OTX1_HUMAN
ID OTX1_HUMAN Reviewed; 354 AA.
AC P32242; A6NHA2; B3KTJ4; Q53TG6;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 191.
DE RecName: Full=Homeobox protein OTX1;
DE AltName: Full=Orthodenticle homolog 1;
GN Name=OTX1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8101484; DOI=10.1002/j.1460-2075.1993.tb05935.x;
RA Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R.,
RA Nigro V., Boncinelli E.;
RT "A vertebrate gene related to orthodenticle contains a homeodomain of the
RT bicoid class and demarcates anterior neuroectoderm in the gastrulating
RT mouse embryo.";
RL EMBO J. 12:2735-2747(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=19414065; DOI=10.1016/j.ijdevneu.2009.04.004;
RA Larsen K.B., Lutterodt M., Rath M.F., Moeller M.;
RT "Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human
RT fetal retina.";
RL Int. J. Dev. Neurosci. 27:485-492(2009).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-344, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA Vertegaal A.C.;
RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL Cell Rep. 10:1778-1791(2015).
RN [8]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-344, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Probably plays a role in the development of the brain and the
CC sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-
CC 3'.
CC -!- INTERACTION:
CC P32242; O43184-4: ADAM12; NbExp=3; IntAct=EBI-740446, EBI-12006944;
CC P32242; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-740446, EBI-10173507;
CC P32242; P05187: ALPP; NbExp=3; IntAct=EBI-740446, EBI-1211484;
CC P32242; Q9NXR5-2: ANKRD10; NbExp=3; IntAct=EBI-740446, EBI-12102070;
CC P32242; Q96PE2: ARHGEF17; NbExp=3; IntAct=EBI-740446, EBI-7543347;
CC P32242; Q03989: ARID5A; NbExp=3; IntAct=EBI-740446, EBI-948603;
CC P32242; Q674R7-2: ATG9B; NbExp=3; IntAct=EBI-740446, EBI-12837280;
CC P32242; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-740446, EBI-11519926;
CC P32242; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-740446, EBI-12809220;
CC P32242; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-740446, EBI-718615;
CC P32242; O95388: CCN4; NbExp=3; IntAct=EBI-740446, EBI-1050638;
CC P32242; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-740446, EBI-12261896;
CC P32242; O95992: CH25H; NbExp=3; IntAct=EBI-740446, EBI-12820943;
CC P32242; Q9UKJ5: CHIC2; NbExp=4; IntAct=EBI-740446, EBI-741528;
CC P32242; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-740446, EBI-947551;
CC P32242; Q6WN34-2: CHRDL2; NbExp=3; IntAct=EBI-740446, EBI-12593838;
CC P32242; P27658: COL8A1; NbExp=3; IntAct=EBI-740446, EBI-747133;
CC P32242; P49747: COMP; NbExp=7; IntAct=EBI-740446, EBI-2531022;
CC P32242; P23786: CPT2; NbExp=3; IntAct=EBI-740446, EBI-6269566;
CC P32242; O75638-2: CTAG2; NbExp=3; IntAct=EBI-740446, EBI-12265122;
CC P32242; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-740446, EBI-3867333;
CC P32242; Q9Y6K1: DNMT3A; NbExp=3; IntAct=EBI-740446, EBI-923653;
CC P32242; Q12805: EFEMP1; NbExp=3; IntAct=EBI-740446, EBI-536772;
CC P32242; O95967: EFEMP2; NbExp=3; IntAct=EBI-740446, EBI-743414;
CC P32242; Q16134: ETFDH; NbExp=3; IntAct=EBI-740446, EBI-2870454;
CC P32242; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-740446, EBI-12193763;
CC P32242; Q86X60-2: FAM72B; NbExp=3; IntAct=EBI-740446, EBI-12886238;
CC P32242; P98095: FBLN2; NbExp=3; IntAct=EBI-740446, EBI-947973;
CC P32242; Q9UBX5: FBLN5; NbExp=3; IntAct=EBI-740446, EBI-947897;
CC P32242; Q5TD97: FHL5; NbExp=3; IntAct=EBI-740446, EBI-750641;
CC P32242; P28799: GRN; NbExp=10; IntAct=EBI-740446, EBI-747754;
CC P32242; Q5TA45: INTS11; NbExp=3; IntAct=EBI-740446, EBI-748258;
CC P32242; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-740446, EBI-1055254;
CC P32242; Q96T55: KCNK16; NbExp=3; IntAct=EBI-740446, EBI-10294109;
CC P32242; Q53HC5: KLHL26; NbExp=3; IntAct=EBI-740446, EBI-724915;
