ID   OTU2_YEAST              Reviewed;         307 AA.
AC   P38747; D3DKQ0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=OTU domain-containing protein 2;
GN   Name=OTU2; OrderedLocusNames=YHL013C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; U11582; AAB65066.1; -; Genomic_DNA.
DR   EMBL; AY692608; AAT92627.1; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06673.1; -; Genomic_DNA.
DR   PIR; S46827; S46827.
DR   RefSeq; NP_011850.1; NM_001179093.1.
DR   AlphaFoldDB; P38747; -.
DR   SMR; P38747; -.
DR   BioGRID; 36410; 119.
DR   IntAct; P38747; 1.
DR   STRING; 4932.YHL013C; -.
DR   MEROPS; C85.008; -.
DR   iPTMnet; P38747; -.
DR   MaxQB; P38747; -.
DR   PaxDb; P38747; -.
DR   PRIDE; P38747; -.
DR   EnsemblFungi; YHL013C_mRNA; YHL013C; YHL013C.
DR   GeneID; 856373; -.
DR   KEGG; sce:YHL013C; -.
DR   SGD; S000001005; OTU2.
DR   VEuPathDB; FungiDB:YHL013C; -.
DR   eggNOG; KOG2606; Eukaryota.
DR   GeneTree; ENSGT00940000166759; -.
DR   HOGENOM; CLU_034963_2_0_1; -.
DR   InParanoid; P38747; -.
DR   OMA; TYHRHMY; -.
DR   BioCyc; YEAST:G3O-31033-MON; -.
DR   PRO; PR:P38747; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38747; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR   GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF02338; OTU; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50802; OTU; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..307
FT                   /note="OTU domain-containing protein 2"
FT                   /id="PRO_0000202883"
FT   DOMAIN          167..307
FT                   /note="OTU"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00139"
FT   REGION          23..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..115
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  36113 MW;  5580BF0459B78395 CRC64;
     MTGMESGENL ENMEDILARH RKENKDLQNK ITGMKKQATK SKRKEVNSKC LDLQDKLKTK
     QENEIRDWKI ANNEVFDAEQ EDEVTPEKLL EQLSISRDEK EQQNVPVQQQ QQGQTKKRRN
     RQKERLAKRD AAIAKMKEEA ALEASKQPDL KKMEQESIDQ LCELKKLKQF DIQPDGHCLF
     ASILDQLKLR HDPKKLDQDM DVMKLRWLSC NYVQEHRDDF IPYLFDEETM KMKDIDEYTK
     EMEHTAQWGG EIEILALSHV FDCPISILMS GRPIQVYNEC GKNPELKLVY YKHSYALGEH
     YNSLHDS