ASCL5_HUMAN
ID ASCL5_HUMAN Reviewed; 278 AA.
AC Q7RTU5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Achaete-scute homolog 5;
DE Short=ASH-5;
DE Short=hASH5;
DE AltName: Full=Class A basic helix-loop-helix protein 47;
DE Short=bHLHa47;
GN Name=ASCL5; Synonyms=BHLHA47;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP IDENTIFICATION.
RX PubMed=14516699; DOI=10.1016/s0925-4773(03)00130-8;
RA McLellan A.S., Langlands K., Kealey T.;
RT "Exhaustive identification of human class II basic helix-loop-helix
RT proteins by virtual library screening.";
RL Mech. Dev. 119:S285-S291(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA00301.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL139159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK000139; DAA00301.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q7RTU5; -.
DR SMR; Q7RTU5; -.
DR IntAct; Q7RTU5; 2.
DR STRING; 9606.ENSP00000472681; -.
DR PhosphoSitePlus; Q7RTU5; -.
DR BioMuta; ASCL5; -.
DR DMDM; 166988402; -.
DR PaxDb; Q7RTU5; -.
DR PeptideAtlas; Q7RTU5; -.
DR PRIDE; Q7RTU5; -.
DR UCSC; uc031prl.1; human.
DR GeneCards; ASCL5; -.
DR HGNC; HGNC:33169; ASCL5.
DR HPA; ENSG00000232237; Tissue enhanced (pancreas).
DR neXtProt; NX_Q7RTU5; -.
DR VEuPathDB; HostDB:ENSG00000232237; -.
DR eggNOG; KOG4029; Eukaryota.
DR InParanoid; Q7RTU5; -.
DR PhylomeDB; Q7RTU5; -.
DR PathwayCommons; Q7RTU5; -.
DR SignaLink; Q7RTU5; -.
DR Pharos; Q7RTU5; Tdark.
DR PRO; PR:Q7RTU5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7RTU5; protein.
DR Bgee; ENSG00000232237; Expressed in body of pancreas and 59 other tissues.
DR ExpressionAtlas; Q7RTU5; baseline and differential.
DR Genevisible; Q7RTU5; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR015660; MASH1/Ascl1a-like.
DR PANTHER; PTHR13935; PTHR13935; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..278
FT /note="Achaete-scute homolog 5"
FT /id="PRO_0000317298"
FT DOMAIN 155..207
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..242
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 278 AA; 29462 MW; 96DC775BDA61C176 CRC64;
MPMGAAERGA GPQSSAAPWA GSEKAAKRGP SKSWYPRAAA SDVTCPTGGD GADPKPGPFG
GGLALGPAPR GTMNNNFCRA LVDRRPLGPP SCMQLGVMPP PRQAPLPPAE PLGNVPFLLY
PGPAEPPYYD AYAGVFPYVP FPGAFGVYEY PFEPAFIQKR NERERQRVKC VNEGYARLRG
HLPGALAEKR LSKVETLRAA IRYIKYLQEL LSSAPDGSTP PASRGLPGTG PCPAPPATPR
PDRPGDGEAR APSSLVPESS ESSCFSPSPF LESEESWH