CC P32242; Q5T749: KPRP; NbExp=6; IntAct=EBI-740446, EBI-10981970;
CC P32242; Q15323: KRT31; NbExp=3; IntAct=EBI-740446, EBI-948001;
CC P32242; Q92764: KRT35; NbExp=3; IntAct=EBI-740446, EBI-1058674;
CC P32242; O76014: KRT37; NbExp=3; IntAct=EBI-740446, EBI-1045716;
CC P32242; Q14533: KRT81; NbExp=8; IntAct=EBI-740446, EBI-739648;
CC P32242; P78385: KRT83; NbExp=3; IntAct=EBI-740446, EBI-10221390;
CC P32242; P78386: KRT85; NbExp=3; IntAct=EBI-740446, EBI-1049371;
CC P32242; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-740446, EBI-11959885;
CC P32242; Q8IUG1: KRTAP1-3; NbExp=7; IntAct=EBI-740446, EBI-11749135;
CC P32242; Q9BYS1: KRTAP1-5; NbExp=5; IntAct=EBI-740446, EBI-11741292;
CC P32242; P60412: KRTAP10-11; NbExp=6; IntAct=EBI-740446, EBI-10217483;
CC P32242; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-740446, EBI-10172150;
CC P32242; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-740446, EBI-10172290;
CC P32242; P60410: KRTAP10-8; NbExp=8; IntAct=EBI-740446, EBI-10171774;
CC P32242; P60411: KRTAP10-9; NbExp=9; IntAct=EBI-740446, EBI-10172052;
CC P32242; Q8IUC1: KRTAP11-1; NbExp=5; IntAct=EBI-740446, EBI-1052037;
CC P32242; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-740446, EBI-10210845;
CC P32242; P59991: KRTAP12-2; NbExp=6; IntAct=EBI-740446, EBI-10176379;
CC P32242; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-740446, EBI-11953334;
CC P32242; P60329: KRTAP12-4; NbExp=6; IntAct=EBI-740446, EBI-10176396;
CC P32242; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-740446, EBI-11953846;
CC P32242; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-740446, EBI-10241252;
CC P32242; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-740446, EBI-11992140;
CC P32242; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-740446, EBI-11988175;
CC P32242; Q3LHN2: KRTAP19-2; NbExp=5; IntAct=EBI-740446, EBI-12196745;
CC P32242; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-740446, EBI-10241353;
CC P32242; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-740446, EBI-14065470;
CC P32242; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-740446, EBI-3957672;
CC P32242; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-740446, EBI-9996449;
CC P32242; Q9BYR7: KRTAP3-2; NbExp=9; IntAct=EBI-740446, EBI-751260;
CC P32242; Q9BYR6: KRTAP3-3; NbExp=6; IntAct=EBI-740446, EBI-3957694;
CC P32242; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-740446, EBI-11957260;
CC P32242; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-740446, EBI-10302392;
CC P32242; Q9BQ66: KRTAP4-12; NbExp=7; IntAct=EBI-740446, EBI-739863;
CC P32242; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-740446, EBI-10172511;
CC P32242; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-740446, EBI-11958132;
CC P32242; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-740446, EBI-11993254;
CC P32242; Q9BYR0: KRTAP4-7; NbExp=3; IntAct=EBI-740446, EBI-10302547;
CC P32242; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-740446, EBI-11993296;
CC P32242; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-740446, EBI-11974251;
CC P32242; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-740446, EBI-11963072;
CC P32242; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-740446, EBI-10250562;
CC P32242; P26371: KRTAP5-9; NbExp=8; IntAct=EBI-740446, EBI-3958099;
CC P32242; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-740446, EBI-12111050;
CC P32242; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-740446, EBI-11962084;
CC P32242; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-740446, EBI-18394498;
CC P32242; Q9BYQ4: KRTAP9-2; NbExp=10; IntAct=EBI-740446, EBI-1044640;
CC P32242; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-740446, EBI-1043191;
CC P32242; Q9BYQ2: KRTAP9-4; NbExp=5; IntAct=EBI-740446, EBI-10185730;
CC P32242; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-740446, EBI-11958364;
CC P32242; Q14847-2: LASP1; NbExp=3; IntAct=EBI-740446, EBI-9088686;
