OTOG_MOUSE
ID OTOG_MOUSE Reviewed; 2911 AA.
AC O55225; E9QMN3; G3UWC8; Q3TMP0;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2019, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Otogelin;
DE Flags: Precursor;
GN Name=Otog; Synonyms=Otgn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GLYCOSYLATION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Cochlea;
RX PubMed=9405633; DOI=10.1073/pnas.94.26.14450;
RA Cohen-Salmon M., El-Amraoui A., Leibovici M., Petit C.;
RT "Otogelin: a glycoprotein specific to the acellular membranes of the inner
RT ear.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:14450-14455(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:EDL22925.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=10655058; DOI=10.1038/72793;
RA Simmler M.C., Cohen-Salmon M., El-Amraoui A., Guillaud L., Benichou J.C.,
RA Petit C., Panthier J.J.;
RT "Targeted disruption of otog results in deafness and severe imbalance.";
RL Nat. Genet. 24:139-143(2000).
RN [6]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11506947; DOI=10.1016/s0378-5955(01)00312-4;
RA El-Amraoui A., Cohen-Salmon M., Petit C., Simmler M.-C.;
RT "Spatiotemporal expression of otogelin in the developing and adult mouse
RT inner ear.";
RL Hear. Res. 158:151-159(2001).
CC -!- FUNCTION: Glycoprotein specific to acellular membranes of the inner
CC ear. May be required for the anchoring of the otoconial membranes and
CC cupulae to the underlying neuroepithelia in the vestibule. May be
CC involved in the organization and/or stabilization of the fibrillar
CC network that compose the tectorial membrane in the cochlea. May play a
CC role in mechanotransduction processes. {ECO:0000269|PubMed:10655058}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000269|PubMed:11506947, ECO:0000269|PubMed:9405633}; Peripheral
CC membrane protein {ECO:0000269|PubMed:11506947,
CC ECO:0000269|PubMed:9405633}; Extracellular side
CC {ECO:0000269|PubMed:11506947, ECO:0000269|PubMed:9405633}. Secreted,
CC extracellular space {ECO:0000269|PubMed:9405633}. Note=Found in fiber-
CC like structures during the maturation process of the tectorial membrane
CC (PubMed:9405633).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O55225-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O55225-2; Sequence=VSP_029715, VSP_029716;
CC -!- TISSUE SPECIFICITY: Expressed specifically in neuroepithelial
CC supporting cells of the inner ear. Expressed in the cochlea between
CC postnatal day P0 and P6 in pseudostratified cells of the greater
CC epithelial ridge, in supporting cells of the neuroepithelium comprising
CC Deiter's, Hensen's, pillar and Claudius cells, in epithelial cells of
CC the Reissner's membrane, in a small set of cells comprising the spiral
CC prominence. Expressed in the cochlea at P15 in interdental cells
CC located underneath the limbal part of the tectorial membrane. Expressed
CC in the vestibular apparatus at P0 in supporting cells of the saccular,
CC utricular maculae and cristae ampullares, in the epithelial cells of
CC the roof of the saccule but not in the roof of the utricle and cristae
CC ampullares (at protein level). Expressed in the cochlea and vestibular
CC organ of the inner ear. {ECO:0000269|PubMed:11506947,
CC ECO:0000269|PubMed:9405633}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the epithelial cells of the otic
CC vesicle at 10 dpc. Expressed in non-sensory cells of the developing
CC vestibule, in the transitory epithelium of the saccule, utricle and
CC cristae ampullares, in epithelial cells of the roof of the saccule, but
CC not the roof of the utricle nor the cristae ampullares at 13 dpc.
