OX1R_BOVIN
ID OX1R_BOVIN Reviewed; 425 AA.
AC Q0GBZ5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Orexin/Hypocretin receptor type 1 {ECO:0000250|UniProtKB:O43613};
GN Name=HCRTR1 {ECO:0000250|UniProtKB:O43613};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhang L., Chen H., Zhang A.L., Zhang C.L., Zhang L.Z., Zhu Z.Y.;
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Moderately selective excitatory receptor for orexin-A and,
CC with a lower affinity, for orexin-B neuropeptide. Triggers an increase
CC in cytoplasmic Ca(2+) levels in response to orexin-A binding.
CC {ECO:0000250|UniProtKB:O43613}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43613};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O43613}.
CC -!- DOMAIN: The N-terminal region is required for orexin signaling.
CC {ECO:0000250|UniProtKB:O43613}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ874350; ABI34075.1; -; mRNA.
DR RefSeq; NP_001041647.1; NM_001048182.1.
DR AlphaFoldDB; Q0GBZ5; -.
DR SMR; Q0GBZ5; -.
DR STRING; 9913.ENSBTAP00000013687; -.
DR PaxDb; Q0GBZ5; -.
DR PRIDE; Q0GBZ5; -.
DR Ensembl; ENSBTAT00000076106; ENSBTAP00000062326; ENSBTAG00000010366.
DR GeneID; 282248; -.
DR KEGG; bta:282248; -.
DR CTD; 3061; -.
DR VEuPathDB; HostDB:ENSBTAG00000010366; -.
DR VGNC; VGNC:29781; HCRTR1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230390; -.
DR HOGENOM; CLU_009579_6_3_1; -.
DR InParanoid; Q0GBZ5; -.
DR OMA; VMECRSV; -.
DR OrthoDB; 981089at2759; -.
DR TreeFam; TF315303; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000010366; Expressed in bone marrow and 86 other tissues.
DR ExpressionAtlas; Q0GBZ5; baseline.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0016499; F:orexin receptor activity; ISS:UniProtKB.
DR GO; GO:0007631; P:feeding behavior; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000204; Orexin_rcpt.
DR InterPro; IPR004059; OX1R.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01521; OREXIN1R.
DR PRINTS; PR01064; OREXINR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..425
FT /note="Orexin/Hypocretin receptor type 1"
FT /id="PRO_0000269712"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 68..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 83..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 106..119
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 141..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 161..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 183..213
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 214..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 236..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 299..321
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 322..336
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 337..360
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 361..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 26..41
FT /note="Required for response to orexin-A"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT SITE 36
FT /note="Important for responses to orexin"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 119..202
FT /evidence="ECO:0000250|UniProtKB:O43613"
SQ SEQUENCE 425 AA; 47756 MW; 3DDAEF93FF95C9B6 CRC64;
MEPSATPGPQ MGVPTEGRER SPEPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFFVA
LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK
VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAVMVPQA
AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR
KLWGRQIPGT TSALVRNWKR PSVQLEEQGQ GLGAEPQPRA RAFLAEVKQM RARRKTAKML
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF
LSGKFREQFK AAFSCCLPGL GPCVSLKVPS PRSSASHKSL SLQSRCSVSK ASEHVLLTSV
TTVLP
