OX1R_PIG
ID OX1R_PIG Reviewed; 425 AA.
AC O97661; Q2MK77;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Orexin/Hypocretin receptor type 1 {ECO:0000250|UniProtKB:O43613};
DE AltName: Full=Orexin receptor type 1 {ECO:0000305|Ref.1};
DE Short=Ox-1-R;
DE Short=Ox1-R;
DE Short=Ox1R;
GN Name=HCRTR1 {ECO:0000250|UniProtKB:O43613};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1] {ECO:0000312|EMBL:ABC59143.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus {ECO:0000312|EMBL:ABC59143.1};
RA Bin Y.F.;
RT "Molecular cloning of the porcine type 1 orexin receptor.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 135-220.
RC TISSUE=Hypothalamus;
RA Matteri R.L., Dyer C.J.;
RT "Partial cDNA sequence of the porcine type 1 orexin receptor.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Moderately selective excitatory receptor for orexin-A and,
CC with a lower affinity, for orexin-B neuropeptide. Triggers an increase
CC in cytoplasmic Ca(2+) levels in response to orexin-A binding.
CC {ECO:0000250|UniProtKB:O43613}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43613};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O43613}.
CC -!- DOMAIN: The N-terminal region is required for orexin signaling.
CC {ECO:0000250|UniProtKB:O43613}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; DQ321701; ABC59143.1; -; mRNA.
DR EMBL; AF097995; AAC68703.1; -; mRNA.
DR RefSeq; NP_001036811.1; NM_001043346.1.
DR AlphaFoldDB; O97661; -.
DR SMR; O97661; -.
DR STRING; 9823.ENSSSCP00000003905; -.
DR PaxDb; O97661; -.
DR GeneID; 387287; -.
DR KEGG; ssc:387287; -.
DR CTD; 3061; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; O97661; -.
DR OrthoDB; 981089at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0016499; F:orexin receptor activity; ISS:UniProtKB.
DR GO; GO:0007631; P:feeding behavior; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000204; Orexin_rcpt.
DR InterPro; IPR004059; OX1R.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01521; OREXIN1R.
DR PRINTS; PR01064; OREXINR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..425
FT /note="Orexin/Hypocretin receptor type 1"
FT /id="PRO_0000069986"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 68..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 83..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 106..119
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 141..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 161..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 183..213
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 214..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 236..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 299..321
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 322..336
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TRANSMEM 337..360
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT TOPO_DOM 361..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT REGION 26..41
FT /note="Required for response to orexin-A"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT SITE 36
FT /note="Important for responses to orexin"
FT /evidence="ECO:0000250|UniProtKB:O43613"
FT DISULFID 119..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 425 AA; 47438 MW; 921FE8C11F1EA641 CRC64;
MEPSATPGPQ MGVPTGVGDP SLVPPDYEEE FLSYLWRDYL YPKQYEWVLI AAYVAVFLVA
LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK
VIPYLQAVSV SVAVLTLSFI ALDRWYAIYH PLLFKSTARR ARGSILGIWA VSPAVMVPQA
AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR
KLWGRQIPGT TSALVRNWKR PSDQLEDQGQ GPGAEPPPRA RAFLAEVKQM RARRKTAKML
MVVLLVFALC YLPISVLNVL KRVFGMFRQT SDREAVYACF TFSHWLVYAN SAANPIIYNF
LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL SLQSRCSVSK ISEHVVLTSV
TTVLP
