OTX5B_XENLA
ID OTX5B_XENLA Reviewed; 290 AA.
AC Q9PT61;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Homeobox protein otx5-B;
DE AltName: Full=Orthodenticle homolog 5-B;
DE AltName: Full=XOtx5b;
GN Name=otx5-b; Synonyms=otx5b {ECO:0000312|EMBL:CAB63872.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAB63872.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Head {ECO:0000312|EMBL:CAB63872.1};
RX PubMed=10940620; DOI=10.1016/s0925-4773(00)00367-1;
RA Vignali R., Colombetti S., Lupo G., Zhang W., Stachel S., Harland R.M.,
RA Barsacchi G.;
RT "Xotx5b, a new member of the Otx gene family, may be involved in anterior
RT and eye development in Xenopus laevis.";
RL Mech. Dev. 96:3-13(2000).
RN [2] {ECO:0000312|EMBL:AAH77545.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAH77545.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12588845; DOI=10.1242/dev.00343;
RA Viczian A.S., Vignali R., Zuber M.E., Barsacchi G., Harris W.A.;
RT "XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus
RT retina.";
RL Development 130:1281-1294(2003).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=15347652; DOI=10.1074/jbc.m406080200;
RA Whitaker S.L., Knox B.E.;
RT "Conserved transcriptional activators of the Xenopus rhodopsin gene.";
RL J. Biol. Chem. 279:49010-49018(2004).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=16040025; DOI=10.1016/j.ydbio.2005.05.041;
RA Wang J.C.-C., Harris W.A.;
RT "The role of combinational coding by homeodomain and bHLH transcription
RT factors in retinal cell fate specification.";
RL Dev. Biol. 285:101-115(2005).
RN [6] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16903786; DOI=10.1371/journal.pbio.0040272;
RA Decembrini S., Andreazzoli M., Vignali R., Barsacchi G., Cremisi F.;
RT "Timing the generation of distinct retinal cells by homeobox proteins.";
RL PLoS Biol. 4:1562-1571(2006).
CC -!- FUNCTION: Transcription factor involved in anterior and eye
CC development. Promotes the differentiation of both rod and cone
CC photoreceptors cells in the retina. Together with other retinal
CC homeobox proteins, acts as an effector of a cellular clock which,
CC depending on cell cycle progression, establishes the generation of
CC distinct retinal neuronal cell types. Acts synergistically with nrl to
CC activate the rhodopsin promoter. Promotes the formation of anterior
CC regions and represses the formation of posterior structures during
CC development. {ECO:0000269|PubMed:10940620, ECO:0000269|PubMed:12588845,
CC ECO:0000269|PubMed:15347652, ECO:0000269|PubMed:16040025,
CC ECO:0000269|PubMed:16903786}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:16903786}.
CC -!- TISSUE SPECIFICITY: Initially expressed in the Spemann organizer of
CC early gastrula embryos. Expression in the organizer begins to decrease
CC during late gastrulation and has disappeared by stage 11.5. Expression
CC then persists and intensifies in the anterior neuroectoderm. Exhibits a
CC dynamic expression pattern during neurulation and by neural tube
CC closure (stage 20), expression is restricted to the cement gland anlage
CC and epiphysis (pineal gland) anlagen. During tailbud stages, expression
CC in the cement gland decreases and from stage 24, expression appears in
CC the neural retina. By stage 37, expression becomes restricted to the
CC outer and inner nuclear layers of the retina and the ciliary marginal
CC zone (CMZ; the source of retinal growth). In mature embryonic retinas
CC (stage 42), expressed preferentially in photoreceptors and in a subset
CC of bipolar cells. Translation occurs during late retinogenesis and
CC requires cell cycle progression with the timing of translation
CC paralleling that of the generation of photoreceptor cells. In the CMZ,
CC translation begins in early post-mitotic cells.
CC {ECO:0000269|PubMed:10940620, ECO:0000269|PubMed:12588845,
CC ECO:0000269|PubMed:16903786}.
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DR EMBL; AJ251846; CAB63872.1; -; mRNA.
DR EMBL; BC077545; AAH77545.1; -; mRNA.
DR RefSeq; NP_001081916.1; NM_001088447.1.
DR RefSeq; XP_018084196.1; XM_018228707.1.
DR AlphaFoldDB; Q9PT61; -.
DR SMR; Q9PT61; -.
DR DNASU; 398118; -.
DR GeneID; 398118; -.
DR KEGG; xla:398118; -.
DR CTD; 398118; -.
DR Xenbase; XB-GENE-865179; crx.L.
DR OMA; AVGYQNT; -.
DR OrthoDB; 1481439at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:UniProtKB.
DR GO; GO:0042706; P:eye photoreceptor cell fate commitment; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..290
FT /note="Homeobox protein otx5-B"
FT /id="PRO_0000283766"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 93..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 290 AA; 31603 MW; 2277651FCCA03E7C CRC64;
MMSYIKQPHY AVNGLTLAGT GMDLLHSAVG YPTNPRKQRR ERTTFTRAQL DILESLFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQS TGQAKPRPAK KKTSPARETN
SEASTNGQYS PPPPGTAVTP SSSASATVSI WSPASISPIP DPLSAVTNPC MQRSTGYPMT
YSQAPAYTQS YGGSSSYFTG LDCGSYLSPM HPQLSAPGAT LSPIATPTMG SHLSQSPASL
SAQGYGAASL GFTSVDCLDY KDQTASWKLN FNATDCLDYK DQSSWKFQVL
