OVCA2_HUMAN
ID OVCA2_HUMAN Reviewed; 227 AA.
AC Q8WZ82; Q86XN3; Q8IW87; Q9UCX9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Esterase OVCA2;
DE EC=3.1.2.- {ECO:0000305};
DE AltName: Full=Ovarian cancer-associated gene 2 protein;
GN Name=OVCA2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Ovary;
RX PubMed=8616839;
RA Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J.,
RA Godwin A.K.;
RT "Identification of two candidate tumor suppressor genes on chromosome
RT 17p13.3.";
RL Cancer Res. 56:1997-2002(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND PROTEOLYTIC
RP DEGRADATION.
RX PubMed=11979432; DOI=10.1002/ijc.10334;
RA Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X.,
RA Godwin A.K.;
RT "OVCA2 is downregulated and degraded during retinoid-induced apoptosis.";
RL Int. J. Cancer 99:185-192(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Godwin A.K., Vanderveer L.A., Schultz D.C.;
RT "OVCA locus.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Duodenum, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:11979432, ECO:0000269|PubMed:8616839}.
CC -!- PTM: Proteolytically degraded in response to RA and 4HPR treatment in a
CC time- and dose-dependent manner in the promyelocytic leukemia cell line
CC HL-60.
CC -!- SIMILARITY: Belongs to the LovG family. {ECO:0000305}.
CC -!- CAUTION: Encoded in an intron of the gene DPH1/OVCA1 (same strand).
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF073528; AAC62628.1; -; mRNA.
DR EMBL; AF321875; AAL35713.1; -; mRNA.
DR EMBL; AF335321; AAN04659.1; -; Genomic_DNA.
DR EMBL; BC040696; AAH40696.1; -; mRNA.
DR EMBL; BC041170; AAH41170.1; -; mRNA.
DR CCDS; CCDS11015.1; -.
DR RefSeq; NP_543012.1; NM_080822.2.
DR AlphaFoldDB; Q8WZ82; -.
DR SMR; Q8WZ82; -.
DR BioGRID; 125881; 6.
DR IntAct; Q8WZ82; 2.
DR STRING; 9606.ENSP00000461388; -.
DR ESTHER; human-OVCA2; FSH1.
DR iPTMnet; Q8WZ82; -.
DR PhosphoSitePlus; Q8WZ82; -.
DR BioMuta; OVCA2; -.
DR DMDM; 74731010; -.
DR EPD; Q8WZ82; -.
DR jPOST; Q8WZ82; -.
DR MassIVE; Q8WZ82; -.
DR MaxQB; Q8WZ82; -.
DR PaxDb; Q8WZ82; -.
DR PeptideAtlas; Q8WZ82; -.
DR PRIDE; Q8WZ82; -.
DR ProteomicsDB; 75237; -.
DR Antibodypedia; 69773; 61 antibodies from 15 providers.
DR DNASU; 124641; -.
DR Ensembl; ENST00000572195.3; ENSP00000461388.1; ENSG00000262664.3.
DR GeneID; 124641; -.
DR KEGG; hsa:124641; -.
DR MANE-Select; ENST00000572195.3; ENSP00000461388.1; NM_080822.3; NP_543012.1.
DR UCSC; uc002ftx.4; human.
DR CTD; 124641; -.
DR DisGeNET; 124641; -.
DR GeneCards; OVCA2; -.
DR HGNC; HGNC:24203; OVCA2.
DR HPA; ENSG00000262664; Low tissue specificity.
DR MalaCards; OVCA2; -.
DR MIM; 607896; gene.
DR neXtProt; NX_Q8WZ82; -.
DR OpenTargets; ENSG00000262664; -.
DR PharmGKB; PA165432281; -.
DR VEuPathDB; HostDB:ENSG00000262664; -.
DR eggNOG; KOG2551; Eukaryota.
DR GeneTree; ENSGT00390000003541; -.
DR HOGENOM; CLU_051938_2_3_1; -.
DR InParanoid; Q8WZ82; -.
DR OMA; EEPTVCR; -.
DR OrthoDB; 1190789at2759; -.
DR PhylomeDB; Q8WZ82; -.
DR TreeFam; TF313006; -.
DR PathwayCommons; Q8WZ82; -.
DR SignaLink; Q8WZ82; -.
DR BioGRID-ORCS; 124641; 45 hits in 1075 CRISPR screens.
DR GenomeRNAi; 124641; -.
DR Pharos; Q8WZ82; Tbio.
DR PRO; PR:Q8WZ82; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8WZ82; protein.
DR Bgee; ENSG00000262664; Expressed in mucosa of transverse colon and 93 other tissues.
DR Genevisible; Q8WZ82; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR GO; GO:0032526; P:response to retinoic acid; IDA:UniProtKB.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005645; FSH_dom.
DR Pfam; PF03959; FSH1; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..227
FT /note="Esterase OVCA2"
FT /id="PRO_0000300876"
FT REGION 44..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 119
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P38777"
FT ACT_SITE 179
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P38777"
FT ACT_SITE 206
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P38777"
FT CONFLICT 84
FT /note="S -> C (in Ref. 4; AAH40696)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="G -> S (in Ref. 1; AAC62628)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 227 AA; 24418 MW; E4A4694A7E30FBD8 CRC64;
MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD
FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ
GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK
VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE
