ID   OTP_PARLI               Reviewed;         364 AA.
AC   O76971;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Homeobox protein orthopedia;
DE   AltName: Full=Orthopedia-related;
DE   AltName: Full=PlOtp;
GN   Name=OTP;
OS   Paracentrotus lividus (Common sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX   NCBI_TaxID=7656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   FUNCTION.
RX   PubMed=10207142; DOI=10.1242/dev.126.10.2171;
RA   Di Bernardo M., Castagnetti S., Bellomonte D., Oliveri P., Melfi R.,
RA   Palla F., Spinelli G.;
RT   "Spatially restricted expression of PlOtp, a Paracentrotus lividus
RT   orthopedia-related homeobox gene, is correlated with oral ectodermal
RT   patterning and skeletal morphogenesis in late-cleavage sea urchin
RT   embryos.";
RL   Development 126:2171-2179(1999).
RN   [2]
RP   FUNCTION.
RX   PubMed=14512022; DOI=10.1016/s0012-1606(03)00317-8;
RA   Cavalieri V., Spinelli G., Di Bernardo M.;
RT   "Impairing Otp homeodomain function in oral ectoderm cells affects
RT   skeletogenesis in sea urchin embryos.";
RL   Dev. Biol. 262:107-118(2003).
CC   -!- FUNCTION: Involved in larval skeletal patterning.
CC       {ECO:0000269|PubMed:10207142, ECO:0000269|PubMed:14512022}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: Expressed at low levels in lantern and tubefeet.
CC       {ECO:0000269|PubMed:10207142}.
CC   -!- DEVELOPMENTAL STAGE: Expression starts at the gastrula stage, increases
CC       at the prism stage and peaks at the puteus larva stage. Expression is
CC       restricted to the oral epithelium. {ECO:0000269|PubMed:10207142}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ007501; CAA07543.1; -; mRNA.
DR   AlphaFoldDB; O76971; -.
DR   SMR; O76971; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..364
FT                   /note="Homeobox protein orthopedia"
FT                   /id="PRO_0000049205"
FT   DNA_BIND        116..175
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          35..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           344..357
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        35..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  38133 MW;  86658CCDD4D17E64 CRC64;
     MERTLAHVPS MELSTEALLV TGGLDNTNKM ISSSAVRNDD GTMISQHSDK VSYGTSGAPD
     GSTPPYPAGG VGEGNGIVGG GGGGGGGGGG GMVGDGTGHS VGSSGSGNDD DKPAKQKRHR
     TRFTPAQLNE LERNFAKTHY PDIFMREEIA MRVGLTESRV QVWFQNRRAK WKKRKKTTNV
     FRTPGALLPS HGLAQFPSPM NDSFCNFHGQ DTRGWPAMSG MTTHMAPHMT THMPSHQMPL
     MGGGPGSALA LPPSLPRQGL GQSMQQQSVN CSMGQTTGLN TLSMGTNGSM GSMTSMYQPS
     LGGMTTGSMS SGLSSPSPPN LPVTDSSTDL SCSVSDAGDM WRGTSIASLR RKLEHAASLN
     GIFR