ID   OTX5A_XENLA             Reviewed;         290 AA.
AC   Q9PVM0; Q5XH79;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Homeobox protein otx5-A;
DE   AltName: Full=Orthodenticle homolog 5-A;
DE   AltName: Full=Xotx5;
GN   Name=otx5-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:BAA86260.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Cement gland {ECO:0000312|EMBL:BAA86260.1};
RX   PubMed=10830431; DOI=10.1046/j.1440-169x.2000.00491.x;
RA   Kuroda H., Hayata T., Eisaki A., Asashima M.;
RT   "Cloning a novel developmental regulating gene, Xotx5: its potential role
RT   in anterior formation in Xenopus laevis.";
RL   Dev. Growth Differ. 42:87-93(2000).
RN   [2] {ECO:0000312|EMBL:AAH84194.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAH84194.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in anterior and eye
CC       development. Promotes the differentiation of both rod and cone
CC       photoreceptors cells in the retina. Together with other retinal
CC       homeobox proteins, acts as an effector of a cellular clock which,
CC       depending on cell cycle progression, establishes the generation of
CC       distinct retinal neuronal cell types. Acts synergistically with nrl to
CC       activate the rhodopsin promoter (By similarity). Promotes the formation
CC       of anterior regions and represses the formation of posterior structures
CC       during development. {ECO:0000250|UniProtKB:Q9PT61,
CC       ECO:0000269|PubMed:10830431}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9PT61,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Initially expressed in the Spemann organizer region
CC       of early gastrula embryos. Expression then becomes localized to the
CC       anterior region; confined to the cement gland anlage at stages 19-25
CC       and localized to the forebrain, optic vesicle and otocyst at stage 28.
CC       {ECO:0000269|PubMed:10830431}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at low level from stage 1 to stage 9,
CC       when expression levels increase. {ECO:0000269|PubMed:10830431}.
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DR   EMBL; AB034702; BAA86260.1; -; mRNA.
DR   EMBL; BC084194; AAH84194.1; -; mRNA.
DR   RefSeq; NP_001079119.1; NM_001085650.1.
DR   AlphaFoldDB; Q9PVM0; -.
DR   SMR; Q9PVM0; -.
DR   DNASU; 373653; -.
DR   GeneID; 373653; -.
DR   KEGG; xla:373653; -.
DR   CTD; 373653; -.
DR   Xenbase; XB-GENE-6252876; crx.S.
DR   OMA; RSAGYPM; -.
DR   OrthoDB; 1481439at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 373653; Expressed in camera-type eye and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IMP:UniProtKB.
DR   GO; GO:0042706; P:eye photoreceptor cell fate commitment; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01255; OTXHOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..290
FT                   /note="Homeobox protein otx5-A"
FT                   /id="PRO_0000283765"
FT   DNA_BIND        38..97
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          93..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        85
FT                   /note="W -> C (in Ref. 2; AAH84194)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   290 AA;  31552 MW;  D9FAEDBA929FA925 CRC64;
     MMSYIKQPHY AVNGLTLAGT GMDLLHSAVG YPTTPRKQRR ERTTFTRAQL DILESLFAKT
     RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQS TGQAKPRPAK KKTSPARETN
     SEASTNGQYS PPPPGTAVTP SSTAGATVSI WSPASISPIP DPLSIATTPC MQRSAGYPMT
     YSQAPAYTQS YGGSSSYFTG LDCGSYLSPM HPQLSAPGST LSPIASSTMG SHLSQSPASL
     SAQGYGASSL GFTSVDCLDY KDQTASWKLN FNATDCLDYK DQSSWKFQVL