ASD4_NEUCR
ID ASD4_NEUCR Reviewed; 426 AA.
AC Q9HEV5; Q7S997; V5IMY2;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=GATA type zinc finger protein asd-4;
DE AltName: Full=Ascus development protein 4;
GN Name=asd-4; ORFNames=NCU15829, NCU20921;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX PubMed=10998244; DOI=10.1021/bi000886j;
RA Feng B., Haas H., Marzluf G.A.;
RT "ASD4, a new GATA factor of Neurospora crassa, displays sequence-specific
RT DNA binding and functions in ascus and ascospore development.";
RL Biochemistry 39:11065-11073(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Transcriptional regulator that functions in sexual
CC development; disruption of asd-4 gene results in agenesis of ascus and
CC ascospore with macroscopically normal fruiting body formation. The
CC GATA-type zinc finger domain binds to DNA sequences from its own
CC promoter region.
CC -!- SUBUNIT: Homotetramer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESA43052.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF319953; AAG45180.1; -; Genomic_DNA.
DR EMBL; CM002239; ESA43052.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_011394349.1; XM_011396047.1.
DR AlphaFoldDB; Q9HEV5; -.
DR SMR; Q9HEV5; -.
DR STRING; 5141.EFNCRP00000007048; -.
DR EnsemblFungi; ESA43052; ESA43052; NCU15829.
DR GeneID; 23569377; -.
DR KEGG; ncr:NCU15829; -.
DR HOGENOM; CLU_035349_0_0_1; -.
DR InParanoid; Q9HEV5; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..426
FT /note="GATA type zinc finger protein asd-4"
FT /id="PRO_0000083473"
FT ZN_FING 16..40
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 70..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 182..292
FT /evidence="ECO:0000255"
FT COMPBIAS 75..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 46533 MW; 4B7DE193050E280E CRC64;
MATMANHDRE TTQPTCQNCA TSTTPLWRRD EMGQVLCNAC GLFLKLHGRP RPISLKTDVI
KSRNRVKTMR PDLAKQKKQQ QQQQQQQNLA ATADMNGGVG MMDPNNPAAA ARRASQKSIN
GHPVDDNSPV SRTGTPNVYN PHIPIDHSLE YQFQAQQIPG FGVPTASPGR APSPMNGEHM
PQTHEQLLAA NASLKTRVSE LEVIQELYRG RLHQLETEEN IRQASEPGKL EAQLRAQIDA
MGEAHQQLQK ELEESHRREN MLKRRLDELE VELKDVKDAL ESQDNGRHKK IRLDENVKTE
PYAEVVEPQQ PEQQQPAPAE QPIPTPMAID EATPAPAPAP EAAPEQAPAP APEPVQEQAQ
EPEPAPVSEP TEASAPAPAP EADSVVPEPT PAAPESAPTE EPAAPETEAS EPPTTAPVEE
APKAES
