OTX1B_DANRE
ID OTX1B_DANRE Reviewed; 323 AA.
AC Q91994; Q7ZU54;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Homeobox protein OTX1 B;
DE Short=zOtx1;
DE AltName: Full=Orthodenticle homolog 1 B;
GN Name=otx1b; Synonyms=otx1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=AB;
RX PubMed=7898305; DOI=10.1016/0169-328x(94)90004-3;
RA Mori H., Miyazaki Y., Morita T., Nitta H., Mishina M.;
RT "Different spatio-temporal expressions of three otx homeoprotein
RT transcripts during zebrafish embryogenesis.";
RL Brain Res. Mol. Brain Res. 27:221-231(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=7893604; DOI=10.1016/0925-4773(94)90062-0;
RA Li Y., Allende M.L., Finkelstein R., Weinberg E.S.;
RT "Expression of two zebrafish orthodenticle-related genes in the embryonic
RT brain.";
RL Mech. Dev. 48:229-244(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-323, AND TISSUE SPECIFICITY.
RX PubMed=8619954;
RA Mercier P., Simeone A., Cotelli F., Boncinelli E.;
RT "Expression pattern of two otx genes suggests a role in specifying anterior
RT body structures in zebrafish.";
RL Int. J. Dev. Biol. 39:559-573(1995).
CC -!- FUNCTION: May play a role in very early embryogenesis, gastrulation,
CC and the development and subdivision of the diencephalon and the
CC midbrain.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Embryonic expression is highly dynamic. In early
CC gastrula embryos, expressed in the involuting presumptive anterior
CC mesoderm. Found in the head rudiment at 9 hours of development, and at
CC 12 hours of development expression increases at the caudal side but
CC decreases at the rostral side. With the extension of the body axis,
CC expression extends to neuroectodermal regions fated to become fore- and
CC mid-brain; detected in the presumptive border between the midbrain and
CC the hindbrain at 18 hours of development, and found in the diencephalon
CC and the midbrain at 24 hours of development.
CC {ECO:0000269|PubMed:7893604, ECO:0000269|PubMed:7898305,
CC ECO:0000269|PubMed:8619954}.
CC -!- DEVELOPMENTAL STAGE: Found in embryos at 0-2 hours of development,
CC levels decrease drastically at 6 hours of development but increase
CC again at 12 hours of development. {ECO:0000269|PubMed:7893604}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; D26172; BAA05158.1; -; mRNA.
DR EMBL; U14591; AAA78900.1; -; mRNA.
DR EMBL; BC045290; AAH45290.1; -; mRNA.
DR PIR; I51751; I51751.
DR RefSeq; NP_571325.2; NM_131250.2.
DR AlphaFoldDB; Q91994; -.
DR SMR; Q91994; -.
DR STRING; 7955.ENSDARP00000064082; -.
DR PaxDb; Q91994; -.
DR PRIDE; Q91994; -.
DR Ensembl; ENSDART00000064083; ENSDARP00000064082; ENSDARG00000094992.
DR Ensembl; ENSDART00000179858; ENSDARP00000157164; ENSDARG00000094992.
DR GeneID; 30500; -.
DR KEGG; dre:30500; -.
DR CTD; 5013; -.
DR ZFIN; ZDB-GENE-980526-400; otx1.
DR eggNOG; KOG2251; Eukaryota.
DR GeneTree; ENSGT00940000161234; -.
DR HOGENOM; CLU_064370_0_0_1; -.
DR InParanoid; Q91994; -.
DR OMA; PTMDLLH; -.
DR OrthoDB; 1481439at2759; -.
DR PhylomeDB; Q91994; -.
DR TreeFam; TF351179; -.
DR PRO; PR:Q91994; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000094992; Expressed in cleaving embryo and 80 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:ZFIN.
DR GO; GO:0060875; P:lateral semicircular canal development; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0003406; P:retinal pigment epithelium development; IGI:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003026; Otx1_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01256; OTX1HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..323
FT /note="Homeobox protein OTX1 B"
FT /id="PRO_0000049213"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 91..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 151
FT /note="S -> C (in Ref. 3; AAH45290)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 35208 MW; 19425671E6D31F10 CRC64;
MMSYLKQPPY AMNGLGLSGA AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DILEALFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG SSTKTRPAKK KSSPTRESTG
SESSGQFTPP AVSSAGSSSS SSSSTNNTGI SSTSTSISTV SSIWSPAISP GSAPPSVSLP
EPVAPSNTSC MQRSVSGTAS STYPMPYNQT TGYSQGYPTP SGSYFSGVDC GSYLAPMHSH
HHPHQLSPMT ASSMPTHPHH HISQSSGHHH HHHHQAYSGT GLAFNSSDCL DYKEQTASSW
KLNFNTTDCL DYKDQASWRF QVL
