ASCL3_MOUSE
ID ASCL3_MOUSE Reviewed; 174 AA.
AC Q9JJR7; Q3SXE3;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Achaete-scute homolog 3;
DE Short=ASH-3;
DE Short=mASH-3;
DE Short=mASH3;
DE AltName: Full=bHLH transcriptional regulator Sgn-1;
GN Name=Ascl3; Synonyms=Mash3, Sgn1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kemp P.R., Cooper W.N., Metcalfe J.C.;
RT "MASH3 a novel basic helix-loop-helix protein that inhibits myogenesis in
RT C2C12 cells.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=11784080; DOI=10.1006/dbio.2001.0473;
RA Yoshida S., Ohbo K., Takakura A., Takebayashi H., Okada T., Abe K.,
RA Nabeshima Y.;
RT "Sgn1, a basic helix-loop-helix transcription factor delineates the
RT salivary gland duct cell lineage in mice.";
RL Dev. Biol. 240:517-530(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11528127; DOI=10.1159/000056999;
RA Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A.,
RA Zabel B., Hankeln T., Schmidt E.R.;
RT "Comparative genomic sequencing reveals a strikingly similar architecture
RT of a conserved syntenic region on human chromosome 11p15.3 (including gene
RT ST5) and mouse chromosome 7.";
RL Cytogenet. Cell Genet. 93:284-290(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional repressor. Inhibits myogenesis.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the salivary duct cells.
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DR EMBL; AJ277605; CAC37689.1; -; mRNA.
DR EMBL; AB046448; BAB83911.1; -; mRNA.
DR EMBL; AJ400878; CAB92296.1; -; Genomic_DNA.
DR EMBL; BC104346; AAI04347.1; -; mRNA.
DR EMBL; BC104347; AAI04348.1; -; mRNA.
DR CCDS; CCDS21737.1; -.
DR RefSeq; NP_064435.1; NM_020051.1.
DR AlphaFoldDB; Q9JJR7; -.
DR SMR; Q9JJR7; -.
DR BioGRID; 208173; 5.
DR STRING; 10090.ENSMUSP00000037702; -.
DR PhosphoSitePlus; Q9JJR7; -.
DR PaxDb; Q9JJR7; -.
DR PRIDE; Q9JJR7; -.
DR Antibodypedia; 24178; 90 antibodies from 24 providers.
DR DNASU; 56787; -.
DR Ensembl; ENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951.
DR GeneID; 56787; -.
DR KEGG; mmu:56787; -.
DR UCSC; uc009jeb.1; mouse.
DR CTD; 56676; -.
DR MGI; MGI:1928820; Ascl3.
DR VEuPathDB; HostDB:ENSMUSG00000035951; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00940000162850; -.
DR HOGENOM; CLU_128274_0_0_1; -.
DR InParanoid; Q9JJR7; -.
DR OMA; DPIFRIV; -.
DR OrthoDB; 1545499at2759; -.
DR PhylomeDB; Q9JJR7; -.
DR TreeFam; TF322889; -.
DR BioGRID-ORCS; 56787; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Gps1; mouse.
DR PRO; PR:Q9JJR7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JJR7; protein.
DR Bgee; ENSMUSG00000035951; Expressed in olfactory epithelium and 23 other tissues.
DR Genevisible; Q9JJR7; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IPI:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR015660; MASH1/Ascl1a-like.
DR PANTHER; PTHR13935; PTHR13935; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..174
FT /note="Achaete-scute homolog 3"
FT /id="PRO_0000127134"
FT DOMAIN 92..144
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 153..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 174 AA; 20245 MW; D89E56C8A9D3440B CRC64;
MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD ELPLLPFSSD
TLIMNNYGDP YPFPFPMPYT NYRRCDYTYG PAFIRKRNER ERQRVKCVNE GYARLRRHLP
EDYLEKRLSK VETLRAAIKY ISYLQSLLYP DESETKKNPR TASCGSLDPA LRVI
