OTX2_RAT
ID OTX2_RAT Reviewed; 70 AA.
AC Q64201;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Homeobox protein OTX2;
DE AltName: Full=Orthodenticle homolog 2;
DE Flags: Fragment;
GN Name=Otx2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND INDUCTION BY FGF2.
RX PubMed=8613727; DOI=10.1523/jneurosci.15-12-07879.1995;
RA Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F.,
RA Vaccarino F.M.;
RT "Fibroblast growth factor 2 increases Otx2 expression in precursor cells
RT from mammalian telencephalon.";
RL J. Neurosci. 15:7879-7891(1995).
CC -!- FUNCTION: Transcription factor probably involved in the development of
CC the brain and the sense organs. Can bind to the bicoid/BCD target
CC sequence (BTS): 5'-TCTAATCCC-3'. {ECO:0000250|UniProtKB:P32243}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32243}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the dorsal and basal telencephalon,
CC in a subpopulation of proliferating neuroblasts, early in development
CC (at least from 11.5 dpc). {ECO:0000269|PubMed:8613727}.
CC -!- INDUCTION: Up-regulated by FGF2 tretament in embryonic telencephalon
CC primary cultures. {ECO:0000269|PubMed:8613727}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; S81922; AAP32271.1; -; mRNA.
DR AlphaFoldDB; Q64201; -.
DR STRING; 10116.ENSRNOP00000018109; -.
DR PaxDb; Q64201; -.
DR UCSC; RGD:1305705; rat.
DR RGD; 1305705; Otx2.
DR eggNOG; KOG2251; Eukaryota.
DR InParanoid; Q64201; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0030426; C:growth cone; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0048856; P:anatomical structure development; ISO:RGD.
DR GO; GO:0009887; P:animal organ morphogenesis; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0045165; P:cell fate commitment; ISO:RGD.
DR GO; GO:0001708; P:cell fate specification; ISO:RGD.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; ISO:RGD.
DR GO; GO:0007417; P:central nervous system development; ISO:RGD.
DR GO; GO:0048852; P:diencephalon morphogenesis; ISO:RGD.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; ISO:RGD.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD.
DR GO; GO:0007492; P:endoderm development; ISO:RGD.
DR GO; GO:0042706; P:eye photoreceptor cell fate commitment; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0048382; P:mesendoderm development; ISO:RGD.
DR GO; GO:0022037; P:metencephalon development; ISO:RGD.
DR GO; GO:0030901; P:midbrain development; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
DR GO; GO:0048664; P:neuron fate determination; ISO:RGD.
DR GO; GO:0048709; P:oligodendrocyte differentiation; ISO:RGD.
DR GO; GO:0040019; P:positive regulation of embryonic development; ISO:RGD.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0090009; P:primitive streak formation; ISO:RGD.
DR GO; GO:0065003; P:protein-containing complex assembly; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; ISO:RGD.
DR GO; GO:0021978; P:telencephalon regionalization; ISO:RGD.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF03529; TF_Otx; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN <1..>70
FT /note="Homeobox protein OTX2"
FT /id="PRO_0000049212"
FT REGION 34..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 70
SQ SEQUENCE 70 AA; 7139 MW; 4CE56B48E00E4120 CRC64;
MTYTQASGYS QGYAGSTSYF GGMDCGSYLT PMHHQLPGPG ATLSPMGTNA VTSHLNQSPA
SLSTQGYGAS
