OVOLH_CAEEL
ID OVOLH_CAEEL Reviewed; 280 AA.
AC G5EDU6;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Transcription factor ovo-like homolog lin-48 {ECO:0000305};
DE AltName: Full=Abnormal cell lineage protein 48 {ECO:0000312|WormBase:F34D10.5};
GN Name=lin-48 {ECO:0000312|WormBase:F34D10.5};
GN ORFNames=F34D10.5 {ECO:0000312|WormBase:F34D10.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAD29691.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Schonbaum C.P., Fantes J., Mahowald A.P.;
RT "Characterization of mouse and Caenorhabditis elegans genes related to the
RT Drosophila melanogaster ovo/svb gene.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF HIS-179 AND PRO-188.
RX PubMed=10511553; DOI=10.1093/genetics/153.2.731;
RA Chamberlin H.M., Brown K.B., Sternberg P.W., Thomas J.H.;
RT "Characterization of seven genes affecting Caenorhabditis elegans hindgut
RT development.";
RL Genetics 153:731-742(1999).
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP ASP-175; HIS-179 AND PRO-188.
RX PubMed=11532910; DOI=10.1242/dev.128.15.2857;
RA Johnson A.D., Fitzsimmons D., Hagman J., Chamberlin H.M.;
RT "EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis
RT elegans organ development.";
RL Development 128:2857-2865(2001).
RN [5] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF HIS-179.
RX PubMed=12231624; DOI=10.1101/gad.996302;
RA Wang X., Chamberlin H.M.;
RT "Multiple regulatory changes contribute to the evolution of the
RT Caenorhabditis lin-48 ovo gene.";
RL Genes Dev. 16:2345-2349(2002).
RN [6] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF HIS-179.
RX PubMed=14758362; DOI=10.1038/ng1301;
RA Wang X., Chamberlin H.M.;
RT "Evolutionary innovation of the excretory system in Caenorhabditis
RT elegans.";
RL Nat. Genet. 36:231-232(2004).
RN [7] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=16310763; DOI=10.1016/j.ydbio.2005.10.029;
RA Wang X., Jia H., Chamberlin H.M.;
RT "The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a
RT cell-specific target gene in C. elegans.";
RL Dev. Biol. 289:456-465(2006).
CC -!- FUNCTION: Transcription factor (By similarity). Involved in development
CC of the hindgut, the male tail, and the excretory duct cell
CC (PubMed:10511553, PubMed:11532910, PubMed:12231624). Involved in
CC modulating function of excretory duct cells (PubMed:14758362). Plays a
CC role in left/right patterning of cell fates in the hindgut
CC (PubMed:10511553, PubMed:11532910). {ECO:0000250|UniProtKB:Q9BRP0,
CC ECO:0000269|PubMed:10511553, ECO:0000269|PubMed:11532910,
CC ECO:0000269|PubMed:12231624, ECO:0000269|PubMed:14758362}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11532910}.
CC -!- DEVELOPMENTAL STAGE: Expressed in late embryogenesis and into adulthood
CC (PubMed:11532910, PubMed:16310763). Expression in the excretory duct
CC cell begins in the majority of embryos by comma stage and persists
CC throughout larval development into adulthood (PubMed:16310763).
CC Expressed in L1 stage larvae in the excretory duct cell, neuronal
CC support cells of the phasmid and labial sensory structures and a small
CC number of additional unidentified cells in the head (PubMed:11532910,
CC PubMed:12231624). {ECO:0000269|PubMed:11532910,
CC ECO:0000269|PubMed:12231624, ECO:0000269|PubMed:16310763}.
CC -!- MISCELLANEOUS: Differences in the regulation of lin-48 expression may
CC explain, at least in part, differences in excretory duct morphology and
CC function between C.elegans and the related species C.briggsae.
CC {ECO:0000269|PubMed:12231624, ECO:0000269|PubMed:14758362}.
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DR EMBL; AF134806; AAD29691.1; -; mRNA.
DR EMBL; BX284603; CAA84317.2; -; Genomic_DNA.
DR PIR; T21721; T21721.
DR RefSeq; NP_497759.1; NM_065358.3.
DR SMR; G5EDU6; -.
DR IntAct; G5EDU6; 17.
DR STRING; 6239.F34D10.5; -.
DR EnsemblMetazoa; F34D10.5.1; F34D10.5.1; WBGene00003033.
DR GeneID; 175485; -.
DR KEGG; cel:CELE_F34D10.5; -.
DR CTD; 175485; -.
DR WormBase; F34D10.5; CE24940; WBGene00003033; lin-48.
DR eggNOG; KOG3576; Eukaryota.
DR GeneTree; ENSGT00940000165739; -.
DR HOGENOM; CLU_079474_0_0_1; -.
DR OMA; THQYAYK; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003033; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009913; P:epidermal cell differentiation; IBA:GO_Central.
DR GO; GO:0007442; P:hindgut morphogenesis; IMP:WormBase.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:WormBase.
DR InterPro; IPR027756; Ovo-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10032; PTHR10032; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..280
FT /note="Transcription factor ovo-like homolog lin-48"
FT /id="PRO_0000456205"
FT ZN_FING 133..155
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 161..183
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..212
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MUTAGEN 175
FT /note="D->Y: In sy548; defects in hindgut development.
FT Defects in the development of U, F and K' hindgut cells."
FT /evidence="ECO:0000269|PubMed:11532910"
FT MUTAGEN 179
FT /note="H->R: In sa469; defects in hindgut development.
FT Produces ectopic spicule cells. Defects in the development
FT of U, F and K' hindgut cells. Morphological defects in
FT excretory duct cells. Increases sensitivity to salt (NaCl)
FT in the environment, reducing viability."
FT /evidence="ECO:0000269|PubMed:10511553,
FT ECO:0000269|PubMed:11532910, ECO:0000269|PubMed:12231624,
FT ECO:0000269|PubMed:14758362"
FT MUTAGEN 188
FT /note="P->S: In sy234; defects in hindgut development.
FT Abnormal F, B and U cell lineages in male tail. Produces
FT ectopic spicule cells. Defects in the development of U, F
FT and K' hindgut cells."
FT /evidence="ECO:0000269|PubMed:10511553,
FT ECO:0000269|PubMed:11532910"
SQ SEQUENCE 280 AA; 31603 MW; 72D3266F1753909B CRC64;
MDSRVWLPLI GAHLLPRDIS VITQMIANNN NTSISRSSTN SSKPEEKNSK KFLIERFLDD
DPSPPASILS PSPKAAIPSP IINPAVEFVN GGYGVKNPLA PLISSFETTS IPCSTVSPSS
LISSSKDEFQ DSLTCHICGK KFGLQRLLNR HIKCHSDLKR YLCTFCGKGF NDTFDLKRHT
RTHTGVRPYK CEQCEKSFTQ RCSLESHLRK VHGVTHQYAY KERRSKVFVC EDCGYTDEKF
EVYLSHIKVV HPFSAAYLRF TQLQKKNSSM KPEQLSKISL
