ID   OTOSP_CAVPO             Reviewed;          88 AA.
AC   Q8K559;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Otospiralin;
DE   Flags: Precursor;
GN   Name=OTOS;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=11880501; DOI=10.1523/jneurosci.22-05-01718.2002;
RA   Delprat B., Boulanger A.M., Wang J., Beaudoin V., Guitton M.J., Venteo S.,
RA   Dechesne C.J., Pujol R., Lavigne-Rebillard M., Puel J.-L., Hamel C.P.;
RT   "Down regulation of otospiralin, a novel inner ear protein, causes hair
RT   cell degeneration and deafness.";
RL   J. Neurosci. 22:1718-1725(2002).
CC   -!- FUNCTION: May be essential for the survival of the neurosensory
CC       epithelium of the inner ear. {ECO:0000269|PubMed:11880501}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ear specific.
CC   -!- SIMILARITY: Belongs to the otospiralin family. {ECO:0000305}.
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DR   EMBL; AY062255; AAL47488.1; -; mRNA.
DR   RefSeq; NP_001166464.1; NM_001172993.1.
DR   AlphaFoldDB; Q8K559; -.
DR   SMR; Q8K559; -.
DR   STRING; 10141.ENSCPOP00000020041; -.
DR   GeneID; 100135590; -.
DR   KEGG; cpoc:100135590; -.
DR   CTD; 150677; -.
DR   eggNOG; ENOG502S3R4; Eukaryota.
DR   HOGENOM; CLU_170470_0_0_1; -.
DR   InParanoid; Q8K559; -.
DR   OMA; FHVPYQQ; -.
DR   OrthoDB; 1540402at2759; -.
DR   TreeFam; TF336889; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR028224; Otospiralin.
DR   PANTHER; PTHR35073; PTHR35073; 1.
DR   Pfam; PF15182; OTOS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..88
FT                   /note="Otospiralin"
FT                   /id="PRO_0000021975"
SQ   SEQUENCE   88 AA;  10025 MW;  4EBED7D46C50AC74 CRC64;
     MQACMVPGLA LCLLLGSLTE AKPLQEYDPY AEPPAMPYWP FSTSDFWNYI QYLQTQGAYP
     QVEDLARTFF AHFPLGSTLG FHVPYQED