ID   OTOR_MOUSE              Reviewed;         128 AA.
AC   Q9JIE3;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Otoraplin;
DE   AltName: Full=Melanoma inhibitory activity-like protein;
DE   Flags: Precursor;
GN   Name=Otor; Synonyms=Mial;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10873378; DOI=10.1006/geno.2000.6224;
RA   Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S.,
RA   Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C.;
RT   "A novel conserved cochlear gene, OTOR: identification, expression
RT   analysis, and chromosomal mapping.";
RL   Genomics 66:242-248(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetus;
RX   PubMed=11161796; DOI=10.1006/geno.2000.6409;
RA   Rendtorff N.D., Frodin M., Attie-Bitach T., Vekemans M., Tommerup N.;
RT   "Identification and characterization of an inner ear-expressed human
RT   melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent
RT   polymorphism that abolishes translation.";
RL   Genomics 71:40-52(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in cochlea.
CC   -!- SIMILARITY: Belongs to the MIA/OTOR family. {ECO:0000305}.
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DR   EMBL; AF233333; AAF82079.1; -; mRNA.
DR   EMBL; AJ243939; CAC27444.1; -; mRNA.
DR   CCDS; CCDS16809.1; -.
DR   RefSeq; NP_065620.1; NM_020595.3.
DR   AlphaFoldDB; Q9JIE3; -.
DR   SMR; Q9JIE3; -.
DR   STRING; 10090.ENSMUSP00000028902; -.
DR   PhosphoSitePlus; Q9JIE3; -.
DR   PaxDb; Q9JIE3; -.
DR   PRIDE; Q9JIE3; -.
DR   Antibodypedia; 9190; 66 antibodies from 21 providers.
DR   DNASU; 57329; -.
DR   Ensembl; ENSMUST00000028902; ENSMUSP00000028902; ENSMUSG00000027416.
DR   GeneID; 57329; -.
DR   KEGG; mmu:57329; -.
DR   UCSC; uc008mqc.1; mouse.
DR   CTD; 56914; -.
DR   MGI; MGI:1888678; Otor.
DR   VEuPathDB; HostDB:ENSMUSG00000027416; -.
DR   eggNOG; ENOG502S18Q; Eukaryota.
DR   GeneTree; ENSGT00950000182767; -.
DR   HOGENOM; CLU_158739_0_1_1; -.
DR   InParanoid; Q9JIE3; -.
DR   OMA; LCADDDC; -.
DR   OrthoDB; 1421159at2759; -.
DR   PhylomeDB; Q9JIE3; -.
DR   TreeFam; TF332724; -.
DR   BioGRID-ORCS; 57329; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Otor; mouse.
DR   PRO; PR:Q9JIE3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q9JIE3; protein.
DR   Bgee; ENSMUSG00000027416; Expressed in vestibular epithelium and 53 other tissues.
DR   ExpressionAtlas; Q9JIE3; baseline and differential.
DR   Genevisible; Q9JIE3; MM.
DR   GO; GO:0005576; C:extracellular region; ISA:MGI.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:MGI.
DR   GO; GO:0001502; P:cartilage condensation; IMP:MGI.
DR   CDD; cd11891; MIAL; 1.
DR   InterPro; IPR042801; OTOR.
DR   InterPro; IPR035554; Otoraplin_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47146; PTHR47146; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; SH3 domain; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..128
FT                   /note="Otoraplin"
FT                   /id="PRO_0000019034"
FT   DOMAIN          39..110
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DISULFID        32..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..127
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  14328 MW;  3DD47D4C77C4A7FD CRC64;
     MARILILLLG GLVVLCAGHG VFMDKLSSKK LCADEECVYT ISLARAQEDY NAPDCRFIDV
     KKGQQIYVYS KLVTENGAGE FWAGSVYGDH QDEMGIVGYF PSNLVKEQRV YQEATKEIPT
     TDIDFFCE