OTX1A_DANRE
ID OTX1A_DANRE Reviewed; 338 AA.
AC Q90267; B8A5Y6;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Homeobox protein OTX1 A;
DE AltName: Full=Orthodenticle homolog 1-like;
DE AltName: Full=zOtx3;
GN Name=otx1a; Synonyms=otx1l, otx3; ORFNames=si:dkeyp-123h10.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=AB;
RX PubMed=7898305; DOI=10.1016/0169-328x(94)90004-3;
RA Mori H., Miyazaki Y., Morita T., Nitta H., Mishina M.;
RT "Different spatio-temporal expressions of three otx homeoprotein
RT transcripts during zebrafish embryogenesis.";
RL Brain Res. Mol. Brain Res. 27:221-231(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-338, AND TISSUE SPECIFICITY.
RX PubMed=8619954;
RA Mercier P., Simeone A., Cotelli F., Boncinelli E.;
RT "Expression pattern of two otx genes suggests a role in specifying anterior
RT body structures in zebrafish.";
RL Int. J. Dev. Biol. 39:559-573(1995).
RN [5]
RP FUNCTION.
RX PubMed=16611693; DOI=10.1242/dev.02352;
RA Foucher I., Mione M., Simeone A., Acampora D., Bally-Cuif L., Houart C.;
RT "Differentiation of cerebellar cell identities in absence of Fgf signalling
RT in zebrafish Otx morphants.";
RL Development 133:1891-1900(2006).
RN [6]
RP FUNCTION.
RX PubMed=17670791; DOI=10.1242/dev.001461;
RA Scholpp S., Foucher I., Staudt N., Peukert D., Lumsden A., Houart C.;
RT "Otx1l, Otx2 and Irx1b establish and position the ZLI in the
RT diencephalon.";
RL Development 134:3167-3176(2007).
CC -!- FUNCTION: Plays a role in very early embryogenesis, gastrulation, and
CC the development and subdivision of the diencephalon and the midbrain.
CC Establishes and positions the zona limitans intrathalamica (ZLI) in the
CC diencephalon. May play a role in the organizer function. Probably acts
CC redundantly with otx2 in early brain development.
CC {ECO:0000269|PubMed:16611693, ECO:0000269|PubMed:17670791}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Embryonic expression is highly dynamic. Detected
CC along the marginal zone of symmetric embryos at 5 hours of development
CC and found at the shield, a primary morphological asymmetry at 6 hours
CC of development. With the extension of the body axis, expression extends
CC to neuroectodermal regions fated to become fore- and mid-brain; found
CC in two stripes at the posterior side of the eye rudiments at 12 hours
CC of development, distributed in the diencephalon, midbrain and the
CC epiphysis at 18 hours of development, and found in the diencephalon and
CC the midbrain at 24 hours of development. {ECO:0000269|PubMed:7898305,
CC ECO:0000269|PubMed:8619954}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; D26174; BAA05160.1; -; mRNA.
DR EMBL; BC076432; AAH76432.1; -; mRNA.
DR EMBL; BX855617; CAX13497.1; -; Genomic_DNA.
DR RefSeq; NP_571290.1; NM_131215.3.
DR RefSeq; XP_009292547.1; XM_009294272.2.
DR AlphaFoldDB; Q90267; -.
DR SMR; Q90267; -.
DR STRING; 7955.ENSDARP00000013327; -.
DR PaxDb; Q90267; -.
DR Ensembl; ENSDART00000006538; ENSDARP00000013327; ENSDARG00000030703.
DR GeneID; 30462; -.
DR KEGG; dre:30462; -.
DR CTD; 30462; -.
DR ZFIN; ZDB-GENE-980526-27; otx2a.
DR eggNOG; KOG2251; Eukaryota.
DR GeneTree; ENSGT00940000167432; -.
DR HOGENOM; CLU_064370_0_0_1; -.
DR InParanoid; Q90267; -.
DR OMA; YFSGVEC; -.
DR OrthoDB; 1481439at2759; -.
DR PhylomeDB; Q90267; -.
DR TreeFam; TF351179; -.
DR PRO; PR:Q90267; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 1.
DR Bgee; ENSDARG00000030703; Expressed in spinal cord neural plate and 35 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0021549; P:cerebellum development; IGI:ZFIN.
DR GO; GO:0030902; P:hindbrain development; IGI:ZFIN.
DR GO; GO:0030901; P:midbrain development; IGI:ZFIN.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0003406; P:retinal pigment epithelium development; IGI:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..338
FT /note="Homeobox protein OTX1 A"
FT /id="PRO_0000049215"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 91..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..188
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 36145 MW; ACFA6C2A43A69014 CRC64;
MMSYLKQAPY AMNGLGLGGA TMDLLHPSVG YPTNPRKQRR ERTTFTRTQL DILESLFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQS STNSKIRPAK KKPSPSRESP
GSESSGHFTP PAVSSSSSSS SSSSGSNPSA LSGVGLISSS SSGTPVPSIW SPAPVSPVPA
PPSLPDISPP ASASCMQRAM SSGGGTTGVP SYPMPYNQAP SYAQGYPTSN AASYFGGMDC
GSYLAPMTGH AHHHPHAHHS QLSTAAAVSG HHHPHHIGQS SGHHPHHQGY GGTALPFSSS
DCLDYKEQVA SSWKLNFSSA AADCLDYKDQ AAWRFQVL