CC P32242; Q5T7P3: LCE1B; NbExp=5; IntAct=EBI-740446, EBI-10245913;
CC P32242; Q5T751: LCE1C; NbExp=3; IntAct=EBI-740446, EBI-12224199;
CC P32242; Q5T754: LCE1F; NbExp=3; IntAct=EBI-740446, EBI-11958008;
CC P32242; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-740446, EBI-10246607;
CC P32242; O14633: LCE2B; NbExp=3; IntAct=EBI-740446, EBI-11478468;
CC P32242; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-740446, EBI-11973993;
CC P32242; Q5TA82: LCE2D; NbExp=6; IntAct=EBI-740446, EBI-10246750;
CC P32242; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-740446, EBI-10246358;
CC P32242; Q9UHV8: LGALS13; NbExp=3; IntAct=EBI-740446, EBI-3957707;
CC P32242; Q8TC57: M1AP; NbExp=3; IntAct=EBI-740446, EBI-748182;
CC P32242; Q99750: MDFI; NbExp=9; IntAct=EBI-740446, EBI-724076;
CC P32242; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-740446, EBI-2801965;
CC P32242; Q330K2-3: NDUFAF6; NbExp=3; IntAct=EBI-740446, EBI-12957691;
CC P32242; P19404: NDUFV2; NbExp=3; IntAct=EBI-740446, EBI-713665;
CC P32242; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-740446, EBI-12106440;
CC P32242; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-740446, EBI-12868744;
CC P32242; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-740446, EBI-22310682;
CC P32242; Q9P121-3: NTM; NbExp=3; IntAct=EBI-740446, EBI-12027160;
CC P32242; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-740446, EBI-10277776;
CC P32242; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-740446, EBI-12813389;
CC P32242; Q92824-2: PCSK5; NbExp=5; IntAct=EBI-740446, EBI-11956269;
CC P32242; O15496: PLA2G10; NbExp=3; IntAct=EBI-740446, EBI-726466;
CC P32242; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-740446, EBI-949255;
CC P32242; Q9NRY7: PLSCR2; NbExp=3; IntAct=EBI-740446, EBI-3937430;
CC P32242; Q16633: POU2AF1; NbExp=3; IntAct=EBI-740446, EBI-943588;
CC P32242; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-740446, EBI-740924;
CC P32242; Q93062: RBPMS; NbExp=4; IntAct=EBI-740446, EBI-740322;
CC P32242; Q9UGC6: RGS17; NbExp=6; IntAct=EBI-740446, EBI-3918154;
CC P32242; P49795: RGS19; NbExp=3; IntAct=EBI-740446, EBI-874907;
CC P32242; O76081: RGS20; NbExp=5; IntAct=EBI-740446, EBI-1052678;
CC P32242; O76081-6: RGS20; NbExp=3; IntAct=EBI-740446, EBI-10178530;
CC P32242; Q9BZR6: RTN4R; NbExp=3; IntAct=EBI-740446, EBI-5240240;
CC P32242; Q16348: SLC15A2; NbExp=3; IntAct=EBI-740446, EBI-12806032;
CC P32242; Q92922: SMARCC1; NbExp=3; IntAct=EBI-740446, EBI-355653;
CC P32242; O43609: SPRY1; NbExp=4; IntAct=EBI-740446, EBI-3866665;
CC P32242; O43597: SPRY2; NbExp=4; IntAct=EBI-740446, EBI-742487;
CC P32242; Q9C004: SPRY4; NbExp=3; IntAct=EBI-740446, EBI-354861;
CC P32242; Q5W111-2: SPRYD7; NbExp=3; IntAct=EBI-740446, EBI-12408727;
CC P32242; Q13148: TARDBP; NbExp=6; IntAct=EBI-740446, EBI-372899;
CC P32242; Q96LM6: TEX37; NbExp=3; IntAct=EBI-740446, EBI-743976;
CC P32242; Q63HR2: TNS2; NbExp=5; IntAct=EBI-740446, EBI-949753;
CC P32242; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-740446, EBI-5235829;
CC P32242; Q15654: TRIP6; NbExp=3; IntAct=EBI-740446, EBI-742327;
CC P32242; O14817: TSPAN4; NbExp=3; IntAct=EBI-740446, EBI-8652667;
CC P32242; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-740446, EBI-2514383;
CC P32242; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-740446, EBI-11975223;
CC P32242; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-740446, EBI-11957238;
CC P32242; B2RUY7: VWC2L; NbExp=5; IntAct=EBI-740446, EBI-11747707;
CC P32242; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-740446, EBI-12040603;
CC P32242; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-740446, EBI-12287587;
CC P32242; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-740446, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain. Detected in the anterior part
CC of the neural fetal retina (at protein level).
