ID   OVALX_CHICK             Reviewed;         232 AA.
AC   P01013;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Ovalbumin-related protein X;
DE   AltName: Full=Gene X protein;
DE   Flags: Fragment;
GN   Name=SERPINB14C; Synonyms=X;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7418002; DOI=10.1016/0092-8674(80)90309-8;
RA   Heilig R., Perrin F., Gannon F., Mandel J.-L., Chambon P.;
RT   "The ovalbumin gene family: structure of the X gene and evolution of
RT   duplicated split genes.";
RL   Cell 20:625-637(1980).
RN   [2]
RP   PROTEIN SEQUENCE OF 30-48; 73-100; 124-132; 197-207 AND 216-229, TISSUE
RP   SPECIFICITY, INDUCTION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Egg white {ECO:0000303|PubMed:25436390};
RX   PubMed=25436390; DOI=10.1021/jf504469t;
RA   Kim J., Choi Y.H.;
RT   "Differential abundance of egg white proteins in laying hens treated with
RT   corticosterone.";
RL   J. Agric. Food Chem. 62:12346-12359(2014).
CC   -!- TISSUE SPECIFICITY: Expressed in egg white (at protein level).
CC       {ECO:0000269|PubMed:25436390}.
CC   -!- INDUCTION: Up-regulated by dietary stress. Significantly increased
CC       expression between days 0 to 5 in egg whites of eggs laid by
CC       corticosterone-fed hens (at protein level).
CC       {ECO:0000269|PubMed:25436390}.
CC   -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; V00385; CAA23683.1; -; Genomic_DNA.
DR   EMBL; V00386; CAA23684.1; -; Genomic_DNA.
DR   EMBL; V00387; CAA23685.1; -; Genomic_DNA.
DR   PIR; A01243; DXCH.
DR   AlphaFoldDB; P01013; -.
DR   SMR; P01013; -.
DR   MEROPS; I04.958; -.
DR   PaxDb; P01013; -.
DR   VEuPathDB; HostDB:geneid_420898; -.
DR   InParanoid; P01013; -.
DR   PhylomeDB; P01013; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; IDA:AgBase.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:AgBase.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0051412; P:response to corticosterone; IDA:AgBase.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome.
FT   CHAIN           <1..232
FT                   /note="Ovalbumin-related protein X"
FT                   /id="PRO_0000094130"
FT   NON_TER         1
SQ   SEQUENCE   232 AA;  26291 MW;  6B5B86EC4D3B9195 CRC64;
     QIKDLLVSSS TDLDTTLVLV NAIYFKGMWK TAFNAEDTRE MPFHVTKQES KPVQMMCMNN
     SFNVATLPAE KMKILELPFA SGDLSMLVLL PDEVSDLERI EKTINFEKLT EWTNPNTMEK
     RRVKVYLPQM KIEEKYNLTS VLMALGMTDL FIPSANLTGI SSAESLKISQ AVHGAFMELS
     EDGIEMAGST GVIEDIKHSP ESEQFRADHP FLFLIKHNPT NTIVYFGRYW SP