTQ AHPPTHIAPP AAGTAPGLLL GATLPTSGVL PVAEGTASMV SVVPRKSTTG
KVAILSKQVS LPTSMYGSAE GGPTELTPAT SHPLTPLVAE PEGAQAGTAL PVPTSYALSR
VSARTAPQDS MLVLLPQLAE AHGTSAGPHL AAEPVDEATT EPSGRSAPAL SIVEGLAEAL
ATTTEANTST TCVPIAEQDC VRHICLEGQL IRVNQSQHCP QGAAPPRCGI LGLAVRVGGD
RCCPLWECAC RCSIFPDLSF VTFDGSHVAL FKEAIYILSQ SPDEMLTVHV LDCKSANLGH
LNWPPFCLVM LNMTHLAHQV TIDRFNRKVT VDLQPVWPPV SRYGFRIEDT GHMYMILTPS
DIQIQWLHSS GLMIVEASKT SKAQGHGLCG ICDGDAANDL TLKDGSVVGG AEDPAPFLDS
WQVPSSLTSV GQTRFRPDSC ATTDCSPCLR MVSNRTFSAC HRFVPPESFC ELWIRDTKYV
QQPCVALTVY VAMCHKFHVC IEWRRSDYCP FLCSSDSTYQ ACVTACEPPK TCQDGILGPL
DPEHCQVLGE GCVCSEGTIL HRRHSALCIP EAKCACTDSM GVPRALGETW NSSLSGCCQH
QCQAPDTIVP VDLGCPSPRP ESCLRFGEVA LLLPTKDPCC LGTVCVCNQT LCEGLAPTCR
PGHRLLTHFQ EDSCCPSYSC ECDPDLCEAE LVPSCRQDQI LITGRLGDSC CTSYFCACGD
CPDSIPECQE GEALTVHRNT TELCCPLYQC VCENFRCPQV QCGLGTALVE VWSPDRCCPY
KSCECDCDTI PVPRCHLWEK SQLDEEFMHS VENVCGCAKY ECVKAPVCLS RELGVMQPGQ
TVVELSADGV CHTSRCTTVL DPLTNFYQIN TTSVLCDIHC EANQEYEHPR DLAACCGSCR
NVSCLFTFPN GTTSLFLPGA SWIADCARHH CSSTPLGAVL VRSPISCPPL NETECAKVGG
SVVPSLEGCC RTCKEDGRSC KKVTIRMTIR KNECRSSTPV NLVSCDGRCP SASIYNYNIN
TYARFCKCCR EVGLQRRSVQ LFCATNATWV PYTVQEPTDC ACQWS
