OVCA2_MOUSE
ID OVCA2_MOUSE Reviewed; 225 AA.
AC Q9D7E3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Esterase OVCA2;
DE EC=3.1.2.- {ECO:0000305};
DE AltName: Full=Ovarian cancer-associated gene 2 protein homolog;
GN Name=Ovca2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=129/SvEv;
RX PubMed=11527402; DOI=10.1006/bbrc.2001.5488;
RA Chen C.-M., Behringer R.R.;
RT "Cloning, structure, and expression of the mouse Ovca1 gene.";
RL Biochem. Biophys. Res. Commun. 286:1019-1026(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, Intestine, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Strongly expressed in kidney and liver. Moderately
CC expressed in brain, skin and testis. Weakly expressed in heart, lung,
CC small intestine, spleen, stomach and thymus.
CC {ECO:0000269|PubMed:11527402}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryonic stem (ES) cells.
CC {ECO:0000269|PubMed:11527402}.
CC -!- SIMILARITY: Belongs to the LovG family. {ECO:0000305}.
CC -!- CAUTION: Encoded in an intron of the gene DPH1/OVCA1 (same strand).
CC {ECO:0000305}.
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DR EMBL; AY078171; AAM14630.1; -; mRNA.
DR EMBL; AK009308; BAB26208.1; -; mRNA.
DR EMBL; AK030338; BAC26910.1; -; mRNA.
DR EMBL; AK033511; BAC28331.1; -; mRNA.
DR EMBL; AL603905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25041.1; -.
DR RefSeq; NP_081412.1; NM_027136.3.
DR AlphaFoldDB; Q9D7E3; -.
DR SMR; Q9D7E3; -.
DR STRING; 10090.ENSMUSP00000071493; -.
DR ESTHER; mouse-OVCA2; FSH1.
DR PhosphoSitePlus; Q9D7E3; -.
DR EPD; Q9D7E3; -.
DR MaxQB; Q9D7E3; -.
DR PaxDb; Q9D7E3; -.
DR PeptideAtlas; Q9D7E3; -.
DR PRIDE; Q9D7E3; -.
DR ProteomicsDB; 294408; -.
DR Antibodypedia; 69773; 61 antibodies from 15 providers.
DR DNASU; 246257; -.
DR Ensembl; ENSMUST00000071562; ENSMUSP00000071493; ENSMUSG00000038268.
DR GeneID; 246257; -.
DR KEGG; mmu:246257; -.
DR UCSC; uc007kdf.1; mouse.
DR CTD; 124641; -.
DR MGI; MGI:2179725; Ovca2.
DR VEuPathDB; HostDB:ENSMUSG00000038268; -.
DR eggNOG; KOG2551; Eukaryota.
DR GeneTree; ENSGT00390000003541; -.
DR HOGENOM; CLU_051938_2_3_1; -.
DR InParanoid; Q9D7E3; -.
DR OMA; EEPTVCR; -.
DR PhylomeDB; Q9D7E3; -.
DR TreeFam; TF313006; -.
DR BioGRID-ORCS; 246257; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ovca2; mouse.
DR PRO; PR:Q9D7E3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D7E3; protein.
DR Bgee; ENSMUSG00000038268; Expressed in epiblast (generic) and 61 other tissues.
DR Genevisible; Q9D7E3; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR GO; GO:0032526; P:response to retinoic acid; ISO:MGI.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005645; FSH_dom.
DR Pfam; PF03959; FSH1; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..225
FT /note="Esterase OVCA2"
FT /id="PRO_0000300877"
FT ACT_SITE 119
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P38777"
FT ACT_SITE 177
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P38777"
FT ACT_SITE 204
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P38777"
SQ SEQUENCE 225 AA; 24246 MW; 82A418D1C180F8B9 CRC64;
MAARQTLRVL CLAGFRQSER GFREKTGALR KTLRGRAELV CLSGPHPVPE AAAPEGSCPD
SGPCSPEEQP RGWWFSEEEA DVFSALEEST VCRGLQEALE TVARALDTLG PFDGLLGFSQ
GAALAAYVCA LGQAGDPRFP LPRFIILVSG FCPRGLKEPI LQSPMSLPSL HVFGDTDRVI
PSQESMQLAS RFLGAVTLTH SGGHFIPAAA SQRQAYLKFL DQFAE
