ID   OTOMP_DANRE             Reviewed;         371 AA.
AC   Q0VIL3; Q6DGA2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Otolith matrix protein 1;
DE            Short=OMP-1;
DE   Flags: Precursor;
GN   Name=otomp; Synonyms=omp1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kollmar R., Stevenson A., Kang Y.-J., Jiang Z.Y.;
RT   "A comparison of otolith proteins in euteleostei.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=15905077; DOI=10.1016/j.mod.2005.03.002;
RA   Murayama E., Herbomel P., Kawakami A., Takeda H., Nagasawa H.;
RT   "Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal
RT   otolith growth and their correct anchoring onto the sensory maculae.";
RL   Mech. Dev. 122:791-803(2005).
CC   -!- FUNCTION: Required for normal otolith growth and deposition of otolin-1
CC       in the otolith. {ECO:0000269|PubMed:15905077}.
CC   -!- SUBUNIT: Interacts with OTOL1. {ECO:0000250|UniProtKB:Q9IBF7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9IBF7}.
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DR   EMBL; AY681353; AAV91906.1; -; mRNA.
DR   EMBL; BC076449; AAH76449.1; -; mRNA.
DR   EMBL; BC134025; AAI34026.1; -; mRNA.
DR   RefSeq; NP_001038552.1; NM_001045087.1.
DR   AlphaFoldDB; Q0VIL3; -.
DR   SMR; Q0VIL3; -.
DR   STRING; 7955.ENSDARP00000106982; -.
DR   MEROPS; S60.976; -.
DR   PaxDb; Q0VIL3; -.
DR   Ensembl; ENSDART00000130830; ENSDARP00000106982; ENSDARG00000040306.
DR   GeneID; 565818; -.
DR   KEGG; dre:565818; -.
DR   CTD; 565818; -.
DR   ZFIN; ZDB-GENE-040709-1; otomp.
DR   eggNOG; ENOG502QUF9; Eukaryota.
DR   GeneTree; ENSGT00940000166763; -.
DR   InParanoid; Q0VIL3; -.
DR   OrthoDB; 232859at2759; -.
DR   PhylomeDB; Q0VIL3; -.
DR   PRO; PR:Q0VIL3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000040306; Expressed in dorsal plus ventral thalamus and 26 other tissues.
DR   ExpressionAtlas; Q0VIL3; baseline and differential.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0006826; P:iron ion transport; IBA:GO_Central.
DR   GO; GO:0048840; P:otolith development; IMP:ZFIN.
DR   InterPro; IPR001156; Transferrin-like_dom.
DR   Pfam; PF00405; Transferrin; 1.
DR   PRINTS; PR00422; TRANSFERRIN.
DR   SMART; SM00094; TR_FER; 1.
DR   PROSITE; PS51408; TRANSFERRIN_LIKE_4; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..371
FT                   /note="Otolith matrix protein 1"
FT                   /id="PRO_0000332930"
FT   DOMAIN          27..367
FT                   /note="Transferrin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
SQ   SEQUENCE   371 AA;  40776 MW;  7B8873161F462AE6 CRC64;
     MDLPGGHLAV VLFLFVLVSM STENNIIRWC TVSDAEDQKC LDLAGNATAR NLRGQLVCVR
     GQSPTDCMKQ IKNGTADAST MYADEIYTAG FCYGLDVAVG ESYNGVDGIN YYVVALARTS
     SSDLSLLEMH ERSSCHPGMR TTVGWTVPIG FLVNTSQISV DVQCNFPHAV GDFFGYSCVP
     GVKDPEHDPK GNNPRNLCEA CIGDENDRHI CANNPRERHF GEAGALRCVA ENLGDVAFVK
     HTTVFDNMQG KNQESWALDL ELEDLKLLCP DGSEANLFQH ESCHLAVVPT NAVVVRLEDK
     CRVYKFLERV QNAFGNTTEG FSLFSSVNYG QPDVLFSDST KKLLRVMGTY TSWLGPSYTT
     ILRAFECEGL C