ID   OTP_LYTVA               Reviewed;         360 AA.
AC   Q6SZ65;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Homeobox protein orthopedia;
GN   Name=Otp;
OS   Lytechinus variegatus (Green sea urchin) (Echinus variegatus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7654;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bradham C.A., Miranda E.L., McClay D.R.;
RT   "The pathway p38 MAPK-Goosecoid-Orthopedia is required for axis
RT   specification in the sea urchin embryo.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY445031; AAR17090.1; -; mRNA.
DR   AlphaFoldDB; Q6SZ65; -.
DR   SMR; Q6SZ65; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..360
FT                   /note="Homeobox protein orthopedia"
FT                   /id="PRO_0000292436"
FT   DNA_BIND        112..171
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          48..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           340..353
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        48..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  37733 MW;  35B265463F731BE8 CRC64;
     MERTLAHVPS MELSTEALLV TGGLDNTNKM ITSSAVRNDD GTMISQHSEK VSYGTSGAPD
     GSTPPVTAAG GGSEGNGIGG GGGGGGGMVG DGTGHSVGSS ASGNDDDKPA KQKRHRTRFT
     PAQLNELERN FAKTHYPDIF MREEIAMRVG LTESRVQVWF QNRRAKWKKR KKTTNVFRTP
     GALLPSHGLA QFPSPMNDSF CNFHGQDTRG WPAMSGMTTH MAPHMTTHMP SHQMSQMGGG
     PGSALALPPS IPRQGLGQSM QQQTVNCTMG QSTGLNTLSM GTNGSMGSMT SMYQPSLGGM
     TTGSMSSGLS SPSPPNLPVS DSSTDLSCSV SDAGDMWRGT SIASLRRKAL EHAASLNGNL