ID   OTP_HELTB               Reviewed;         363 AA.
AC   Q6SR68;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Homeobox protein orthopedia;
GN   Name=Otp;
OS   Heliocidaris tuberculata (Sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC   Heliocidaris.
OX   NCBI_TaxID=7635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=14984035; DOI=10.1002/jez.b.46;
RA   Zhou N., Wilson K.A., Andrews M.E., Kauffman J.S., Raff R.A.;
RT   "Evolution of OTP-independent larval skeleton patterning in the direct-
RT   developing sea urchin, Heliocidaris erythrogramma.";
RL   J. Exp. Zool. B Mol. Dev. Evol. 300:58-71(2003).
CC   -!- FUNCTION: Involved in larval skeletal patterning.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at the late gastrula stage, in 2 cells
CC       of the oral ectoderm. {ECO:0000269|PubMed:14984035}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY452140; AAS00592.1; -; mRNA.
DR   AlphaFoldDB; Q6SR68; -.
DR   SMR; Q6SR68; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Homeobox protein orthopedia"
FT                   /id="PRO_0000292435"
FT   DNA_BIND        114..173
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          48..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           342..355
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        48..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  38037 MW;  11B4F3AE0A8B1A0D CRC64;
     MERTLAHVPS MELSTEALLV TGGLDNTNKM ITSSAVRNDD GTMISQHSEK VSYGTSGAPD
     GSTPPVTAAG GGSEGNGIGG GGGGGGGGGM VGDGTGHSVG SSGSGNDDDK PAKQKRHRTR
     FTPAQLNELE RNFAKTHYPD IFMREEIAMR VGLTESRVQV WFQNRRAKWK KRKKTTNVFR
     TPGALLPSHG LAQFPSPMND SFCNFHGQDT RGWPAMSGMT THMAPHMTTH MPSHQMSQMG
     GGPGSALALP PSLPRQGLGQ TMQQQSVNCS MGQTTGLNTL SMGTNGSMGS MTSMYQPSLG
     GMTTGSMSSG LSSPSPPNLP VTDSSTDLSC SVSDAGDMWR GTSIASLRRK ALEHAASLNG
     IFR