OTX1_MOUSE
ID OTX1_MOUSE Reviewed; 355 AA.
AC P80205;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Homeobox protein OTX1;
DE AltName: Full=Orthodenticle homolog 1;
GN Name=Otx1; Synonyms=Otx-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=8101484; DOI=10.1002/j.1460-2075.1993.tb05935.x;
RA Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R.,
RA Nigro V., Boncinelli E.;
RT "A vertebrate gene related to orthodenticle contains a homeodomain of the
RT bicoid class and demarcates anterior neuroectoderm in the gastrulating
RT mouse embryo.";
RL EMBO J. 12:2735-2747(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.
RX PubMed=1353865; DOI=10.1038/358687a0;
RA Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.;
RT "Nested expression domains of four homeobox genes in developing rostral
RT brain.";
RL Nature 358:687-690(1992).
CC -!- FUNCTION: Probably plays a role in the development of the brain and the
CC sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-
CC 3'.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain: restricted regions of the developing rostral
CC brain including the presumptive cerebral cortex and olfactory bulbs;
CC expressed in the developing olfactory, auricolar and ocular systems,
CC including the covering of the optic nerve.
CC -!- DEVELOPMENTAL STAGE: Embryo.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; BC057105; AAH57105.1; -; mRNA.
DR EMBL; BC058354; AAH58354.1; -; mRNA.
DR EMBL; X68883; CAA48754.1; -; mRNA.
DR CCDS; CCDS24468.1; -.
DR PIR; S35345; S35345.
DR RefSeq; NP_035153.1; NM_011023.3.
DR RefSeq; XP_017169827.1; XM_017314338.1.
DR AlphaFoldDB; P80205; -.
DR SMR; P80205; -.
DR BioGRID; 201992; 1.
DR STRING; 10090.ENSMUSP00000006071; -.
DR iPTMnet; P80205; -.
DR PhosphoSitePlus; P80205; -.
DR PaxDb; P80205; -.
DR PRIDE; P80205; -.
DR ProteomicsDB; 294407; -.
DR Antibodypedia; 3233; 277 antibodies from 28 providers.
DR DNASU; 18423; -.
DR Ensembl; ENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917.
DR GeneID; 18423; -.
DR KEGG; mmu:18423; -.
DR UCSC; uc007idy.1; mouse.
DR CTD; 5013; -.
DR MGI; MGI:97450; Otx1.
DR VEuPathDB; HostDB:ENSMUSG00000005917; -.
DR eggNOG; KOG2251; Eukaryota.
DR GeneTree; ENSGT00940000161234; -.
DR HOGENOM; CLU_064370_0_0_1; -.
DR InParanoid; P80205; -.
DR OMA; PTMDLLH; -.
DR OrthoDB; 1481439at2759; -.
DR PhylomeDB; P80205; -.
DR TreeFam; TF351179; -.
DR BioGRID-ORCS; 18423; 1 hit in 74 CRISPR screens.
DR PRO; PR:P80205; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P80205; protein.
DR Bgee; ENSMUSG00000005917; Expressed in nasolacrimal duct and 117 other tissues.
DR ExpressionAtlas; P80205; baseline and differential.
DR Genevisible; P80205; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0048852; P:diencephalon morphogenesis; IGI:MGI.
DR GO; GO:0030900; P:forebrain development; IGI:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0022037; P:metencephalon development; IGI:MGI.
DR GO; GO:0030901; P:midbrain development; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003026; Otx1_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01256; OTX1HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..355
FT /note="Homeobox protein OTX1"
FT /id="PRO_0000049208"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 91..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..304
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 345
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P32242"
SQ SEQUENCE 355 AA; 37532 MW; DA5136D9D4FC948F CRC64;
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG NGTKTRPVKK KSSPVRESSG
SESSGQFTPP AVSSSASSSS SASSASANPA AAAAAGLGGN PVAAASSLST PTASSIWSPA
SISPGSAPTS VSVPEPLAAP SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS
SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW RFQVL
