OVOL1_HUMAN
ID OVOL1_HUMAN Reviewed; 267 AA.
AC O14753; Q6PCB1;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Putative transcription factor Ovo-like 1;
DE Short=hOvo1;
GN Name=OVOL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 87-267.
RX PubMed=9383297; DOI=10.1007/s003359900620;
RA Chidambaram A., Allikmets R., Chandrasekarappa S., Guru S.C., Modi W.,
RA Gerrard B., Dean M.;
RT "Characterization of a human homolog (OVOL1) of the Drosophila ovo gene,
RT which maps to chromosome 11q13.";
RL Mamm. Genome 8:950-951(1997).
CC -!- FUNCTION: Putative transcription factor. Involved in hair formation and
CC spermatogenesis. May function in the differentiation and/or maintenance
CC of the urogenital system (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O14753; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-3917713, EBI-6658203;
CC O14753; Q03252: LMNB2; NbExp=3; IntAct=EBI-3917713, EBI-2830427;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in fetal kidney, and also in adult
CC pancreas and placenta. Not expressed in intestine, peripheral blood
CC lymphocytes and ovary.
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DR EMBL; BX648725; CAH56127.1; -; mRNA.
DR EMBL; BC059408; AAH59408.1; -; mRNA.
DR EMBL; AF016045; AAB72084.1; -; mRNA.
DR CCDS; CCDS8112.1; -.
DR RefSeq; NP_004552.2; NM_004561.3.
DR AlphaFoldDB; O14753; -.
DR SMR; O14753; -.
DR BioGRID; 111057; 11.
DR IntAct; O14753; 4.
DR STRING; 9606.ENSP00000337862; -.
DR iPTMnet; O14753; -.
DR PhosphoSitePlus; O14753; -.
DR BioMuta; OVOL1; -.
DR jPOST; O14753; -.
DR MassIVE; O14753; -.
DR MaxQB; O14753; -.
DR PaxDb; O14753; -.
DR PeptideAtlas; O14753; -.
DR PRIDE; O14753; -.
DR ProteomicsDB; 48206; -.
DR Antibodypedia; 1312; 244 antibodies from 28 providers.
DR DNASU; 5017; -.
DR Ensembl; ENST00000335987.8; ENSP00000337862.3; ENSG00000172818.10.
DR GeneID; 5017; -.
DR KEGG; hsa:5017; -.
DR MANE-Select; ENST00000335987.8; ENSP00000337862.3; NM_004561.4; NP_004552.2.
DR UCSC; uc001ofp.4; human.
DR CTD; 5017; -.
DR DisGeNET; 5017; -.
DR GeneCards; OVOL1; -.
DR HGNC; HGNC:8525; OVOL1.
DR HPA; ENSG00000172818; Tissue enhanced (esophagus, skin, testis).
DR MIM; 602313; gene.
DR neXtProt; NX_O14753; -.
DR OpenTargets; ENSG00000172818; -.
DR PharmGKB; PA32853; -.
DR VEuPathDB; HostDB:ENSG00000172818; -.
DR eggNOG; KOG3576; Eukaryota.
DR GeneTree; ENSGT00940000161363; -.
DR HOGENOM; CLU_087964_0_0_1; -.
DR InParanoid; O14753; -.
DR OMA; HKAFTYQ; -.
DR OrthoDB; 1419156at2759; -.
DR PhylomeDB; O14753; -.
DR TreeFam; TF337552; -.
DR PathwayCommons; O14753; -.
DR SignaLink; O14753; -.
DR BioGRID-ORCS; 5017; 9 hits in 1096 CRISPR screens.
DR GenomeRNAi; 5017; -.
DR Pharos; O14753; Tbio.
DR PRO; PR:O14753; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O14753; protein.
DR Bgee; ENSG00000172818; Expressed in gingival epithelium and 127 other tissues.
DR ExpressionAtlas; O14753; baseline and differential.
DR Genevisible; O14753; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009913; P:epidermal cell differentiation; IBA:GO_Central.
DR GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0044771; P:meiotic cell cycle phase transition; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:1901994; P:negative regulation of meiotic cell cycle phase transition; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR InterPro; IPR027756; Ovo-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10032; PTHR10032; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..267
FT /note="Putative transcription factor Ovo-like 1"
FT /id="PRO_0000047011"
FT ZN_FING 118..140
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 146..168
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 174..197
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..235
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 150
FT /note="Y -> G (in Ref. 3; AAB72084)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 30259 MW; 57C67CD8A060A9B8 CRC64;
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS VAEPPSCPLA
LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF LRTKMKVTLG DSPSGDLFTC
RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD
KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP
LLRKTSKKVA VALQNTVTSL LQGSPHL
