ID   OTOSP_MOUSE             Reviewed;          89 AA.
AC   Q8R448;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Otospiralin;
DE   AltName: Full=Organ of Corti 10 kDa protein;
DE   Flags: Precursor;
GN   Name=Otos; Synonyms=Ocp10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   PubMed=11880501; DOI=10.1523/jneurosci.22-05-01718.2002;
RA   Delprat B., Boulanger A.M., Wang J., Beaudoin V., Guitton M.J., Venteo S.,
RA   Dechesne C.J., Pujol R., Lavigne-Rebillard M., Puel J.-L., Hamel C.P.;
RT   "Down regulation of otospiralin, a novel inner ear protein, causes hair
RT   cell degeneration and deafness.";
RL   J. Neurosci. 22:1718-1725(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Organ of Corti;
RX   PubMed=15177554; DOI=10.1016/j.ygeno.2004.01.005;
RA   Pompeia C., Hurle B., Belyantseva I.A., Noben-Trauth K., Beisel K., Gao J.,
RA   Buchoff P., Wistow G., Kachar B.;
RT   "Gene expression profile of the mouse organ of Corti at the onset of
RT   hearing.";
RL   Genomics 83:1000-1011(2004).
CC   -!- FUNCTION: May be essential for the survival of the neurosensory
CC       epithelium of the inner ear. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ear specific.
CC   -!- SIMILARITY: Belongs to the otospiralin family. {ECO:0000305}.
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DR   EMBL; AY062257; AAL47490.1; -; Genomic_DNA.
DR   EMBL; AY078071; AAL85926.1; -; mRNA.
DR   CCDS; CCDS35668.1; -.
DR   RefSeq; NP_694754.1; NM_153114.2.
DR   RefSeq; XP_017176304.1; XM_017320815.1.
DR   RefSeq; XP_017176307.1; XM_017320818.1.
DR   AlphaFoldDB; Q8R448; -.
DR   STRING; 10090.ENSMUSP00000061683; -.
DR   PaxDb; Q8R448; -.
DR   PRIDE; Q8R448; -.
DR   Antibodypedia; 47715; 40 antibodies from 12 providers.
DR   Ensembl; ENSMUST00000053144; ENSMUSP00000061683; ENSMUSG00000044055.
DR   GeneID; 260301; -.
DR   KEGG; mmu:260301; -.
DR   UCSC; uc007cbr.1; mouse.
DR   CTD; 150677; -.
DR   MGI; MGI:2672814; Otos.
DR   VEuPathDB; HostDB:ENSMUSG00000044055; -.
DR   eggNOG; ENOG502S3R4; Eukaryota.
DR   GeneTree; ENSGT00390000011600; -.
DR   HOGENOM; CLU_170470_0_0_1; -.
DR   InParanoid; Q8R448; -.
DR   OMA; FHVPYQQ; -.
DR   OrthoDB; 1540402at2759; -.
DR   PhylomeDB; Q8R448; -.
DR   TreeFam; TF336889; -.
DR   BioGRID-ORCS; 260301; 5 hits in 72 CRISPR screens.
DR   ChiTaRS; Otos; mouse.
DR   PRO; PR:Q8R448; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q8R448; protein.
DR   Bgee; ENSMUSG00000044055; Expressed in vestibular membrane of cochlear duct and 28 other tissues.
DR   ExpressionAtlas; Q8R448; baseline and differential.
DR   Genevisible; Q8R448; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR   InterPro; IPR028224; Otospiralin.
DR   PANTHER; PTHR35073; PTHR35073; 1.
DR   Pfam; PF15182; OTOS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..89
FT                   /note="Otospiralin"
FT                   /id="PRO_0000021977"
SQ   SEQUENCE   89 AA;  10185 MW;  BCA37082BD0931B8 CRC64;
     MQACVLWWLA LGMLLGIPAG AKPMPEEADP HTQPPAMPYW PFSTSDFWNY VQYFQTQGAY
     PQIEDMARTF FAHFPLGSTL GFHVPYQED