ID   OTOR_LITCT              Reviewed;         133 AA.
AC   Q9I8P5;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Otoraplin;
DE   Flags: Precursor;
GN   Name=OTOR;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10873378; DOI=10.1006/geno.2000.6224;
RA   Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S.,
RA   Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C.;
RT   "A novel conserved cochlear gene, OTOR: identification, expression
RT   analysis, and chromosomal mapping.";
RL   Genomics 66:242-248(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MIA/OTOR family. {ECO:0000305}.
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DR   EMBL; AF233519; AAF82728.1; -; mRNA.
DR   AlphaFoldDB; Q9I8P5; -.
DR   SMR; Q9I8P5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR042801; OTOR.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47146; PTHR47146; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; SH3 domain; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..133
FT                   /note="Otoraplin"
FT                   /id="PRO_0000019036"
FT   DOMAIN          42..115
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DISULFID        35..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..132
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   133 AA;  15243 MW;  25440C1A3CF911AE CRC64;
     MAKTFYVVVI VLCLGFIHQK AYGVYMQKLS DKKLCADDEC IYAISFGRAE DDYNAPDCRF
     VNLKKGELVY IYTKLVKEND DAGEFWSGSV YSDQYRDQQG LVGYFPSSLV TELTVYKDEL
     QELPTTAVDF YCD