OVOL1_MOUSE
ID OVOL1_MOUSE Reviewed; 267 AA.
AC Q9WTJ2; Q545S2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Putative transcription factor Ovo-like 1;
DE Short=mOvo1;
DE Short=mOvo1a;
GN Name=Ovol1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RA Schonbaum C.P., Fantes J., Mahowald A.P.;
RT "Characterization of mouse and Caenorhabditis elegans genes related to the
RT Drosophila melanogaster ovo/svb gene.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=9808631; DOI=10.1101/gad.12.21.3452;
RA Dai X., Schonbaum C., Degenstein L., Bai W., Mahowald A., Fuchs E.;
RT "The ovo gene required for cuticle formation and oogenesis in flies is
RT involved in hair formation and spermatogenesis in mice.";
RL Genes Dev. 12:3452-3463(1998).
CC -!- FUNCTION: Putative transcription factor. Involved in hair formation and
CC spermatogenesis. May function in the differentiation and/or maintenance
CC of the urogenital system. {ECO:0000269|PubMed:9808631}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in skin, testis, kidney and weakly in
CC lung. Not detected in heart, brain, spleen, liver and skeletal muscle.
CC -!- DEVELOPMENTAL STAGE: First expressed at 14.5 dpc in the suprabasal
CC layers of developing epidermis, at 15.5 dpc expression begins in the
CC inner cells of developing hair germs and restricted to inner root
CC sheath and/or precortical cells of developing hair follicles.
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DR EMBL; AF134804; AAD29689.1; -; mRNA.
DR EMBL; AF134805; AAD29690.1; -; mRNA.
DR EMBL; AK003801; BAB23003.1; -; mRNA.
DR EMBL; AK028577; BAC26015.1; -; mRNA.
DR EMBL; AK132478; BAE21188.1; -; mRNA.
DR EMBL; AK132505; BAE21208.1; -; mRNA.
DR EMBL; AK132506; BAE21209.1; -; mRNA.
DR EMBL; BC021411; AAH21411.1; -; mRNA.
DR CCDS; CCDS29469.1; -.
DR RefSeq; NP_064319.1; NM_019935.3.
DR AlphaFoldDB; Q9WTJ2; -.
DR SMR; Q9WTJ2; -.
DR STRING; 10090.ENSMUSP00000025861; -.
DR iPTMnet; Q9WTJ2; -.
DR PhosphoSitePlus; Q9WTJ2; -.
DR PaxDb; Q9WTJ2; -.
DR PRIDE; Q9WTJ2; -.
DR ProteomicsDB; 295491; -.
DR Antibodypedia; 1312; 244 antibodies from 28 providers.
DR DNASU; 18426; -.
DR Ensembl; ENSMUST00000025861; ENSMUSP00000025861; ENSMUSG00000024922.
DR GeneID; 18426; -.
DR KEGG; mmu:18426; -.
DR UCSC; uc008gdu.1; mouse.
DR CTD; 5017; -.
DR MGI; MGI:1330290; Ovol1.
DR VEuPathDB; HostDB:ENSMUSG00000024922; -.
DR eggNOG; KOG3576; Eukaryota.
DR GeneTree; ENSGT00940000161363; -.
DR HOGENOM; CLU_087964_0_0_1; -.
DR InParanoid; Q9WTJ2; -.
DR OMA; HKAFTYQ; -.
DR OrthoDB; 1419156at2759; -.
DR PhylomeDB; Q9WTJ2; -.
DR TreeFam; TF337552; -.
DR BioGRID-ORCS; 18426; 4 hits in 75 CRISPR screens.
DR PRO; PR:Q9WTJ2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9WTJ2; protein.
DR Bgee; ENSMUSG00000024922; Expressed in lip and 93 other tissues.
DR ExpressionAtlas; Q9WTJ2; baseline and differential.
DR Genevisible; Q9WTJ2; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009913; P:epidermal cell differentiation; IBA:GO_Central.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IMP:MGI.
DR GO; GO:0043616; P:keratinocyte proliferation; IGI:MGI.
DR GO; GO:0001822; P:kidney development; IMP:MGI.
DR GO; GO:0044771; P:meiotic cell cycle phase transition; IMP:MGI.
DR GO; GO:0007498; P:mesoderm development; IMP:MGI.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IGI:MGI.
DR GO; GO:1901994; P:negative regulation of meiotic cell cycle phase transition; IMP:MGI.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IGI:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IGI:MGI.
DR InterPro; IPR027756; Ovo-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10032; PTHR10032; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..267
FT /note="Putative transcription factor Ovo-like 1"
FT /id="PRO_0000047012"
FT ZN_FING 118..140
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 146..168
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 174..197
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..236
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 267 AA; 30222 MW; DAD4F51150C21C2D CRC64;
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEAS VAEPPSCPLA
LDMSLRDSSY SVAPGPCVVA QLPSEDVSHL TDPQSRDQGF LRTKMKVTLG DSPNGDLFTC
HICQKSFTHQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD
KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKERHPDSP
LLRKTSKKVA VALQNTVTSL LQGSPHL
