ID   OTX2_DANRE              Reviewed;         289 AA.
AC   Q91981;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Homeobox protein OTX2;
DE            Short=zOTX2;
DE   AltName: Full=Orthodenticle homolog 2;
GN   Name=otx2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AB;
RX   PubMed=7898305; DOI=10.1016/0169-328x(94)90004-3;
RA   Mori H., Miyazaki Y., Morita T., Nitta H., Mishina M.;
RT   "Different spatio-temporal expressions of three otx homeoprotein
RT   transcripts during zebrafish embryogenesis.";
RL   Brain Res. Mol. Brain Res. 27:221-231(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7893604; DOI=10.1016/0925-4773(94)90062-0;
RA   Li Y., Allende M.L., Finkelstein R., Weinberg E.S.;
RT   "Expression of two zebrafish orthodenticle-related genes in the embryonic
RT   brain.";
RL   Mech. Dev. 48:229-244(1994).
CC   -!- FUNCTION: May play a role in very early embryogenesis, gastrulation,
CC       and the development and subdivision of the diencephalon and the
CC       midbrain.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Appears at 9 hours of development, and at 12 hours
CC       of development significant levels are found in the developing brain
CC       posterior to ocular vesicles. Distributed mainly in the midbrain, part
CC       of the diencephalon beneath the epiphysis and in the epiphysis at 18
CC       hours of development. Found in the ventral part of the midbrain and in
CC       the dorsal part of the diencephalon at 24 hours of development.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; D26173; BAA05159.1; -; mRNA.
DR   EMBL; U14592; AAA78901.1; -; mRNA.
DR   PIR; I51752; I51752.
DR   RefSeq; NP_571326.1; NM_131251.1.
DR   RefSeq; XP_005158940.1; XM_005158883.3.
DR   RefSeq; XP_009291522.1; XM_009293247.2.
DR   AlphaFoldDB; Q91981; -.
DR   SMR; Q91981; -.
DR   BioGRID; 78681; 1.
DR   STRING; 7955.ENSDARP00000111153; -.
DR   PaxDb; Q91981; -.
DR   Ensembl; ENSDART00000008816; ENSDARP00000020202; ENSDARG00000011235.
DR   Ensembl; ENSDART00000126097; ENSDARP00000111153; ENSDARG00000011235.
DR   GeneID; 30501; -.
DR   KEGG; dre:30501; -.
DR   CTD; 30501; -.
DR   ZFIN; ZDB-GENE-980526-406; otx2b.
DR   eggNOG; KOG2251; Eukaryota.
DR   GeneTree; ENSGT00940000155014; -.
DR   HOGENOM; CLU_064370_0_0_1; -.
DR   InParanoid; Q91981; -.
DR   OMA; KSPHYAM; -.
DR   OrthoDB; 1481439at2759; -.
DR   PhylomeDB; Q91981; -.
DR   TreeFam; TF351179; -.
DR   PRO; PR:Q91981; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000011235; Expressed in camera-type eye and 56 other tissues.
DR   ExpressionAtlas; Q91981; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0097306; P:cellular response to alcohol; IDA:ZFIN.
DR   GO; GO:0021549; P:cerebellum development; IGI:ZFIN.
DR   GO; GO:0030902; P:hindbrain development; IGI:ZFIN.
DR   GO; GO:0030901; P:midbrain development; IGI:ZFIN.
DR   GO; GO:0030917; P:midbrain-hindbrain boundary development; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0003406; P:retinal pigment epithelium development; IGI:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003022; Otx2_TF.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01257; OTX2HOMEOBOX.
DR   PRINTS; PR01255; OTXHOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Homeobox protein OTX2"
FT                   /id="PRO_0000049214"
FT   DNA_BIND        38..97
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          93..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  31594 MW;  13D60DFC7A0FD16E CRC64;
     MMSYLKQPPY TVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT
     RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKSSPARE
     ASSESGASGQ FTPPSSTSVP AISTTTAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT
     QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLTGPGSTLS PMSSNAVTSH LNQSPASLPT
     QGYGASGLGF NSTADCLDYK DQASSWKLNF NADCLDYKDQ TSSWKFQVL