OVOL3_HUMAN
ID OVOL3_HUMAN Reviewed; 214 AA.
AC O00110;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Putative transcription factor ovo-like protein 3;
GN Name=OVOL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May act as a transcription regulator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB51180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AD001527; AAB51180.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; O00110; -.
DR SMR; O00110; -.
DR STRING; 9606.ENSP00000465620; -.
DR iPTMnet; O00110; -.
DR PhosphoSitePlus; O00110; -.
DR BioMuta; OVOL3; -.
DR MassIVE; O00110; -.
DR PRIDE; O00110; -.
DR Ensembl; ENST00000585332.3; ENSP00000465620.2; ENSG00000105261.8.
DR UCSC; uc031rkj.2; human.
DR GeneCards; OVOL3; -.
DR HGNC; HGNC:14186; OVOL3.
DR HPA; ENSG00000105261; Tissue enhanced (brain, testis).
DR MIM; 616442; gene.
DR neXtProt; NX_O00110; -.
DR VEuPathDB; HostDB:ENSG00000105261; -.
DR eggNOG; KOG3576; Eukaryota.
DR GeneTree; ENSGT00940000162348; -.
DR InParanoid; O00110; -.
DR ChiTaRS; OVOL3; human.
DR Pharos; O00110; Tdark.
DR PRO; PR:O00110; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O00110; protein.
DR Bgee; ENSG00000105261; Expressed in right testis and 86 other tissues.
DR ExpressionAtlas; O00110; baseline and differential.
DR Genevisible; O00110; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009913; P:epidermal cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR027756; Ovo-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10032; PTHR10032; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..214
FT /note="Putative transcription factor ovo-like protein 3"
FT /id="PRO_0000320622"
FT ZN_FING 94..116
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 122..144
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 150..173
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 214 AA; 23826 MW; A23D553861191AF4 CRC64;
MPRAFLVRSR RPQPPNWGHL PDQLRGDAYI PGGPLTVPGG KGQERRSVTI WLFSSDCSSL
GGPPAQQSSS VRDPWTAQPT QGNLTSAPRG PGTLGCPLCP KAFPLQRMLT RHLKCHSPVR
RHLCRCCGKG FHDAFDLKRH MRTHTGIRPF RCSACGKAFT QRCSLEAHLA KVHGQPASYA
YRERREKLHV CEDCGFTSSR PDTYAQHRAL HRAA