CC {ECO:0000269|PubMed:19414065}.
CC -!- DEVELOPMENTAL STAGE: Embryo.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AK095680; BAG53106.1; -; mRNA.
DR EMBL; AC009501; AAY24357.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99967.1; -; Genomic_DNA.
DR EMBL; BC007621; AAH07621.1; -; mRNA.
DR CCDS; CCDS1873.1; -.
DR PIR; S39406; S39406.
DR RefSeq; NP_001186699.1; NM_001199770.1.
DR RefSeq; NP_055377.1; NM_014562.3.
DR AlphaFoldDB; P32242; -.
DR BMRB; P32242; -.
DR SMR; P32242; -.
DR BioGRID; 111053; 147.
DR IntAct; P32242; 139.
DR MINT; P32242; -.
DR STRING; 9606.ENSP00000282549; -.
DR iPTMnet; P32242; -.
DR PhosphoSitePlus; P32242; -.
DR BioMuta; OTX1; -.
DR DMDM; 417425; -.
DR EPD; P32242; -.
DR MassIVE; P32242; -.
DR MaxQB; P32242; -.
DR PaxDb; P32242; -.
DR PeptideAtlas; P32242; -.
DR PRIDE; P32242; -.
DR ProteomicsDB; 54850; -.
DR Antibodypedia; 3233; 277 antibodies from 28 providers.
DR DNASU; 5013; -.
DR Ensembl; ENST00000282549.7; ENSP00000282549.2; ENSG00000115507.10.
DR Ensembl; ENST00000366671.7; ENSP00000355631.3; ENSG00000115507.10.
DR GeneID; 5013; -.
DR KEGG; hsa:5013; -.
DR MANE-Select; ENST00000282549.7; ENSP00000282549.2; NM_014562.4; NP_055377.1.
DR UCSC; uc002scd.4; human.
DR CTD; 5013; -.
DR DisGeNET; 5013; -.
DR GeneCards; OTX1; -.
DR HGNC; HGNC:8521; OTX1.
DR HPA; ENSG00000115507; Group enriched (salivary gland, skin).
DR MIM; 600036; gene.
DR neXtProt; NX_P32242; -.
DR OpenTargets; ENSG00000115507; -.
DR PharmGKB; PA32848; -.
DR VEuPathDB; HostDB:ENSG00000115507; -.
DR eggNOG; KOG2251; Eukaryota.
DR GeneTree; ENSGT00940000161234; -.
DR HOGENOM; CLU_064370_0_0_1; -.
DR InParanoid; P32242; -.
DR OMA; PTMDLLH; -.
DR OrthoDB; 1481439at2759; -.
DR PhylomeDB; P32242; -.
DR TreeFam; TF351179; -.
DR PathwayCommons; P32242; -.
DR SignaLink; P32242; -.
DR SIGNOR; P32242; -.
DR BioGRID-ORCS; 5013; 43 hits in 1099 CRISPR screens.
DR ChiTaRS; OTX1; human.
DR GeneWiki; OTX1; -.
DR GenomeRNAi; 5013; -.
DR Pharos; P32242; Tbio.
DR PRO; PR:P32242; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P32242; protein.
DR Bgee; ENSG00000115507; Expressed in olfactory segment of nasal mucosa and 62 other tissues.
DR ExpressionAtlas; P32242; baseline and differential.
DR Genevisible; P32242; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0048852; P:diencephalon morphogenesis; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0022037; P:metencephalon development; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003026; Otx1_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01256; OTX1HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..354
FT /note="Homeobox protein OTX1"
FT /id="PRO_0000049207"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 91..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..303
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 344
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25772364,
FT ECO:0007744|PubMed:28112733"
SQ SEQUENCE 354 AA; 37327 MW; E32C1E47464BDDAA CRC64;
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG SGTKSRPAKK KSSPVRESSG
SESSGQFTPP AVSSSASSSS SASSSSANPA AAAAAGLGGN PVAAASSLST PAASSIWSPA
SISPGSAPAS VSVPEPLAAP SNTSCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPTPSS
SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
HQGYGGSGLA FNSADCLDYK EPGAAAASSA WKLNFNSPDC LDYKDQASWR FQVL