CC Expressed in supporting cells of the vestibular maculae at 13 dpc
CC onward birth. Expressed in non-sensory cells of the emerging cochlear
CC duct at 12 dpc. Expressed in the pluristratified sensory epithelium as
CC well as in the epithelium of the roof at 14 dpc. Expressed in the
CC developing sensory epithelium (the spiral limbus, the greater
CC epithelial ridge and the lesser epithelial ridge) of the cochlear duct,
CC the interdental cells of the spiral limbus and in the columnar cells
CC that form the greater epithelial ridge at 16 and 17 dpc. Expressed in
CC the non-sensory pillar, Deiter's and Hensen's cells of the organ of
CC Corti and Claudius cells at 19 dpc onward birth (at protein level).
CC {ECO:0000269|PubMed:10655058, ECO:0000269|PubMed:11506947}.
CC -!- PTM: N-glycosylated. Not O-glycosylated. {ECO:0000269|PubMed:9405633}.
CC -!- DISRUPTION PHENOTYPE: Impaired vestibular and auditory functions.
CC {ECO:0000269|PubMed:10655058}.
CC -!- SIMILARITY: Belongs to the otogelin family. {ECO:0000305}.
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DR EMBL; U96411; AAB96561.1; -; mRNA.
DR EMBL; AK165831; BAE38401.1; -; mRNA.
DR EMBL; AC020786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC120135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466603; EDL22925.1; -; Genomic_DNA.
DR CCDS; CCDS52251.1; -. [O55225-1]
DR PIR; T42214; T42214.
DR RefSeq; NP_038652.2; NM_013624.2. [O55225-1]
DR SMR; O55225; -.
DR STRING; 10090.ENSMUSP00000130949; -.
DR GlyGen; O55225; 3 sites.
DR iPTMnet; O55225; -.
DR PhosphoSitePlus; O55225; -.
DR PaxDb; O55225; -.
DR PRIDE; O55225; -.
DR Antibodypedia; 77421; 8 antibodies from 2 providers.
DR DNASU; 18419; -.
DR Ensembl; ENSMUST00000164538; ENSMUSP00000130949; ENSMUSG00000009487. [O55225-1]
DR GeneID; 18419; -.
DR KEGG; mmu:18419; -.
DR UCSC; uc009gyi.1; mouse. [O55225-2]
DR UCSC; uc009gyk.2; mouse.
DR CTD; 340990; -.
DR MGI; MGI:1202064; Otog.
DR VEuPathDB; HostDB:ENSMUSG00000009487; -.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000157490; -.
DR HOGENOM; CLU_000076_0_0_1; -.
DR InParanoid; O55225; -.
DR OMA; EMFGNSW; -.
DR OrthoDB; 12226at2759; -.
DR TreeFam; TF330609; -.
DR BioGRID-ORCS; 18419; 0 hits in 72 CRISPR screens.
DR PRO; PR:O55225; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; O55225; protein.
DR Bgee; ENSMUSG00000009487; Expressed in saccule of membranous labyrinth and 16 other tissues.
DR ExpressionAtlas; O55225; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IMP:MGI.
DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR InterPro; IPR007934; AbfB_ABD.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR030105; Otogelin.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF228; PTHR11339:SF228; 1.
DR Pfam; PF05270; AbfB; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; SSF110221; 1.
