ID   OVOL1_BOVIN             Reviewed;         267 AA.
AC   A2VDT4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Putative transcription factor Ovo-like 1;
GN   Name=OVOL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative transcription factor. Involved in hair formation and
CC       spermatogenesis. May function in the differentiation and/or maintenance
CC       of the urogenital system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC133390; AAI33391.1; -; mRNA.
DR   RefSeq; NP_001074990.1; NM_001081521.1.
DR   AlphaFoldDB; A2VDT4; -.
DR   SMR; A2VDT4; -.
DR   STRING; 9913.ENSBTAP00000016791; -.
DR   PaxDb; A2VDT4; -.
DR   PRIDE; A2VDT4; -.
DR   Ensembl; ENSBTAT00000016791; ENSBTAP00000016791; ENSBTAG00000012656.
DR   GeneID; 513727; -.
DR   KEGG; bta:513727; -.
DR   CTD; 5017; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012656; -.
DR   VGNC; VGNC:32505; OVOL1.
DR   eggNOG; KOG3576; Eukaryota.
DR   GeneTree; ENSGT00940000161363; -.
DR   HOGENOM; CLU_087964_0_0_1; -.
DR   InParanoid; A2VDT4; -.
DR   OMA; HKAFTYQ; -.
DR   OrthoDB; 1419156at2759; -.
DR   TreeFam; TF337552; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000012656; Expressed in surface of tongue and 75 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009913; P:epidermal cell differentiation; IBA:GO_Central.
DR   GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR   GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0044771; P:meiotic cell cycle phase transition; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:1901994; P:negative regulation of meiotic cell cycle phase transition; IEA:Ensembl.
DR   GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR   InterPro; IPR027756; Ovo-like.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR10032; PTHR10032; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..267
FT                   /note="Putative transcription factor Ovo-like 1"
FT                   /id="PRO_0000284951"
FT   ZN_FING         118..140
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         146..168
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         174..197
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         213..235
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   267 AA;  30165 MW;  1E0AC8D88533A2A8 CRC64;
     MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYQEPEPS VAEPPSCPLA
     LDMSLRNSSY SVTPGPCVVA QLPSEDMSRL AGPQSRDHGF LRTKMKVTLG DGPSGDLFTC
     HICQKAFTYQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD
     KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP
     LLRKTSKKVA VALQNTVTSL LQGAHHV