OTX1_RAT
ID OTX1_RAT Reviewed; 355 AA.
AC Q63410; Q64203;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Homeobox protein OTX1;
DE AltName: Full=Orthodenticle homolog 1;
GN Name=Otx1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7931541; DOI=10.1523/jneurosci.14-10-05725.1994;
RA Frantz G.D., Weimann J.M., Levin M.E., McConnell S.K.;
RT "Otx1 and Otx2 define layers and regions in developing cerebral cortex and
RT cerebellum.";
RL J. Neurosci. 14:5725-5740(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 176-323.
RX PubMed=8613727; DOI=10.1523/jneurosci.15-12-07879.1995;
RA Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F.,
RA Vaccarino F.M.;
RT "Fibroblast growth factor 2 increases Otx2 expression in precursor cells
RT from mammalian telencephalon.";
RL J. Neurosci. 15:7879-7891(1995).
CC -!- FUNCTION: Probably plays a role in the development of the brain and the
CC sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-
CC 3' (By similarity). May play a role in the specification or
CC differentiation of neurons in the deep layers of the cerebral cortex,
CC and also in cerebellar regionalization during early development.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain: restricted regions of the developing rostral
CC brain including the presumptive cerebral cortex and olfactory bulbs;
CC expressed in the developing olfactory, auricolar and ocular systems,
CC including the covering of the optic nerve.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the forebrain and midbrain
CC during development, and in addition is also seen in discrete spatial
CC and temporal domains in the developing cerebral cortex and cerebellum.
CC Confined to a subpopulation of neurons in layers 5 and 6 within the
CC adult cerebral cortex and during development expression is high in the
CC progenitors of these deep-layer cells. Expressed in the developing
CC cerebellum in spatially restricted regions of the external granular
CC layer.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L32602; AAA53557.1; -; mRNA.
DR EMBL; S81924; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; I56547; I56547.
DR RefSeq; NP_037241.1; NM_013109.2.
DR AlphaFoldDB; Q63410; -.
DR SMR; Q63410; -.
DR PaxDb; Q63410; -.
DR GeneID; 25646; -.
DR KEGG; rno:25646; -.
DR UCSC; RGD:3237; rat.
DR CTD; 5013; -.
DR RGD; 3237; Otx1.
DR InParanoid; Q63410; -.
DR OrthoDB; 1481439at2759; -.
DR PhylomeDB; Q63410; -.
DR PRO; PR:Q63410; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0048852; P:diencephalon morphogenesis; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0022037; P:metencephalon development; ISO:RGD.
DR GO; GO:0030901; P:midbrain development; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003026; Otx1_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01256; OTX1HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..355
FT /note="Homeobox protein OTX1"
FT /id="PRO_0000049209"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 92..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..304
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 345
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P32242"
FT CONFLICT 219
FT /note="T -> A (in Ref. 2; S81924)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="R -> G (in Ref. 2; S81924)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 355 AA; 37603 MW; C875871723D0B876 CRC64;
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG NGTKSRPVKK KSSPVRESSG
SESSGQFTPP AVSSSASSSS SASSASANPA AAAAAGLGGN PVAAASSLST PTASSIWSPA
SISPGSAPAS VSVPEPLGAP SNASCMQRSV AAGAATAATS YPMSYGQGRS YGQGYPAPSS
SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW RFQVL
