ID   OTX5_XENTR              Reviewed;         290 AA.
AC   Q28EM7;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Homeobox protein otx5;
DE   AltName: Full=Orthodenticle homolog 5;
GN   Name=otx5 {ECO:0000250|UniProtKB:Q9PVM0}; ORFNames=TGas127o03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83418.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83418.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in anterior and eye
CC       development. Promotes the differentiation of both rod and cone
CC       photoreceptors cells in the retina. Together with other retinal
CC       homeobox proteins, acts as an effector of a cellular clock which,
CC       depending on cell cycle progression, establishes the generation of
CC       distinct retinal neuronal cell types. Acts synergistically with nrl to
CC       activate the rhodopsin promoter. Promotes the formation of anterior
CC       regions and represses the formation of posterior structures during
CC       development (By similarity). {ECO:0000250|UniProtKB:Q9PT61}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9PT61,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; CR848167; CAJ83418.1; -; mRNA.
DR   RefSeq; NP_001016021.1; NM_001016021.2.
DR   RefSeq; XP_012823813.1; XM_012968359.1.
DR   AlphaFoldDB; Q28EM7; -.
DR   BMRB; Q28EM7; -.
DR   SMR; Q28EM7; -.
DR   STRING; 8364.ENSXETP00000040682; -.
DR   PaxDb; Q28EM7; -.
DR   GeneID; 548775; -.
DR   KEGG; xtr:548775; -.
DR   CTD; 1406; -.
DR   Xenbase; XB-GENE-478452; crx.
DR   eggNOG; KOG2251; Eukaryota.
DR   InParanoid; Q28EM7; -.
DR   OrthoDB; 1481439at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018775; Expressed in gastrula and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR   GO; GO:0042706; P:eye photoreceptor cell fate commitment; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01255; OTXHOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..290
FT                   /note="Homeobox protein otx5"
FT                   /id="PRO_0000283767"
FT   DNA_BIND        38..97
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          93..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   290 AA;  31532 MW;  02BF722677303E85 CRC64;
     MMSYIKQPHY AVNGLTLAGT GMDLLHSAVG YPTTPRKQRR ERTTFTRAQL DILEALFAKT
     RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQS TGQAKPRPAK KKTSPARETN
     SEASTNGQYS PPPPGTAVTP SSTASATVSI WSPASISPIP DPLSAATTPC MQRSAGYPMT
     YSQAPAYTQS YGGSSSYFTG LDCGSYLSPM HPQLSAPGAT LSPIATPTMG SHLSQSPASL
     SAQGYGASSL GFTSVDCLDY KDQTASWKLN FNATDCLDYK DQSSWKFQVL