DR SUPFAM; SSF57567; SSF57567; 3.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..2911
FT /note="Otogelin"
FT /evidence="ECO:0000255"
FT /id="PRO_0000312149"
FT DOMAIN 89..126
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 137..309
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 499..675
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 767..831
FT /note="TIL"
FT /evidence="ECO:0000255"
FT DOMAIN 971..1140
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 2096..2276
FT /note="VWFD 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 2826..2911
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 1456..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1683..1702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1859..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1465..1488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 800
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1465
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2060
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 93..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 101..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 115..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 139..272
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 186..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 501..639
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 523..674
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 545..553
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 973..1102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1017..1024
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2098..2235
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2826..2875
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 2840..2889
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 2851..2906
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 2855..2908
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT VAR_SEQ 652..693
FT /note="SPVGVPESTPQLFGNSWKTLSACVPLVPGSLLDPCDVHLQAA -> YVSLPC
FT DRKERETHGPLRVCIQRHCLTQTQTHTHTHTHTHTT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029715"
FT VAR_SEQ 694..2911
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029716"
FT CONFLICT 547
FT /note="L -> P (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 904
FT /note="V -> M (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 1143
FT /note="R -> G (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 1424..1427
FT /note="RVEG -> GRS (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 2006
FT /note="V -> M (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 2021
FT /note="K -> Q (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 2048
FT /note="R -> H (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 2201
FT /note="I -> M (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
FT CONFLICT 2382
FT /note="I -> V (in Ref. 1; AAB96561)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2911 AA; 313620 MW; 59A234779D0BC296 CRC64;
MGARMPRRCL LLLSCFCLLR VESTAEVQHQ ASALTWKISA ELQQEPAPEP SHTYQEMSLA
