ID   OTX2_XENTR              Reviewed;         289 AA.
AC   Q28FN6; A4II69;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Homeobox protein OTX2;
DE   AltName: Full=Orthodenticle 2;
GN   Name=otx2; ORFNames=TGas114a06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a central role in the initial events of axis
CC       formation and in particular in specifying anterior head regions and
CC       their spatial relationship with trunk structures. Activates the head
CC       organizer gene cer1 by acting synergistically with siamois and mix-
CC       A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also
CC       binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to
CC       stimulate expression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR761863; CAJ82551.1; -; mRNA.
DR   EMBL; BC135884; AAI35885.1; -; mRNA.
DR   RefSeq; NP_001016177.1; NM_001016177.2.
DR   AlphaFoldDB; Q28FN6; -.
DR   BMRB; Q28FN6; -.
DR   SMR; Q28FN6; -.
DR   PaxDb; Q28FN6; -.
DR   DNASU; 548931; -.
DR   Ensembl; ENSXETT00000034219; ENSXETP00000034219; ENSXETG00000015687.
DR   GeneID; 548931; -.
DR   KEGG; xtr:548931; -.
DR   CTD; 5015; -.
DR   Xenbase; XB-GENE-485220; otx2.
DR   eggNOG; KOG2251; Eukaryota.
DR   HOGENOM; CLU_064370_0_0_1; -.
DR   InParanoid; Q28FN6; -.
DR   OMA; PHPKGPW; -.
DR   OrthoDB; 1481439at2759; -.
DR   TreeFam; TF351179; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015687; Expressed in gastrula and 25 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0097306; P:cellular response to alcohol; IEA:Ensembl.
DR   GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR   GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR   GO; GO:0030917; P:midbrain-hindbrain boundary development; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0003406; P:retinal pigment epithelium development; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003022; Otx2_TF.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01257; OTX2HOMEOBOX.
DR   PRINTS; PR01255; OTXHOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Homeobox protein OTX2"
FT                   /id="PRO_0000259763"
FT   DNA_BIND        38..97
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          93..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            87
FT                   /note="Determines DNA-binding specificity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   289 AA;  31596 MW;  C2D0F8D6C9FF0C54 CRC64;
     MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT
     RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP SKKKPSPARE
     VSSESGTSGQ FSPPCSTSVP VISSSTAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT
     QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLSGAGATLS PMGTNAVTSH LNQSPAALSS
     QAYGASSLGF NSTADCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL