ID   OTX_STRPU               Reviewed;         371 AA.
AC   Q26417;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Homeobox protein OTX;
DE            Short=SpOTX;
DE   AltName: Full=Orthodenticle homolog;
GN   Name=OTX;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7875376; DOI=10.1006/dbio.1995.1046;
RA   Gan L., Mao C.-A., Wikramanayake A., Angerer L.M., Angerer R.C.,
RA   Klein W.H.;
RT   "An orthodenticle-related protein from Strongylocentrotus purpuratus.";
RL   Dev. Biol. 167:517-528(1995).
CC   -!- FUNCTION: May play a role in activation of the SPEC2A gene, binds to
CC       the TAATCC motif with high specificity. May have additional functions
CC       in the developing embryos.
CC   -!- SUBUNIT: Binds DNA as a monomer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Found initially in all cells of the cleaving
CC       embryo, but gradually becomes restricted to oral ectoderm and endoderm
CC       cells.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; S76899; AAB33568.1; -; mRNA.
DR   AlphaFoldDB; Q26417; -.
DR   SMR; Q26417; -.
DR   STRING; 7668.SPU_010424.a-tr; -.
DR   eggNOG; KOG2251; Eukaryota.
DR   HOGENOM; CLU_941923_0_0_1; -.
DR   InParanoid; Q26417; -.
DR   PhylomeDB; Q26417; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..371
FT                   /note="Homeobox protein OTX"
FT                   /id="PRO_0000049216"
FT   DNA_BIND        131..190
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  41215 MW;  B6BD493D684A33F7 CRC64;
     MEALSDLACR EIKMESHSPQ DSKDLNVKPV KLERLGMSSS PPRLTIDCGD TGRSPVPSHM
     EPPGGARVPY PMHLYPYPYA YSNPMYGEGA LPAPDRHLPP TQQHPMFQPQ VLGPMTSERP
     HSNGIDPPRK QRRERTTFTR AQLDVLETLF SRTRYPDIFM REEVAMKINL PESRVQVWFK
     NRRAKCRQQQ QQQQNGPNSN NTTNKPRPAK KKTPPPTPRE NDAPTTTSSD TPPFKASPSV
     SSSMPNNNSI WSPASIAPQP MSSDHLAANM SNNSCMQHSY TMPNAQPAAG YTAQGYQSPY
     FGAGLDYLSH MPQFPGSINH QMAASAMNNG PMTTMASQLP PPHHAHMPMG AMSSAECIDG
     KEQPQWKFQS L