VEDVTTVMEG QEAEALAASA MSSWERRLHR AKCAPSYLFS CFNGGECVHP ALCDCRRFNA
TGPRCQLVYN VGPERDSICR TWGQHHVETF DGLYYYFSGK GSYTLVGHHE PEGQSFSIQV
HNDPQCGSAH YTCPRSVSLF LSGEREICLA KEVTHGGVRV QLPQVVGGVQ LQQLAGYVIA
RHPSAFTLAW DGISAIYIKM SPEFLGWTHG LCGNNNADPQ DDLVTSYGKV TDDVGEFVHS
WQEQVPNSPP GPVTTSLPRP PCLQQSPASM QGVYERCEVL LRPPFDTCHA YVSPLPFAAS
CTSDLCQSGG DEATWCRALM EYARACAQAG RPLQGWRTQL SQCTVHCKEK AFIYNECIAC
CPASCQSRAS CVDSEITCVD GCYCPNGLIF EDGGCMSPAE CPCEFHGTLH PPGSVVTEDC
NACTCTAGKW VCSSSVCPAE CSVTGDIHFT TFDGRRYTFP ATCQYILAKS RSSGTFTVTL
QNAPCGLNQD GACVQSVSVI LHQDPRRQVT LTQAGDVLLF DQYKITPPYS DDAFEIRRLS
SVFLRVRTNV GVRILYDREG LRLYLQVDQR WVEDTVGLCG TFNGNTQDDF LSPVGVPEST
PQLFGNSWKT LSACVPLVPG SLLDPCDVHL QAASYALQSC SVLTGELFAP CSAYLSPIPY
FEQCRRDACR CGQPCLCATL AHYARLCRRH GLPVDFRAHL PACALSCEAT KEYSPCVTLC
APTCQDLASP DVCGANGGGN FSREECVEGC TCPPDTFLDT QADLCVPRNQ CSCHFQGVDY
PPGDSDIPSL GHCHCKDGVM SCDSRAPAAA CPAGQVFVNC SELHPDPELS RERTCEQQLL
NLSVPARGPC LSGCACPQGL LRHGDACFPP EECPCTWKGK EYFPGDQVVS SCHTCVCQRG
SFQCTLHPCA STCTAYGDRH YRTFDGLPYD FVGACKVHLV KSTSELSFSV MVEDVNCYGS
GVICRKSISI NVGSSLIIFD DDSGDPSPES FLDEKQAVHI WRAGFFTLVH FPREHITLLW
DQRTTVHVQA GPQWQGQLVG LCGNFDLKTI NEMRTPENLE LTNPQEFGSS WAAVECPDTP
DPRDTCVLNP LREPFARKEC GILLSEVFET CHPVVDVTWF YSNCLTDTCG CSRGGDCECF
CASVAAYAHQ CCQHGVVIDW RTPRICPYDC DFFNKALGKG PYQLSSVAAG GTLVATKAVD
SDIALVRAED LAPGDISSFL LTAALYKAKA HDPDVVSLEA ADRPNFFLHT TANGSIGLAK
WQRDEAFHQH ASFSLHRGTW QAGLVALESL AKPGSFLHSS GLELALRAYE HTEVFRGGAL
FRLLDAKPLG AAYPTCEWRY DACASPCFQT CRDPRATSCQ DVPRVEGCVP VCPTPKVLDE
VTQRCVYLED CVEPAPRGPT ETLGNETLVP GQVPPTTSAE QQLPQGLPGA SAYSPAPVPV
APPTSAPNPP MAATEGQAPS PGSTQPTLQT PLGLTTSNFP AGHTEATARE EGAASLLTTS
HPPGFSSSLP SSLQMPTSGI VSGATETTKV TITFTGSPNT TVASRSPPIP RFPLMTKAVT
VPSHDSFPVK TTPLQPSWLW SLSSRPMTSL GATSWPPTSP GSHLSTAVTK VANKTMTSLS
VLAQSTSSSS QPLAAVTTAH RAPASPLVTK GLEVVSATEK GEAGHSQLTE LPVSPPPSPA
PIDLPHPAQH TTTAPGPSAL SPGILAAGSP STGAHRPGAT ALASLEPTRP PHLLSGLPLD
TSLPLAKVGT SAPVATPGSK GYIPTPPPQH QATTLATAMT VSPLTQSLSL TVPLMSAVEE
QAHSPSPKPP QGTGMAPDQM LGATLPSFGA SSVIAGVPPT VSAAPRKSTT QRAAILSKKV
SPPTLISDSV QGGFTELTPI VSHTVTPLAT EAEGPRAGTV PLVPTTYSLS RVSARTASRE
GPLVLLPQLA EAYGTPAGLQ PQEDLVRQAT TEQSGRSAPA KSIAEESMEA EVNTSATCVP
IAEQDCVRHI CLEGQLIRVN QTQHCPQGAV RPRCGVLGLA VRVGGDRCCP QWECACRCSI
FPDLSFVTFD GSHAALFKEA IYVLSQSPDE TISVHVLDCK SANLGHLNWP PFCLVILNVT
HLAHHVSIDR FNRKVTVDSQ VVWPPMSRYG FRIEDTGHMY IVRTPSHIQI QWLHSSGLMI
LEASKVSKTQ GHGLCGICDG DAANDLTLKD GSVLGEAEDP APFLDSWQVP SSLTSEGQTR
FRPDSCATAD CSPCLRMVSN RTFSACHSFV SPESFCELWI RDTKYVQQPC VALTVYVAMC
HKFHVCIEWR GSDYCPFLCS SDSTYQACVA ACEPPDTCQD GILGPLDPEQ CQVLGEGCVC
TEGTILHRRH SALCIPEDKC ACTDSTGVPR ALGETWNSSL SGCCQQQCQA PDTIIPVDLD
CPGPRPESCP RFGEVILLQP TEDPCCLGSV CVCNQTLCEG LAPTCRPGHS LITHFQEDSC
CPSYSCECDP GLCEAEQVPT CREDQILIEG RLGDSCCTSY FCGCGECSDP MPECQEGEAL
TVHRNTTELC CPLYQCVCEN FRCPQVQCGM GTSLVEVWSP DRCCPYKSCE CDCDTIPVPR
CHLWEKSQLD EEFMHSVENV CGCAKYECVK APVCLSRELG VMQPGQTVVE LSADGVCHTS
RCTDVLDPLT NFYQINITSV LCDMHCEANQ EYDHPRDLAA CCGSCRNVSC LFTFPNGTTS
LFLPGASWIA DCARHHCGST PLGAVLVRSP ISCPPFNETE CAKVGGSVVP SLEGCCRACK
EDGRSCKKVT IRMTIRKNDC RSNTPVNLVS CDGRCPSASI YNHNINTYAR FCKCCREVGL
QRRSVQLFCA TNATWVPYTV QEPTDCACQW S
