ID   OTP_SACKO               Reviewed;         322 AA.
AC   Q7YTC2;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Homeobox protein orthopedia;
GN   Name=otp;
OS   Saccoglossus kowalevskii (Acorn worm).
OC   Eukaryota; Metazoa; Hemichordata; Enteropneusta; Harrimaniidae;
OC   Saccoglossus.
OX   NCBI_TaxID=10224;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=12837244; DOI=10.1016/s0092-8674(03)00469-0;
RA   Lowe C.J., Wu M., Salic A., Evans L., Lander E., Stange-Thomann N.,
RA   Gruber C.E., Gerhart J., Kirschner M.;
RT   "Anteroposterior patterning in hemichordates and the origins of the
RT   chordate nervous system.";
RL   Cell 113:853-865(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- DEVELOPMENTAL STAGE: Expression is restricted to prosome, mesosome and
CC       anterior metasome. {ECO:0000269|PubMed:12837244}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY313152; AAP79292.1; -; mRNA.
DR   RefSeq; NP_001158374.1; NM_001164902.1.
DR   AlphaFoldDB; Q7YTC2; -.
DR   SMR; Q7YTC2; -.
DR   GeneID; 100303481; -.
DR   KEGG; sko:100303481; -.
DR   CTD; 23440; -.
DR   OrthoDB; 1243020at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..322
FT                   /note="Homeobox protein orthopedia"
FT                   /id="PRO_0000292437"
FT   DNA_BIND        90..149
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          41..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           301..314
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        53..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  34843 MW;  CE8485F35FAD926C CRC64;
     MEAASLHVQM HTASDPFLSH AALNNNNTMN KLNSAVLSQG VKDEHDNNDK LSLDSDGTTL
     LKDTSSGHGG NDGSHMGCNQ ESNDDKPLKQ KRHRTRFTPA QLNELERNFA KTHYPDIFMR
     EEIAMRVGLT ESRVQVWFQN RRAKWKKRKK QTNVFRTPGA LMPSHGLPQF PSSMGDSLCS
     FHTNDTRWPP MPAQMTSGPP LTLPPTLPRQ HTGIGQSLSG HQGGGGGMNQ SPNGFGSGIS
     VTSNGSVQPS MYQSFGGGMS SMSSMSSVST SSGLPSSPTN VTVNSPMSCS SPDTGDMWRG
     TSIAQLRRKA LEHSVTLNGG FR