ID   OTX2B_XENLA             Reviewed;         289 AA.
AC   Q6DKN2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Homeobox protein OTX2-B;
DE            Short=xOTX2-B;
DE   AltName: Full=Orthodenticle 2-B;
DE   AltName: Full=Orthodenticle-A-like protein B;
GN   Name=otx2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=7743941; DOI=10.1242/dev.121.4.993;
RA   Blitz I.L., Cho K.W.;
RT   "Anterior neurectoderm is progressively induced during gastrulation: the
RT   role of the Xenopus homeobox gene orthodenticle.";
RL   Development 121:993-1004(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a central role in the initial events of axis
CC       formation and in particular in specifying anterior head regions and
CC       their spatial relationship with trunk structures. Activates the head
CC       organizer gene cer1 by acting synergistically with siamois and mix-
CC       A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also
CC       binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to
CC       stimulate expression (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:7743941}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U19813; AAB63527.1; -; mRNA.
DR   EMBL; BC070526; AAH70526.1; -; mRNA.
DR   RefSeq; NP_001084955.1; NM_001091486.1.
DR   AlphaFoldDB; Q6DKN2; -.
DR   SMR; Q6DKN2; -.
DR   DNASU; 432013; -.
DR   GeneID; 432013; -.
DR   KEGG; xla:432013; -.
DR   CTD; 432013; -.
DR   Xenbase; XB-GENE-485224; otx2.L.
DR   OMA; KSPHYAM; -.
DR   OrthoDB; 1481439at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 432013; Expressed in gastrula and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003022; Otx2_TF.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01257; OTX2HOMEOBOX.
DR   PRINTS; PR01255; OTXHOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Homeobox protein OTX2-B"
FT                   /id="PRO_0000259762"
FT   DNA_BIND        38..97
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          93..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            87
FT                   /note="Determines DNA-binding specificity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   289 AA;  31689 MW;  8ACE280DCC8BF441 CRC64;
     MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DILEALFAKT
     RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP SKKKTSPARE
     VSSESGTSGQ FSPPCSTSGP VISSSTAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT
     QASGYSQGYA SSTSYFGGMD CGSYLTPMHH QLSGPGATLS PMSTNAVTSH LNQSQAALSS
     QAYGASSLGF NSTADCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL