ID   OTOSP_RAT               Reviewed;          89 AA.
AC   Q8K560;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Otospiralin;
DE   Flags: Precursor;
GN   Name=Otos;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Wistar;
RX   PubMed=11880501; DOI=10.1523/jneurosci.22-05-01718.2002;
RA   Delprat B., Boulanger A.M., Wang J., Beaudoin V., Guitton M.J., Venteo S.,
RA   Dechesne C.J., Pujol R., Lavigne-Rebillard M., Puel J.-L., Hamel C.P.;
RT   "Down regulation of otospiralin, a novel inner ear protein, causes hair
RT   cell degeneration and deafness.";
RL   J. Neurosci. 22:1718-1725(2002).
CC   -!- FUNCTION: May be essential for the survival of the neurosensory
CC       epithelium of the inner ear. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ear specific. Expressed in the cochlea and
CC       vestibule, but not in the cochlear nerve, cochlear nucleus, spinal
CC       chord, muscle, cerebral cortex, cerebellum, diencephalon and olfactory
CC       bulb. In the cochlea, expressed in fibrocytes of the spiral limbus,
CC       spiral ligament and suprastrial zone. In the vestibule, expressed in
CC       cells located to the stroma below the macular and crista sensory
CC       epithelia and in the subepithelial layer of the walls of semicircular
CC       canals and maculae. {ECO:0000269|PubMed:11880501}.
CC   -!- SIMILARITY: Belongs to the otospiralin family. {ECO:0000305}.
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DR   EMBL; AY062254; AAL47487.1; -; mRNA.
DR   RefSeq; NP_631927.1; NM_139188.3.
DR   RefSeq; XP_008765580.1; XM_008767358.2.
DR   RefSeq; XP_017451757.1; XM_017596268.1.
DR   RefSeq; XP_017451758.1; XM_017596269.1.
DR   AlphaFoldDB; Q8K560; -.
DR   STRING; 10116.ENSRNOP00000022220; -.
DR   PaxDb; Q8K560; -.
DR   Ensembl; ENSRNOT00000022220; ENSRNOP00000022220; ENSRNOG00000016567.
DR   GeneID; 246044; -.
DR   KEGG; rno:246044; -.
DR   CTD; 150677; -.
DR   RGD; 708465; Otos.
DR   eggNOG; ENOG502S3R4; Eukaryota.
DR   GeneTree; ENSGT00390000011600; -.
DR   InParanoid; Q8K560; -.
DR   OMA; FHVPYQQ; -.
DR   OrthoDB; 1540402at2759; -.
DR   PhylomeDB; Q8K560; -.
DR   TreeFam; TF336889; -.
DR   PRO; PR:Q8K560; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000016567; Expressed in spleen and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:RGD.
DR   InterPro; IPR028224; Otospiralin.
DR   PANTHER; PTHR35073; PTHR35073; 1.
DR   Pfam; PF15182; OTOS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..89
FT                   /note="Otospiralin"
FT                   /id="PRO_0000021978"
SQ   SEQUENCE   89 AA;  10095 MW;  C61F64E1AF795EC9 CRC64;
     MQPCVLWWLA LGLLLGIPAG AKPTPEEADP NAQPPAMPYW PFSTSDFWNY VQYFQSQGAY
     PQIEDMARTF FAHFPLGSTL GFHVPYQED